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Last Updated: October 6, 2022

Patent: 10,071,166


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Summary for Patent: 10,071,166
Title:Protein complex using an immunoglobulin fragment and method for the preparation thereof
Abstract: Disclosed are a protein conjugate with improved in vivo duration and stability and the use thereof. The protein conjugate includes a physiologically active polypeptide, a non-peptide polymer and an immunoglobulin Fc fragment. Since the three components are covalently linked, the protein conjugate has extended in vivo duration and enhanced stability for the physiologically active polypeptide. The protein conjugate maintains the in vivo activity at relatively high levels and remarkably increases the serum half-life for the physiologically active polypeptide, with less risk of inducing undesirable immune responses. Thus, the protein conjugate is useful for developing long-acting formulations of various polypeptide drugs.
Inventor(s): Kim; Young Min (Yongin-si, KR), Kim; Dae Jin (Seoul, KR), Bae; Sung Min (Seoul, KR), Lim; Chang Ki (Suwon-si, KR), Kwon; Se Chang (Seoul, KR), Lee; Gwan Sun (Seoul, KR)
Assignee: HANMI SCIENCE CO., LTD. (Hwaseong-si, KR)
Application Number:13/796,135
Patent Claims:see list of patent claims

Details for Patent 10,071,166

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Microbix Biosystems Inc. KINLYTIC urokinase For Injection 021846 01/16/1978 See Plans and Pricing 2023-11-13
Smith & Nephew, Inc. SANTYL collagenase Ointment 101995 06/04/1965 See Plans and Pricing 2023-11-13
Nps Pharmaceuticals, Inc. NATPARA parathyroid hormone For Injection 125511 01/23/2015 See Plans and Pricing 2023-11-13
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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