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Last Updated: September 28, 2020

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Patent: 10,130,686

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Summary for Patent: 10,130,686
Title:Method and composition of thyroid hormone analogues and nanoformulations thereof for treating inflammatory disorders
Abstract: Thyroid hormone antagonists and their nanoparticle formulations (Nanotetrac.TM. or Nanotriac.TM.) act at a cell surface receptor to block angiogenesis and tumor cell proliferation. The complex anti-angiogenic performs actions on specific cytokines and chemokines. Thyroid hormone antagonists inhibit expression in tumor cells of cytokine genes, e.g., specific interleukins, and chemokine genes, such as fractalkine (CX3CL1), and chemokine receptor genes (CX3CR1) that are targets in the development of inflammation-suppressant drugs. This application discloses a novel composition of Tetra or Tri-iodothyroacetic acid (tetrac or triac), other thyroid partial agonists or antagonists and their nanoparticle formulations conjugated to polymers and encapsulating non-steroidal anti-inflammatory, anti-inflammatory glucocorticoids, and/or polyphenols for the management of various acute and chronic inflammatory disorders ranging from neurological, vascular, and musculoskeletal disorders.
Inventor(s): Mousa; Shaker A. (Wynantskill, NY), Davis; Paul J. (West Sand Lake, NY)
Assignee: NANOPHARMACEUTICALS LLC (Rensselaer, NY)
Application Number:15/357,818
Patent Claims:see list of patent claims

Details for Patent 10,130,686

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial NANOPHARMACEUTICALS LLC (Rensselaer, NY) 2025-09-15 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial NANOPHARMACEUTICALS LLC (Rensselaer, NY) 2025-09-15 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial NANOPHARMACEUTICALS LLC (Rensselaer, NY) 2025-09-15 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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