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Last Updated: September 22, 2020

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Patent: 10,071,171

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Summary for Patent: 10,071,171
Title:Polypeptide complex comprising non-peptidyl polymer having three functional ends
Abstract: Disclosed is a protein complex, comprising a physiologically active polypeptide, a dimeric protein and a non-peptidyl polymer having three functional ends (3-arm), with the linkage of both the physiologically active polypeptide and the dimeric protein to the 3-arm non-peptidyl polymer via respective covalent bonds. The protein complex guarantees the long acting activity and biostability of a physiologically active polypeptide. Having the ability to maintain the bioactivity of physiologically active polypeptides or peptides highly and to significantly improve the serum half life of the polypeptides or peptides, the protein complex can be applied to the development of sustained release formulations of various physiologically active polypeptide drugs. Also, it utilizes raw materials including the physiologically active polypeptides without significant loss, thereby increasing the production yield. Further, it can be easily purified.
Inventor(s): Song; Dae Hae (Seoul, KR), Shin; Jae Hee (Suwon-si, KR), Lee; Mi Ji (Incheon, KR), Hong; Sung Hee (Suwon-si, KR), Kwon; Se Chang (Seoul, KR), Lee; Gwan Sun (Seoul, KR)
Assignee: HANMI SCIENCE CO., LTD. (Hwaseong-si, KR)
Application Number:14/873,321
Patent Claims:see list of patent claims

Details for Patent 10,071,171

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 001 1978-01-16   Start Trial HANMI SCIENCE CO., LTD. (Hwaseong-si, KR) 2028-07-23 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 002 1978-01-16   Start Trial HANMI SCIENCE CO., LTD. (Hwaseong-si, KR) 2028-07-23 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 003 1978-01-16   Start Trial HANMI SCIENCE CO., LTD. (Hwaseong-si, KR) 2028-07-23 DISCN search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial HANMI SCIENCE CO., LTD. (Hwaseong-si, KR) 2028-07-23 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial HANMI SCIENCE CO., LTD. (Hwaseong-si, KR) 2028-07-23 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial HANMI SCIENCE CO., LTD. (Hwaseong-si, KR) 2028-07-23 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial HANMI SCIENCE CO., LTD. (Hwaseong-si, KR) 2028-07-23 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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