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Last Updated: April 25, 2024

Claims for Patent: 9,987,271


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Summary for Patent: 9,987,271
Title:Method of treating nasopharyngeal carcinoma using perillyl alcohol derivative
Abstract: A method of treating nasopharyngeal carcinoma in a mammal includes delivering to the mammal a therapeutically effective amount of a perillyl alcohol (POH) carbamate which is a perillyl alcohol conjugated with temozolomide (TMZ).
Inventor(s): Chen; Thomas (La Canada, CA)
Assignee: NeOnc Technologies, Inc. (Los Angeles, CA)
Application Number:15/429,556
Patent Claims:1. A method for treating oral cavity cancer in a mammal, the method comprising administering to the mammal a therapeutically effective amount of a perillyl alcohol carbamate, wherein the perillyl alcohol carbamate comprises perillyl alcohol conjugated with temozolomide (TMZ).

2. The method of claim 1, wherein the oral cavity cancer is pharyngeal cancer.

3. The method of claim 2, wherein the pharyngeal cancer is nasopharyngeal carcinoma.

4. The method of claim 1, further comprising treating the mammal with radiation.

5. The method of claim 1, further comprising administering to the mammal one or more chemotherapeutic agents.

6. The method of claim 5, wherein the chemotherapeutic agent is selected from the group consisting of Rituximab, Beuacizumab, Trastuzumab, Imaninib, Lenalidomide, Pemetrexed, Bortezomib, Cetuximab, Leuprorelin, Abiraterone, 5-Fluorouracil, Doxorubicin, Epirubicin, Gemeitabine, Methotrexate, all trans Retinoic Acid, Azacitidine, Azathioprine, Bleomycin, Carboplatin, Capecitabine, Cisplatin, Chlorambucil, Cyclophosphoramide, Cytarabine, Daunorubicin, Docetaxel, Doxifluridine, Epothilone, Etoposide, Hydroxyurea, Idarubicin, Irinotecan, Mechlorethamine, Mercaptopurine, Mitoxantrone, Oxaliplatin, Paclitaxel, Teniposide, Tioguanine, Topotecan, Valrubicin, Vincristine, Vinblastine, Vindesine, Vinorelbine and combinations thereof.

7. The method of claim 1, wherein the perillyl alcohol carbamate is administered by inhalation, orally, intravenously, subcutaneously or intramuscularly.

8. The method of claim 7, wherein the perillyl alcohol carbamate is administered intranasally using an atomizer.

9. The method of claim 1, wherein the perillyl alcohol carbamate is 3-methyl 4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonyl)-ca- rbamic acid-4-isopropenyl cyclohex-1-enylmethyl ester.

10. The method of claim 1, wherein the perillyl alcohol carbamate is administered by a nasal delivery device.

11. The method of claim 10, wherein the nasal delivery device is selected from the group consisting of an intranasal inhaler, an intranasal spray device, an atomizer, a nebulizer, a metered dose inhaler (MDI), a pressurized dose inhaler, an insufflator, a unit dose container, a pump, a dropper, a nasal spray bottle, a squeeze bottle and a bi-directional device.

Details for Patent 9,987,271

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. RITUXAN rituximab Injection 103705 11/26/1997 ⤷  Try a Trial 2034-10-27
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 09/25/1998 ⤷  Try a Trial 2034-10-27
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 02/10/2017 ⤷  Try a Trial 2034-10-27
Eli Lilly And Company ERBITUX cetuximab Injection 125084 02/12/2004 ⤷  Try a Trial 2034-10-27
Eli Lilly And Company ERBITUX cetuximab Injection 125084 03/28/2007 ⤷  Try a Trial 2034-10-27
Genentech, Inc. RITUXAN HYCELA rituximab and hyaluronidase human Injection 761064 06/22/2017 ⤷  Try a Trial 2034-10-27
Genentech, Inc. HERCEPTIN HYLECTA trastuzumab and hyaluronidase-oysk Injection 761106 02/28/2019 ⤷  Try a Trial 2034-10-27
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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