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Last Updated: December 12, 2019

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Patent: 10,117,943

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Summary for Patent: 10,117,943
Title:Synthetic antibody mimetic compounds (SYAMS) targeting cancer, especially prostate cancer
Abstract: The present invention relates to compounds which function as antibody mimetic compounds. These compounds are bifunctional/multifunctional compounds which contain at least one cancer cell binding moiety which selectively binds to prostate specific membrane antigen (PSMA) and a FC receptor binding moiety which modulates an FC immune receptor, preferably a Fc.gamma.RI receptor. Compounds according to the present invention bind selectively to cancer cells which upregulate PSMA and through that interaction, place the Fc receptor binding moiety of the compound in proximity to a Fc receptor, preferably a Fc.gamma.RI receptor, which can modulate (preferably, upregulate) a humoral response in a patient to cancer cells. Through this biological action of the compounds according to the present invention, cancer cells, including metastatic cancer cells, especially prostate cancer cells can be immune regulated, resulting in the favorable therapy of cancer in a patient. Methods of using these compounds to treat cancer and/or reduce the likelihood of metastatis of cancer are additional aspects of the present invention.
Inventor(s): Spiegel; David A. (New Haven, CT), McEnaney; Patrick (Jupiter, FL), Fitzgerald; Kelly (Upton, MA)
Assignee: YALE UNIVERSITY (New Haven, CT)
Application Number:14/888,779
Patent Claims:see list of patent claims

Details for Patent 10,117,943

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech Inc HERCEPTIN HYLECTA trastuzumab; hyaluronidase-oysk INJECTABLE;SUBCUTANEOUS 761106 001 2019-02-28   Start Trial YALE UNIVERSITY (New Haven, CT) 2039-02-26 RX search
Genentech Inc RITUXAN HYCELA rituximab; hyaluronidase (human recombinant) SOLUTION;SUBCUTANEOUS 761064 002 2017-06-22   Start Trial YALE UNIVERSITY (New Haven, CT) 2039-02-26 RX Orphan search
Genentech Inc RITUXAN HYCELA rituximab; hyaluronidase (human recombinant) SOLUTION;SUBCUTANEOUS 761064 001 2017-06-22   Start Trial YALE UNIVERSITY (New Haven, CT) 2039-02-26 RX Orphan search
Wyeth Pharms Inc MYLOTARG gemtuzumab ozogamicin VIAL;SINGLE-DOSE 761060 001 2018-04-09   Start Trial YALE UNIVERSITY (New Haven, CT) 2039-02-26 RX Orphan search
Glaxo Grp Ltd ARZERRA ofatumumab INJECTABLE; INJECTION 125326 001 2009-10-26   Start Trial YALE UNIVERSITY (New Haven, CT) 2039-02-26 RX Orphan search
Amgen NEULASTA pegfilgrastim SYRINGE 125031 001 2002-01-31   Start Trial YALE UNIVERSITY (New Haven, CT) 2039-02-26 RX Orphan search
Spectrum Pharms ZEVALIN ibritumomab tiuxetan INJECTABLE; INJECTION 125019 001 2002-02-19   Start Trial YALE UNIVERSITY (New Haven, CT) 2039-02-26 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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