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Last Updated: September 29, 2020

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Patent: 10,031,127

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Summary for Patent: 10,031,127
Title:Method for separating aggregates of malignant cells and aggregates from stromal cells of a malignant tumour tissue sample
Abstract: An ex vivo malignant tumor tissue sample is cleaned, comminuted, suspended in culture medium, subjected to a treatment with collagenase and the collagenase decomposition product is centrifuged. The pellet obtained is re-suspended in culture medium by an absorption instrument, is absorbed and returned several times and transferred to a culture vessel. The re-suspension thus obtained is analyzed under a microscope with phase optics for cell aggregates, which, due to the phenotypic appearance thereof, are identifiable as an aggregate of malignant cells or as an aggregate of endothelial cells or as an aggregate of fibroblasts, and the identified cell aggregates are separated.
Inventor(s): Granzow; Christof (Heidelberg, DE)
Assignee: FLACOD GmbH (Heidelberg, DE)
Application Number:14/372,243
Patent Claims:see list of patent claims

Details for Patent 10,031,127

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial FLACOD GmbH (Heidelberg, DE) 2032-02-28 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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