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Last Updated: July 26, 2021

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Patent: 10,100,034

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Summary for Patent: 10,100,034
Title:Process for preparing an anti-cancer agent, 1-((4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)meth- yl)cyclopropanamine, its crystalline form and its salts
Abstract: The present invention relates a new process to synthesize 1-((4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)meth- yl)cyclopropanamine (AL3818). A stable crystalline form of A13818 has been prepared. Salts and their crystalline forms of AL3818 have been also prepared. Anti-cancer and optometric activities of AL3818 and its salts have been further tested. New process has been outlined in Scheme I. ##STR00001##
Inventor(s): Chen; Guoqing Paul (Westlake, CA), Yan; Changren (Camarillo, CA)
Assignee: Advenchen Pharmaceuticals, LLC (Moorpark, CA)
Application Number:15/659,510
Patent Claims:see list of patent claims

Details for Patent 10,100,034

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Janssen Biotech DARZALEX daratumumab INJECTABLE;INJECTION 761036 002 2015-11-16 ⤷  Free Forever Trial Advenchen Pharmaceuticals, LLC (Moorpark, CA) 2035-05-04 RX Orphan search
Janssen Biotech DARZALEX daratumumab INJECTABLE;INJECTION 761036 001 2015-11-16 ⤷  Free Forever Trial Advenchen Pharmaceuticals, LLC (Moorpark, CA) 2035-05-04 RX Orphan search
Bristol Myers Squibb EMPLICITI elotuzumab INJECTABLE;INJECTION 761035 002 2015-11-30 ⤷  Free Forever Trial Advenchen Pharmaceuticals, LLC (Moorpark, CA) 2035-05-04 RX Orphan search
Bristol Myers Squibb EMPLICITI elotuzumab INJECTABLE;INJECTION 761035 001 2015-11-30 ⤷  Free Forever Trial Advenchen Pharmaceuticals, LLC (Moorpark, CA) 2035-05-04 RX Orphan search
Amgen BLINCYTO blinatumomab INJECTABLE;INJECTION 125557 001 2014-12-03 ⤷  Free Forever Trial Advenchen Pharmaceuticals, LLC (Moorpark, CA) 2035-05-04 RX Orphan search
Bristol Myers Squibb OPDIVO nivolumab INJECTABLE;INJECTION 125554 001 2015-11-23 ⤷  Free Forever Trial Advenchen Pharmaceuticals, LLC (Moorpark, CA) 2035-05-04 RX Orphan search
Bristol Myers Squibb OPDIVO nivolumab INJECTABLE;INJECTION 125527 002 2015-03-04 ⤷  Free Forever Trial Advenchen Pharmaceuticals, LLC (Moorpark, CA) 2035-05-04 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 10,100,034

Country Patent Number Estimated Expiration
World Intellectual Property Organization (WIPO) 2016179123 ⤷  Free Forever Trial
United States of America 10544125 ⤷  Free Forever Trial
United States of America 2016326138 ⤷  Free Forever Trial
United States of America 2018002311 ⤷  Free Forever Trial
United States of America 2019002435 ⤷  Free Forever Trial
United States of America 9751859 ⤷  Free Forever Trial
Taiwan 201639830 ⤷  Free Forever Trial
>Country >Patent Number >Estimated Expiration

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