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Last Updated: September 24, 2020

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Patent: 10,100,034

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Summary for Patent: 10,100,034
Title:Process for preparing an anti-cancer agent, 1-((4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)meth- yl)cyclopropanamine, its crystalline form and its salts
Abstract: The present invention relates a new process to synthesize 1-((4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)meth- yl)cyclopropanamine (AL3818). A stable crystalline form of A13818 has been prepared. Salts and their crystalline forms of AL3818 have been also prepared. Anti-cancer and optometric activities of AL3818 and its salts have been further tested. New process has been outlined in Scheme I. ##STR00001##
Inventor(s): Chen; Guoqing Paul (Westlake, CA), Yan; Changren (Camarillo, CA)
Assignee: Advenchen Pharmaceuticals, LLC (Moorpark, CA)
Application Number:15/659,510
Patent Claims:see list of patent claims

Details for Patent 10,100,034

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech LUCENTIS ranibizumab INJECTABLE; INJECTION 125156 001 2006-06-30   Start Trial Advenchen Pharmaceuticals, LLC (Moorpark, CA) 2035-05-04 RX search
Bristol Myers Squibb YERVOY ipilimumab INJECTABLE; INJECTION 125377 001 2011-03-25   Start Trial Advenchen Pharmaceuticals, LLC (Moorpark, CA) 2035-05-04 RX Orphan search
Merck Sharp Dohme KEYTRUDA pembrolizumab POWDER, FOR INJECTION SOLUTION, LYOPHILIZED POWDER 125514 001 2014-09-04   Start Trial Advenchen Pharmaceuticals, LLC (Moorpark, CA) 2035-05-04 RX Orphan search
Amgen Inc IMLYGIC talimogene laherparepvec INJECTION, SUSPENSION 125518 1 2015-11-02   Start Trial Advenchen Pharmaceuticals, LLC (Moorpark, CA) 2035-05-04 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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