Patent: 10,138,260
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Summary for Patent: 10,138,260
Title: | Compounds of phosphinanes and azaphosphinanes, a process for their preparation and pharmaceutical compositions containing them |
Abstract: | Compounds of formula (I) ##STR00001## wherein: Ak.sub.1 represents an alkyl chain, X represents --(CH.sub.2).sub.m--, --CH(R)--, --N(R)--, --CH.sub.2--N(R)--, --N(R)--CH.sub.2-- or --CH.sub.2--N(R)--CH.sub.2--, m and R are as defined in the description, R.sub.1 and R.sub.2 each represent H when X represents --(CH.sub.2).sub.m--, --CH(R)--, --N(R)--, --CH.sub.2--N(R)-- or --N(R)--CH.sub.2--, or together form a bond when X represents --CH.sub.2--N(R)--CH.sub.2--, R.sub.3 represents NH.sub.2, Cy-NH.sub.2, Cy-Ak.sub.3-NH.sub.2 or piperidin-4-yl, Cy and Ak.sub.3 are as defined in the description, R.sub.4 and R.sub.5, which may be identical or different, each represent H or F, their optical isomers, and addition salts thereof with a pharmaceutically acceptable acid. Medicinal products containing the same which are useful in treating conditions requiring a TAFIa inhibitor. |
Inventor(s): | Gloanec; Philippe (Marly le Roi, FR), Schaffner; Arnaud-Pierre (Marly le Roi, FR), Sansilvestri-Morel; Patricia (Antony, FR), Rupin; Alain (Savonnieres, FR), Mennecier; Philippe (Conflans Sainte Honorine, FR), Vallez; Marie-Odile (Montreuil, FR) |
Assignee: | LES LABORATOIRES SERVIER (Suresnes, FR) |
Application Number: | 15/548,533 |
Patent Claims: | see list of patent claims |
Details for Patent 10,138,260
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Genentech, Inc. | ACTIVASE | alteplase | For Injection | 103172 | 11/13/1987 | ⤷ Try a Trial | 2036-01-14 |
Genentech, Inc. | CATHFLO ACTIVASE | alteplase | For Injection | 103172 | 09/04/2001 | ⤷ Try a Trial | 2036-01-14 |
Genentech, Inc. | TNKASE | tenecteplase | For Injection | 103909 | 06/02/2000 | ⤷ Try a Trial | 2036-01-14 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |