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Generated: August 25, 2019

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Patent: 10,028,993

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Summary for Patent: 10,028,993
Title:Method of reducing titers of antibodies specific for a therapeutic agent
Abstract: The present invention relates, in general, to a method of treating patients undergoing enzyme replacement therapy (ERT) or other therapy involving the administration of a proteinaceous therapeutic agent as well gene replacement therapy with non-viral or viral vectors, or other therapeutic modality or modalities, used alone or in combination, which involve the administration of exogenous substances for potential therapeutic benefit, including, but not limited to DNA vaccines, siRNA, splice-site switching oligomers (SSOs) as well as RNA-based nanoparticles (RNPs) and nanovaccines. The invention further relates to compounds and compositions suitable for use in such methods.
Inventor(s): Kishnani; Priya S. (Durham, NC), Banugaria; Suhrad G. (Durham, NC), Koeberl; Dwight D. (Durham, NC), Prater; Sean N. (Durham, NC)
Assignee: Duke University (Durham, NC)
Application Number:15/438,375
Patent Claims:see list of patent claims

Details for Patent 10,028,993

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech RITUXAN rituximab VIAL 103705 001 1997-11-26   Try a Free Trial Duke University (Durham, NC) 2030-05-06 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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International Patent Family for US Patent 10,028,993

Country Patent Number Publication Date
World Intellectual Property Organization (WIPO) 2011139379 Mar 29, 2012
World Intellectual Property Organization (WIPO) 2011139379 Nov 10, 2011
United States of America 2013052189 Feb 28, 2013
United States of America 2015037329 Feb 05, 2015
United States of America 2017165316 Jun 15, 2017
United States of America 2018117111 May 03, 2018
United States of America 8809282 Aug 19, 2014
>Country >Patent Number >Publication Date

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