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Last Updated: July 26, 2021

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Patent: 10,093,732

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Summary for Patent: 10,093,732
Title:Antagonists of IL-6 to prevent or treat thrombosis
Abstract: The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat thrombosis in diseases associated with abnormal blood coagulation or fibrinolysis. In preferred embodiments these patients will comprise those exhibiting elevated D-dimer or other coagulation cascade related proteins and optionally will further exhibit elevated C reactive protein prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, et al.
Inventor(s): Smith; Jeffrey T. L. (Bellevue, WA)
Assignee: ALDERBIO HOLDINGS LLC (Las Vegas, NV)
Application Number:14/933,141
Patent Claims:see list of patent claims

Details for Patent 10,093,732

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech Inc RITUXAN HYCELA rituximab; hyaluronidase (human recombinant) SOLUTION;SUBCUTANEOUS 761064 002 2017-06-22 ⤷  Free Forever Trial ALDERBIO HOLDINGS LLC (Las Vegas, NV) 2028-11-25 RX Orphan search
Genentech Inc RITUXAN HYCELA rituximab; hyaluronidase (human recombinant) SOLUTION;SUBCUTANEOUS 761064 001 2017-06-22 ⤷  Free Forever Trial ALDERBIO HOLDINGS LLC (Las Vegas, NV) 2028-11-25 RX Orphan search
Genentech Inc OCREVUS ocrelizumab INJECTABLE;INJECTION 761053 001 2017-03-28 ⤷  Free Forever Trial ALDERBIO HOLDINGS LLC (Las Vegas, NV) 2028-11-25 RX search
Genentech PERJETA pertuzumab VIAL; SINGLE-USE 125409 001 2012-06-08 ⤷  Free Forever Trial ALDERBIO HOLDINGS LLC (Las Vegas, NV) 2028-11-25 RX search
Novartis KESIMPTA ofatumumab SOLUTION;SUBCUTANEOUS 125326 002 2009-10-26 ⤷  Free Forever Trial ALDERBIO HOLDINGS LLC (Las Vegas, NV) 2028-11-25 RX Orphan search
Novartis ARZERRA ofatumumab INJECTABLE; INJECTION 125326 001 2009-10-26 ⤷  Free Forever Trial ALDERBIO HOLDINGS LLC (Las Vegas, NV) 2028-11-25 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Baxter
Dow
Merck

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