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Patent: 10,087,237

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Summary for Patent: 10,087,237

Title:	Isoform enriched antibody preparation and method for obtaining it
Abstract:	Herein is reported a method for producing an antibody preparation comprising the steps of a) applying a buffered solution comprising different isoforms of an antibody to a cation exchange chromatography material, b) applying a first solution with a first conductivity to the cation exchange chromatography material, whereby the antibody isoforms remain bound to the cation exchange chromatography material, and c) applying a second solution with a second conductivity to the cation exchange chromatography material and thereby obtaining the antibody preparation, whereby the conductivity of the second solution exceeds the conductivity of the first solution by not more than 10%.
Inventor(s):	Falkenstein; Roberto (Munich, DE), Schwendner; Klaus (Weilheim, DE), Spensberger; Bernhard (Eberfing, DE)
Assignee:	F. HOFFMANN-LA ROCHE AG (Nutley, NJ)
Application Number:	14/934,866
Patent Claims:	see list of patent claims

Details for Patent 10,087,237

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Estimated Patent Expiration	Status	Orphan	Source
Genentech	HERCEPTIN	trastuzumab	VIAL; INTRAVENOUS	103792	001	1998-09-25		F. HOFFMANN-LA ROCHE AG (Nutley, NJ)	2030-12-21	RX	Orphan	search
Genentech	PERJETA	pertuzumab	VIAL; SINGLE-USE	125409	001	2012-06-08		F. HOFFMANN-LA ROCHE AG (Nutley, NJ)	2030-12-21	RX		search
Genentech Inc	HERCEPTIN HYLECTA	trastuzumab; hyaluronidase-oysk	INJECTABLE;SUBCUTANEOUS	761106	001	2019-02-28		F. HOFFMANN-LA ROCHE AG (Nutley, NJ)	2030-12-21	RX		search

International Patent Family for US Patent 10,087,237

Country	Patent Number	Estimated Expiration
Brazil	112013012422
Canada	2820095
China	103380144
European Patent Office	2655412
Hong Kong	1186484
Japan	2014500289
Japan	5838221