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Last Updated: October 6, 2022

Patent: 10,086,089

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Summary for Patent: 10,086,089
Title:Systems and methods for nucleic acid expression in vivo
Abstract: The present invention provides compositions, systems, kits, and methods for generating expression of one or more proteins and/or biologically active nucleic acid molecules in a subject (e.g., at therapeutic levels for extended periods required to produce therapeutic effects). In certain embodiments, systems and kits are provided that comprise a first composition comprising a first amount of polycationic structures, and a second composition comprising a therapeutically effective amount of expression vectors (e.g., non-viral expression vectors not associated with liposomes) that are CpG-free or CpG-reduced, where the expression vectors comprise a first nucleic acid sequence encoding: i) a first therapeutic protein or proteins, and/or ii) a first biologically active nucleic acid molecule or molecules.
Inventor(s): Debs; Robert James (San Francisco, CA), Heath; Timothy D. (Madison, WI), Handumrongkul; Chakkrapong (Richmond, VA)
Assignee: DNARx (San Francisco, CA)
Application Number:15/268,000
Patent Claims:see list of patent claims

Details for Patent 10,086,089

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. RITUXAN rituximab Injection 103705 11/26/1997 See Plans and Pricing 2035-09-18
Genentech, Inc. RITUXAN HYCELA rituximab and hyaluronidase human Injection 761064 06/22/2017 See Plans and Pricing 2035-09-18
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Serving leading biopharmaceutical companies globally:

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