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Last Updated: March 28, 2024

Patent: 10,117,943


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Summary for Patent: 10,117,943
Title:Synthetic antibody mimetic compounds (SYAMS) targeting cancer, especially prostate cancer
Abstract: The present invention relates to compounds which function as antibody mimetic compounds. These compounds are bifunctional/multifunctional compounds which contain at least one cancer cell binding moiety which selectively binds to prostate specific membrane antigen (PSMA) and a FC receptor binding moiety which modulates an FC immune receptor, preferably a Fc.gamma.RI receptor. Compounds according to the present invention bind selectively to cancer cells which upregulate PSMA and through that interaction, place the Fc receptor binding moiety of the compound in proximity to a Fc receptor, preferably a Fc.gamma.RI receptor, which can modulate (preferably, upregulate) a humoral response in a patient to cancer cells. Through this biological action of the compounds according to the present invention, cancer cells, including metastatic cancer cells, especially prostate cancer cells can be immune regulated, resulting in the favorable therapy of cancer in a patient. Methods of using these compounds to treat cancer and/or reduce the likelihood of metastatis of cancer are additional aspects of the present invention.
Inventor(s): Spiegel; David A. (New Haven, CT), McEnaney; Patrick (Jupiter, FL), Fitzgerald; Kelly (Upton, MA)
Assignee: YALE UNIVERSITY (New Haven, CT)
Application Number:14/888,779
Patent Claims:see list of patent claims

Details for Patent 10,117,943

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Recordati Rare Diseases, Inc. ELSPAR asparaginase For Injection 101063 01/10/1978 ⤷  Try a Trial 2039-02-26
Merck Teknika Llc TICE BCG bcg live For Injection 102821 06/21/1989 ⤷  Try a Trial 2039-02-26
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 ⤷  Try a Trial 2039-02-26
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try a Trial 2039-02-26
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 ⤷  Try a Trial 2039-02-26
Hoffmann-la Roche Inc. ROFERON-A interferon alfa-2a For Injection 103145 06/04/1986 ⤷  Try a Trial 2039-02-26
Amgen, Inc. EPOGEN/PROCRIT epoetin alfa Injection 103234 06/01/1989 ⤷  Try a Trial 2039-02-26
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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