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Last Updated: January 27, 2023

Patent: 10,087,237


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Summary for Patent: 10,087,237
Title:Isoform enriched antibody preparation and method for obtaining it
Abstract: Herein is reported a method for producing an antibody preparation comprising the steps of a) applying a buffered solution comprising different isoforms of an antibody to a cation exchange chromatography material, b) applying a first solution with a first conductivity to the cation exchange chromatography material, whereby the antibody isoforms remain bound to the cation exchange chromatography material, and c) applying a second solution with a second conductivity to the cation exchange chromatography material and thereby obtaining the antibody preparation, whereby the conductivity of the second solution exceeds the conductivity of the first solution by not more than 10%.
Inventor(s): Falkenstein; Roberto (Munich, DE), Schwendner; Klaus (Weilheim, DE), Spensberger; Bernhard (Eberfing, DE)
Assignee: F. HOFFMANN-LA ROCHE AG (Nutley, NJ)
Application Number:14/934,866
Patent Claims:see list of patent claims

Details for Patent 10,087,237

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 09/25/1998 See Plans and Pricing 2030-12-21
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 02/10/2017 See Plans and Pricing 2030-12-21
Genentech, Inc. PERJETA pertuzumab Injection 125409 06/08/2012 See Plans and Pricing 2030-12-21
Genentech, Inc. HERCEPTIN HYLECTA trastuzumab and hyaluronidase-oysk Injection 761106 02/28/2019 See Plans and Pricing 2030-12-21
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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