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Last Updated: December 14, 2019

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Patent: 10,138,260

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Summary for Patent: 10,138,260
Title:Compounds of phosphinanes and azaphosphinanes, a process for their preparation and pharmaceutical compositions containing them
Abstract: Compounds of formula (I) ##STR00001## wherein: Ak.sub.1 represents an alkyl chain, X represents --(CH.sub.2).sub.m--, --CH(R)--, --N(R)--, --CH.sub.2--N(R)--, --N(R)--CH.sub.2-- or --CH.sub.2--N(R)--CH.sub.2--, m and R are as defined in the description, R.sub.1 and R.sub.2 each represent H when X represents --(CH.sub.2).sub.m--, --CH(R)--, --N(R)--, --CH.sub.2--N(R)-- or --N(R)--CH.sub.2--, or together form a bond when X represents --CH.sub.2--N(R)--CH.sub.2--, R.sub.3 represents NH.sub.2, Cy-NH.sub.2, Cy-Ak.sub.3-NH.sub.2 or piperidin-4-yl, Cy and Ak.sub.3 are as defined in the description, R.sub.4 and R.sub.5, which may be identical or different, each represent H or F, their optical isomers, and addition salts thereof with a pharmaceutically acceptable acid. Medicinal products containing the same which are useful in treating conditions requiring a TAFIa inhibitor.
Inventor(s): Gloanec; Philippe (Marly le Roi, FR), Schaffner; Arnaud-Pierre (Marly le Roi, FR), Sansilvestri-Morel; Patricia (Antony, FR), Rupin; Alain (Savonnieres, FR), Mennecier; Philippe (Conflans Sainte Honorine, FR), Vallez; Marie-Odile (Montreuil, FR)
Assignee: LES LABORATOIRES SERVIER (Suresnes, FR)
Application Number:15/548,533
Patent Claims:see list of patent claims

Details for Patent 10,138,260

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech TNKASE tenecteplase VIAL 103909 001 2000-06-02   Start Trial LES LABORATOIRES SERVIER (Suresnes, FR) 2036-01-14 RX search
Genentech CATHFLO ACTIVASE alteplase VIAL 103172 003 1987-11-13   Start Trial LES LABORATOIRES SERVIER (Suresnes, FR) 2036-01-14 RX search
Genentech ACTIVASE alteplase VIAL; SINGLE-USE 103172 002 1987-11-13   Start Trial LES LABORATOIRES SERVIER (Suresnes, FR) 2036-01-14 RX search
Genentech ACTIVASE alteplase VIAL; SINGLE-USE 103172 001 1987-11-13   Start Trial LES LABORATOIRES SERVIER (Suresnes, FR) 2036-01-14 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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