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Last Updated: February 7, 2023

Patent: 10,040,867


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Summary for Patent: 10,040,867
Title:Cell penetrating anti-guanosine antibody based therapy for cancers with Ras mutations
Abstract: It has been established that cancer cells with oncogenic mutants in the small GTPase K-Ras are susceptible to antibodies that bind intracellular guanosine, but delivery of antibodies into cells can be challenging. A subset of lupus autoantibodies is associated with anti-guanosine activity, and is capable of cellular penetration. These antibodies have potential as therapeutic agents targeted towards K-Ras associated malignancies.
Inventor(s): Hansen; James E. (Guilford, CT), Weisbart; Richard H. (Los Angeles, CA), Young; Melissa (New Haven, CT), Noble; Philip W. (New Haven, CT)
Assignee: Yale University (New Haven, CT) The United States of America, as Represented by The Department of Veterans Affairs (Washington, DC)
Application Number:15/123,195
Patent Claims:see list of patent claims

Details for Patent 10,040,867

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. RITUXAN rituximab Injection 103705 11/26/1997 See Plans and Pricing 2034-03-04
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 09/25/1998 See Plans and Pricing 2034-03-04
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 02/10/2017 See Plans and Pricing 2034-03-04
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Serving leading biopharmaceutical companies globally:

Mallinckrodt
Johnson and Johnson
McKinsey
Express Scripts
Harvard Business School
Colorcon

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