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Last Updated: February 21, 2020

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Patent: 10,092,659

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Summary for Patent: 10,092,659
Title:Duocarmycin ADCs for use in treatment of endometrial cancer
Abstract: The present invention relates to duocarmycin-containing antibody-drug conjugates (ADCs) for use in the treatment of human solid tumors expressing HER2, wherein the human solid tumor expressing HER2 is endometrial cancer, in particular uterine serous carcinoma (USC). In particular, the present invention relates to duocarmycin-containing ADCs for use in the treatment of endometrial cancer, notably USC, with HER2 IHC 2- or 1+ and HER2 FISH negative tumor tissue status.
Inventor(s): Santin; Alessandro Davide (New Haven, CT), Goedings; Peter Johannes (Nijmegen, NL)
Assignee: Synthon Biopharmaceuticals B.V. (Nijmegen, NL) Yale University (New Haven, CT)
Application Number:15/216,366
Patent Claims:see list of patent claims

Details for Patent 10,092,659

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial Synthon Biopharmaceuticals B.V. (Nijmegen, NL) Yale University (New Haven, CT) 2034-01-10 RX Orphan search
Genentech PERJETA pertuzumab VIAL; SINGLE-USE 125409 001 2012-06-08   Start Trial Synthon Biopharmaceuticals B.V. (Nijmegen, NL) Yale University (New Haven, CT) 2034-01-10 RX search
Genentech Inc HERCEPTIN HYLECTA trastuzumab; hyaluronidase-oysk INJECTABLE;SUBCUTANEOUS 761106 001 2019-02-28   Start Trial Synthon Biopharmaceuticals B.V. (Nijmegen, NL) Yale University (New Haven, CT) 2034-01-10 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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