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Generated: August 19, 2019

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Patent: 10,087,237

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Summary for Patent: 10,087,237
Title:Isoform enriched antibody preparation and method for obtaining it
Abstract: Herein is reported a method for producing an antibody preparation comprising the steps of a) applying a buffered solution comprising different isoforms of an antibody to a cation exchange chromatography material, b) applying a first solution with a first conductivity to the cation exchange chromatography material, whereby the antibody isoforms remain bound to the cation exchange chromatography material, and c) applying a second solution with a second conductivity to the cation exchange chromatography material and thereby obtaining the antibody preparation, whereby the conductivity of the second solution exceeds the conductivity of the first solution by not more than 10%.
Inventor(s): Falkenstein; Roberto (Munich, DE), Schwendner; Klaus (Weilheim, DE), Spensberger; Bernhard (Eberfing, DE)
Assignee: F. HOFFMANN-LA ROCHE AG (Nutley, NJ)
Application Number:14/934,866
Patent Claims:see list of patent claims

Details for Patent 10,087,237

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech PERJETA pertuzumab VIAL; SINGLE-USE 125409 001 2012-06-08   Try a Free Trial F. HOFFMANN-LA ROCHE AG (Nutley, NJ) 2030-12-21 RX search
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Try a Free Trial F. HOFFMANN-LA ROCHE AG (Nutley, NJ) 2030-12-21 RX Orphan search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source

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