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Last Updated: March 28, 2024

Patent: 10,138,260


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Summary for Patent: 10,138,260
Title:Compounds of phosphinanes and azaphosphinanes, a process for their preparation and pharmaceutical compositions containing them
Abstract: Compounds of formula (I) ##STR00001## wherein: Ak.sub.1 represents an alkyl chain, X represents --(CH.sub.2).sub.m--, --CH(R)--, --N(R)--, --CH.sub.2--N(R)--, --N(R)--CH.sub.2-- or --CH.sub.2--N(R)--CH.sub.2--, m and R are as defined in the description, R.sub.1 and R.sub.2 each represent H when X represents --(CH.sub.2).sub.m--, --CH(R)--, --N(R)--, --CH.sub.2--N(R)-- or --N(R)--CH.sub.2--, or together form a bond when X represents --CH.sub.2--N(R)--CH.sub.2--, R.sub.3 represents NH.sub.2, Cy-NH.sub.2, Cy-Ak.sub.3-NH.sub.2 or piperidin-4-yl, Cy and Ak.sub.3 are as defined in the description, R.sub.4 and R.sub.5, which may be identical or different, each represent H or F, their optical isomers, and addition salts thereof with a pharmaceutically acceptable acid. Medicinal products containing the same which are useful in treating conditions requiring a TAFIa inhibitor.
Inventor(s): Gloanec; Philippe (Marly le Roi, FR), Schaffner; Arnaud-Pierre (Marly le Roi, FR), Sansilvestri-Morel; Patricia (Antony, FR), Rupin; Alain (Savonnieres, FR), Mennecier; Philippe (Conflans Sainte Honorine, FR), Vallez; Marie-Odile (Montreuil, FR)
Assignee: LES LABORATOIRES SERVIER (Suresnes, FR)
Application Number:15/548,533
Patent Claims:see list of patent claims

Details for Patent 10,138,260

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. ACTIVASE alteplase For Injection 103172 11/13/1987 ⤷  Try a Trial 2036-01-14
Genentech, Inc. CATHFLO ACTIVASE alteplase For Injection 103172 09/04/2001 ⤷  Try a Trial 2036-01-14
Genentech, Inc. TNKASE tenecteplase For Injection 103909 06/02/2000 ⤷  Try a Trial 2036-01-14
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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