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Last Updated: March 29, 2023

Patent: 10,130,686

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Summary for Patent: 10,130,686
Title:Method and composition of thyroid hormone analogues and nanoformulations thereof for treating inflammatory disorders
Abstract: Thyroid hormone antagonists and their nanoparticle formulations (Nanotetrac.TM. or Nanotriac.TM.) act at a cell surface receptor to block angiogenesis and tumor cell proliferation. The complex anti-angiogenic performs actions on specific cytokines and chemokines. Thyroid hormone antagonists inhibit expression in tumor cells of cytokine genes, e.g., specific interleukins, and chemokine genes, such as fractalkine (CX3CL1), and chemokine receptor genes (CX3CR1) that are targets in the development of inflammation-suppressant drugs. This application discloses a novel composition of Tetra or Tri-iodothyroacetic acid (tetrac or triac), other thyroid partial agonists or antagonists and their nanoparticle formulations conjugated to polymers and encapsulating non-steroidal anti-inflammatory, anti-inflammatory glucocorticoids, and/or polyphenols for the management of various acute and chronic inflammatory disorders ranging from neurological, vascular, and musculoskeletal disorders.
Inventor(s): Mousa; Shaker A. (Wynantskill, NY), Davis; Paul J. (West Sand Lake, NY)
Application Number:15/357,818
Patent Claims:see list of patent claims

Details for Patent 10,130,686

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Nps Pharmaceuticals, Inc. NATPARA parathyroid hormone For Injection 125511 01/23/2015 See Plans and Pricing 2025-09-15
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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