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Last Updated: September 28, 2020

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Patent: 10,159,746

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Summary for Patent: 10,159,746
Title:Cyclodextrin complexation methods for formulating peptide proteasome inhibitors
Abstract: This disclosure provides methods for formulating compositions comprising one or more peptide proteasome inhibitors and a cyclodextrin, particularly a substituted cyclodextrin. As well as cyclodextrin complexation methods of formulating a peptide proteasome inhibitor (e.g., a compound of formula (1)-(5) or a pharmaceutically acceptable salt thereof) with one or more cyclodextrins. Such methods substantially increase the solubility and stability of these proteasome inhibitors and facilitate both their manufacture and administration. For example, homogenous solutions of a compound of formula (5) (carfilzomib) can be obtained at a pharmaceutically useful pH (e.g., about 3.5) and at higher concentrations (e.g., about 5 mg/mL) than could be obtained without one or more cyclodextrins and the processes of complexation between the compound and one or more cyclodextrins provided herein. ##STR00001##
Inventor(s): Lewis; Evan (Pacifica, CA), Shwonek; Peter (San Francisco, CA), Dalziel; Sean (San Francisco, CA), Jumaa; Mouhannad (Foster City, CA)
Assignee: Onyx Therapeutics, Inc. (Thousand Oaks, CA)
Application Number:14/399,582
Patent Claims:see list of patent claims

Details for Patent 10,159,746

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 001 2006-05-25   Start Trial Onyx Therapeutics, Inc. (Thousand Oaks, CA) 2032-05-08 search
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 1 2006-05-25   Start Trial Onyx Therapeutics, Inc. (Thousand Oaks, CA) 2032-05-08 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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