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Generated: September 22, 2019

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Patent: 10,007,766

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Summary for Patent: 10,007,766
Title:Predictive test for melanoma patient benefit from antibody drug blocking ligand activation of the T-cell programmed cell death 1 (PD-1) checkpoint protein and classifier development methods
Abstract: A method is disclosed of predicting cancer patient response to immune checkpoint inhibitors, e.g., an antibody drug blocking ligand activation of programmed cell death 1 (PD-1) or CTLA4. The method includes obtaining mass spectrometry data from a blood-based sample of the patient, obtaining integrated intensity values in the mass spectrometry data of a multitude of pre-determined mass-spectral features; and operating on the mass spectral data with a programmed computer implementing a classifier. The classifier compares the integrated intensity values with feature values of a training set of class-labeled mass spectral data obtained from a multitude of melanoma patients with a classification algorithm and generates a class label for the sample. A class label \"early\" or the equivalent predicts the patient is likely to obtain relatively less benefit from the antibody drug and the class label \"late\" or the equivalent indicates the patient is likely to obtain relatively greater benefit from the antibody drug.
Inventor(s): Roder; Joanna (Steamboat Springs, CO), Meyer; Krista (Steamboat Springs, CO), Grigorieva; Julia (Steamboat Springs, CO), Tsypin; Maxim (Steamboat Springs, CO), Oliveira; Carlos (Steamboat Springs, CO), Steingrimsson; Arni (Steamboat Springs, CO), Roder; Heinrich (Steamboat Springs, CO), Asmellash; Senait (Denver, CO), Sayers; Kevin (Denver, CO), Maher; Caroline (Denver, CO), Weber; Jeffrey (New York, NY)
Assignee: Biodesix, Inc. (Boulder, CO)
Application Number:15/207,825
Patent Claims:see list of patent claims

Details for Patent 10,007,766

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Bristol Myers Squibb OPDIVO nivolumab INJECTABLE;INJECTION 125527 001 2015-03-04   Try a Free Trial Biodesix, Inc. (Boulder, CO) 2035-07-13 RX search
Bristol Myers Squibb OPDIVO nivolumab INJECTABLE;INJECTION 125527 002 2015-03-04   Try a Free Trial Biodesix, Inc. (Boulder, CO) 2035-07-13 RX search
Bristol Myers Squibb OPDIVO nivolumab INJECTABLE;INJECTION 125554 001 2015-11-23   Try a Free Trial Biodesix, Inc. (Boulder, CO) 2035-07-13 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 10,007,766

Country Patent Number Publication Date
China 108027373 May 11, 2018
European Patent Office 3322987 Mar 20, 2019
European Patent Office 3322987 May 23, 2018
United States of America 2017039345 Feb 09, 2017
United States of America 2018277249 Sep 27, 2018
United States of America 2019018929 Jan 17, 2019
World Intellectual Property Organization (WIPO) 2017011439 Jan 19, 2017
>Country >Patent Number >Publication Date

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