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Last Updated: January 23, 2020

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Claims for Patent: 9,969,683

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Summary for Patent: 9,969,683
Title:Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
Abstract: This invention relates to the treatment of breast cancer in a subject, for example a female subject. The breast cancer includes metastatic breast cancer, refractory breast cancer, AR-positive breast cancer, AR-positive refractory breast cancer, AR-positive metastatic breast cancer, AR-positive and ER-positive breast cancer, triple negative breast cancer, advanced breast cancer, breast cancer that has failed SERM (tamoxifen, toremifene), aromatase inhibitor, trastuzumab (Herceptin, ado-trastuzumab emtansine), pertuzumab (Perjeta), lapatinib, exemestane (Aromasin), bevacizumab (Avastin), and/or fulvestrant treatments, and metastasis in a subject suffering from breast cancer. The method comprises administering to the subject a therapeutically effective amount of a selective androgen receptor modulator (SARM) compound.
Inventor(s): Dalton; James T. (Lakeland, TN), Steiner; Mitchell S. (Germantown, TN), Narayanan; Ramesh (Cordova, TN), Ahn; Sunjoo (Daejeon, KR)
Assignee: GTX, INC. (Memphis, TN)
Application Number:13/953,492
Patent Claims:1. A method of treating a subject suffering from refractory ER-positive breast cancer, comprising administering to said subject a selective androgen receptor modulator (SARM) compound represented by a structure of formula VIII or formula IX: ##STR00058## wherein said treating does not include preventing.

2. The method of claim 1, wherein said refractory ER-positive breast cancer is a breast cancer that has failed selective estrogen receptor modulator (tamoxifen, toremifene), aromatase inhibitor, trastuzumab, ado-trastuzumab emtansine, pertuzumab, lapatinib, exemestane, bevacizumab, and/or fulvestrant treatments.

3. The method of claim 1, wherein said refractory ER-positive breast cancer is refractory AR-positive ER-positive breast cancer.

4. The method of claim 1, wherein said refractory ER-positive breast cancer is AR-positive, PR-positive and HER2-negative and wherein the structure is formula IX.

5. The method of claim 1, wherein said refractory ER-positive breast cancer is AR-positive, PR-negative and HER2-positive.

6. The method of claim 1, wherein said refractory ER-positive breast cancer is AR-positive, PR-positive and HER2-positive.

7. The method of claim 1, comprising administering an isomer, a racemic mixture containing a SARM compound, a metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or crystal of said selective androgen receptor modulator, or any combination thereof.

8. The method of claim 7, wherein said administering comprises intravenously, intraarterially, or intramuscularly injecting to said subject said pharmaceutical product in liquid form; subcutaneously implanting in said subject a pellet containing said pharmaceutical product; orally administering to said subject said pharmaceutical product in a liquid or solid form; or topically applying to said subject said pharmaceutical product.

9. The method of claim 8, wherein said pharmaceutical product is a pellet, a tablet, a capsule, a solution, a suspension, an emulsion, an elixir, a gel, a cream, a suppository or a parenteral formulation.

Details for Patent 9,969,683

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial GTX, INC. (Memphis, TN) 2032-07-13 RX Orphan search
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 001 2004-02-26   Start Trial GTX, INC. (Memphis, TN) 2032-07-13 RX Orphan search
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 002 2004-02-26   Start Trial GTX, INC. (Memphis, TN) 2032-07-13 RX Orphan search
Genentech PERJETA pertuzumab VIAL; SINGLE-USE 125409 001 2012-06-08   Start Trial GTX, INC. (Memphis, TN) 2032-07-13 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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