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Last Updated: October 27, 2020

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Patent: 10,077,318

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Summary for Patent: 10,077,318
Title:Cysteine engineered antibodies and conjugates
Abstract: Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody; expressing the cysteine engineered antibody; and isolating the cysteine engineered antibody.
Inventor(s): Bhakta; Sunil (San Ramon, CA), Erickson; Hans (South San Francisco, CA), Junutula; Jagath R. (Fremont, CA), Kozak; Katherine (Half Moon Bay, CA), Ohri; Rachana (South San Francisco, CA), Pillow; Thomas (San Francisco, CA)
Assignee: Genentech, Inc. (South San Francisco, CA)
Application Number:14/851,348
Patent Claims:see list of patent claims

Details for Patent 10,077,318

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech Inc HERCEPTIN HYLECTA trastuzumab; hyaluronidase-oysk INJECTABLE;SUBCUTANEOUS 761106 001 2019-02-28   Start Trial Genentech, Inc. (South San Francisco, CA) 2034-09-12 RX search
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial Genentech, Inc. (South San Francisco, CA) 2034-09-12 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

Boehringer Ingelheim
AstraZeneca
Medtronic
Johnson and Johnson
Express Scripts
Colorcon

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