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Last Updated: September 24, 2022

Patent: 10,119,131

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Summary for Patent: 10,119,131
Title:Compositions and methods for producing clostridial collagenases
Abstract: The present invention provides a method for producing a drug product comprising a combination of highly purified collagenase I and collagenase II from Clostridium histolyticum. The method utilizes an improved medium for the cultivation of Clostridium histolyticum which includes a non-meat-derived (i.e., non-mammalian) peptone or vegetable peptone. The method includes one or more of: (1) reducing glucose content in the meat-free or vegetable-derived media; and (2) increasing the salt concentration in the meat-free or vegetable-derived media. Also provided is a drug product which includes collagenase I and collagenase II at an optimized fixed mass ratio, and which has a purity of greater than at least 95%.
Inventor(s): Wegman; Thomas L. (N. Merrick, NY), Yu; Bo (Fresh Meadows, NY)
Application Number:13/422,939
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 10,119,131
Patent Claims:see list of patent claims

Details for Patent 10,119,131

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Smith & Nephew, Inc. SANTYL collagenase Ointment 101995 06/04/1965 See Plans and Pricing 2031-03-16
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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