Last Updated: August 9, 2026

Patent: 10,030,238

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Summary for Patent: 10,030,238

Title:	Recombinant clostridium botulinum neurotoxins
Abstract:	The invention provides a nucleic acid sequence comprising a sequence of contiguous nucleotides, wherein said sequence of contiguous nucleotides has at least 90% sequence identity to the nucleic acid sequence of SEQ ID NO: 1, and wherein said sequence of contiguous nucleotides encodes a single-chain BoNT/E1 protein. The present invention also provides methods for producing soluble single-chain BoNT/E1 protein in an E. coli host cell, together with methods for producing soluble di-chain BoNT/E1 protein.
Inventor(s):	Cossins; Aimee (Abingdon, GB), Beard; Matthew (Abingdon, GB), Marks; Philip (Wrexham, GB)
Assignee:	IPSEN BIOINNOVATION LIMITED (Abingdon, Oxfordshire, GB) IPSEN BIOPHARM LIMITED (Slough, Berkshire, GB)
Application Number:	14/427,234
Patent Claims:	see list of patent claims

Details for Patent 10,030,238

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Llc	ZOSTAVAX	zoster vaccine live	For Injection	125123	May 25, 2006	10,030,238	2033-10-31
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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