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Last Updated: September 24, 2022

Patent: 10,100,034


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Summary for Patent: 10,100,034
Title:Process for preparing an anti-cancer agent, 1-((4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)meth- yl)cyclopropanamine, its crystalline form and its salts
Abstract: The present invention relates a new process to synthesize 1-((4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)meth- yl)cyclopropanamine (AL3818). A stable crystalline form of A13818 has been prepared. Salts and their crystalline forms of AL3818 have been also prepared. Anti-cancer and optometric activities of AL3818 and its salts have been further tested. New process has been outlined in Scheme I. ##STR00001##
Inventor(s): Chen; Guoqing Paul (Westlake, CA), Yan; Changren (Camarillo, CA)
Assignee: Advenchen Pharmaceuticals, LLC (Moorpark, CA)
Application Number:15/659,510
Patent Claims:see list of patent claims

Details for Patent 10,100,034

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 06/30/2006 See Plans and Pricing 2035-05-04
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 08/10/2012 See Plans and Pricing 2035-05-04
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 10/13/2016 See Plans and Pricing 2035-05-04
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 03/20/2018 See Plans and Pricing 2035-05-04
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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