Patent: 10,087,237

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Summary for Patent: 10,087,237

Title:	Isoform enriched antibody preparation and method for obtaining it
Abstract:	Herein is reported a method for producing an antibody preparation comprising the steps of a) applying a buffered solution comprising different isoforms of an antibody to a cation exchange chromatography material, b) applying a first solution with a first conductivity to the cation exchange chromatography material, whereby the antibody isoforms remain bound to the cation exchange chromatography material, and c) applying a second solution with a second conductivity to the cation exchange chromatography material and thereby obtaining the antibody preparation, whereby the conductivity of the second solution exceeds the conductivity of the first solution by not more than 10%.
Inventor(s):	Falkenstein; Roberto (Munich, DE), Schwendner; Klaus (Weilheim, DE), Spensberger; Bernhard (Eberfing, DE)
Assignee:	F. HOFFMANN-LA ROCHE AG (Nutley, NJ)
Application Number:	14/934,866
Patent Claims:	see list of patent claims

Details for Patent 10,087,237

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Estimated Patent Expiration	Status	Orphan	Source
Genentech	PERJETA	pertuzumab	VIAL; SINGLE-USE	125409	001	2012-06-08	Try a Free Trial	F. HOFFMANN-LA ROCHE AG (Nutley, NJ)	2030-12-21	RX		search
Genentech	HERCEPTIN	trastuzumab	VIAL; INTRAVENOUS	103792	001	1998-09-25	Try a Free Trial	F. HOFFMANN-LA ROCHE AG (Nutley, NJ)	2030-12-21	RX	Orphan	search
Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Estimated Patent Expiration	Status	Orphan	Source

International Patent Family for US Patent 10,087,237

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Country	Patent Number	Publication Date
World Intellectual Property Organization (WIPO)	2012084829	Jun 28, 2012
United States of America	2014162317	Jun 12, 2014
United States of America	2017066814	Mar 09, 2017
Russian Federation	2013132405	Jan 27, 2015
Country	Patent Number	Publication Date

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