Patent: 10,092,542

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Summary for Patent: 10,092,542

Title:	Methods of using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoi- soindoline-1,3-dione
Abstract:	Stereomerically pure (+)-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoiso- indoline-1,3-dione, substantially free of its (-) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discussed. Also discussed are methods of using and pharmaceutical compositions comprising the (+) enantiomer of 2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoin- doline-1,3-dione are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-.alpha. or the inhibition of PDE4.
Inventor(s):	Muller; George W. (Rancho Santa Fe, CA), Schafer; Peter H. (Belle Mead, NJ), Man; Hon-Wah (Princeton, NJ), Ge; Chuansheng (Belle Mead, NJ)
Assignee:	Celgene Corporation (Summit, NJ)
Application Number:	15/629,678
Patent Claims:	see list of patent claims

Details for Patent 10,092,542

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Estimated Patent Expiration	Status	Orphan	Source
Amgen	XGEVA	denosumab	INJECTABLE; SUBCUTANEOUS	125320	002	2010-06-01	Start Trial	Celgene Corporation (Summit, NJ)	2022-03-20	RX	Orphan	search
Amgen	PROLIA	denosumab	INJECTABLE; SUBCUTANEOUS	125320	001	2010-06-01	Start Trial	Celgene Corporation (Summit, NJ)	2022-03-20	RX	Orphan	search
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Number	>Approval Date	>Patent No.	>Assignee	>Estimated Patent Expiration	>Status	>Orphan	>Source

International Patent Family for US Patent 10,092,542

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Country	Patent Number	Publication Date
South Africa	200600682	Mar 28, 2007
World Intellectual Property Organization (WIPO)	03080049	Oct 02, 2003
United States of America	2003187052	Oct 02, 2003
>Country	>Patent Number	>Publication Date

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