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Last Updated: September 30, 2020

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Patent: 10,167,486

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Summary for Patent: 10,167,486
Title:Vectors and methods for long-term immune evasion to prolong transplant viability
Abstract: A kit for altering allogeneic human cells for a human recipient where the kit includes a set of lentivirus vectors where each of the lentivirus vectors expresses a sequence targeting a consensus conserved nucleic acid sequence, which when expressed in cells, functions as a negative modulator for nucleic acid encoding a domain having a mismatch in an HLA protein and where the set of lentivirus vectors includes individual lentivirus vectors that correspond to individual HLA mismatches for a set of HLA mismatches that consist of HLA Class I mismatches and at least one HLA Class II mismatch and where the kit is for treatment of human cells by an appropriate subset of the set of lentivirus vectors based at least in part on a determined subset of the set of HLA mismatches between a human donor and a human recipient or between human cells and a human recipient.
Inventor(s): Cicciarelli; James C. (Rolling Hills, CA), Kasahara; Noriyuki (Los Angeles, CA), Logg; Christopher R. (South Pasedena, CA)
Application Number:15/621,880
Patent Claims:see list of patent claims

Details for Patent 10,167,486

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial NATIONAL INSTITUTE OF TRANSPLANTATION FOUNDATION (Los Angeles, CA) 2024-05-18 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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