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Last Updated: July 26, 2021

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Patent: 10,119,131

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Summary for Patent: 10,119,131
Title:Compositions and methods for producing clostridial collagenases
Abstract: The present invention provides a method for producing a drug product comprising a combination of highly purified collagenase I and collagenase II from Clostridium histolyticum. The method utilizes an improved medium for the cultivation of Clostridium histolyticum which includes a non-meat-derived (i.e., non-mammalian) peptone or vegetable peptone. The method includes one or more of: (1) reducing glucose content in the meat-free or vegetable-derived media; and (2) increasing the salt concentration in the meat-free or vegetable-derived media. Also provided is a drug product which includes collagenase I and collagenase II at an optimized fixed mass ratio, and which has a purity of greater than at least 95%.
Inventor(s): Wegman; Thomas L. (N. Merrick, NY), Yu; Bo (Fresh Meadows, NY)
Assignee: BIOSPECIFICS TECHNOLOGIES CORP. (Lynbrook, NY)
Application Number:13/422,939
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 10,119,131
Patent Claims:see list of patent claims

Details for Patent 10,119,131

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04 ⤷  Free Forever Trial BIOSPECIFICS TECHNOLOGIES CORP. (Lynbrook, NY) 2031-03-16 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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