Patent: 10,092,542

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Summary for Patent: 10,092,542

Title:	Methods of using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoi- soindoline-1,3-dione
Abstract:	Stereomerically pure (+)-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoiso- indoline-1,3-dione, substantially free of its (-) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discussed. Also discussed are methods of using and pharmaceutical compositions comprising the (+) enantiomer of 2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoin- doline-1,3-dione are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-.alpha. or the inhibition of PDE4.
Inventor(s):	Muller; George W. (Rancho Santa Fe, CA), Schafer; Peter H. (Belle Mead, NJ), Man; Hon-Wah (Princeton, NJ), Ge; Chuansheng (Belle Mead, NJ)
Assignee:	Celgene Corporation (Summit, NJ)
Application Number:	15/629,678
Patent Claims:	see list of patent claims

Details for Patent 10,092,542

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Patent Expiration	Status	Orphan	Source
Amgen	XGEVA	denosumab	INJECTABLE; SUBCUTANEOUS	125320	002	2010-06-01	➤ Sign Up	Celgene Corporation (Summit, NJ)	➤ Sign Up	RX	Orphan	search
Amgen	PROLIA	denosumab	INJECTABLE; SUBCUTANEOUS	125320	001	2010-06-01	➤ Sign Up	Celgene Corporation (Summit, NJ)	➤ Sign Up	RX	Orphan	search
Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Patent Expiration	Status	Orphan	Source

International Patent Family for US Patent 10,092,542

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Country	Patent Number	Publication Date
South Africa	200600682	Mar 28, 2007
World Intellectual Property Organization (WIPO)	03080049	Oct 02, 2003
United States of America	2003187052	Oct 02, 2003
United States of America	2005192336	Sep 01, 2005
United States of America	2005267196	Dec 01, 2005
Country	Patent Number	Publication Date

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