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Last Updated: September 22, 2020

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Patent: 10,001,489

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Summary for Patent: 10,001,489
Title:Method for constructing a novel affinity peptide library for binding immunoglobulin G based on a protein affinity model of protein A
Abstract: An affinity ligand peptide library of IgG constructed on the basis of Protein A affinity model and the application of a design method thereof. According to the Molecular Mechanics--Poisson-Boltzmann surface area (MM/PBSA) method and on the basis of the known human IgG-Protein A complex structure, the hot spots of Protein A that have high affinity for human IgG are obtained analytically, and a Protein A simplified affinity model is built thereof. An affinity peptide library of IgG is constructed including heptapeptide and octapeptide structural modes. On the basis of the peptide structural modes, the types of inserted amino acids that `X` residues represent are further identified using amino acid location method. Then, molecular docking and molecular dynamics simulation methods are used to screen the candidate peptides successively. Finally, the affinity peptide ligands that can effectively purify IgG are identified using affinity chromatography.
Inventor(s): Sun; Yan (Tianjin, CN), Zhao; Weiwei (Tianjin, CN), Liu; Fufeng (Tianjin, CN), Shi; Qinghong (Tianjin, CN)
Assignee: TIANJIN UNIVERSITY (Tianjin, CN)
Application Number:14/654,731
Patent Claims:see list of patent claims

Details for Patent 10,001,489

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Csl Behring Ag CARIMUNE human immunoglobulin g INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 102367 1 2009-02-10   Start Trial TIANJIN UNIVERSITY (Tianjin, CN) 2032-12-20 search
Csl Behring Ag PRIVIGEN human immunoglobulin g LIQUID 125201 1 2009-01-20   Start Trial TIANJIN UNIVERSITY (Tianjin, CN) 2032-12-20 search
Bio Products Laboratory Limited GAMMAPLEX human immunoglobulin g SOLUTION 125329 1 2017-04-07   Start Trial TIANJIN UNIVERSITY (Tianjin, CN) 2032-12-20 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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