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Last Updated: April 25, 2024

Claims for Patent: 9,968,660

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Summary for Patent: 9,968,660

Title:	Method of bone regeneration or bone augmentation
Abstract:	The present invention provides a means effective for bone regeneration or bone augmentation. Provided is a method of bone regeneration or bone augmentation, comprising: implanting a porous composite at a site in need of the bone regeneration or bone augmentation, and administering parathyroid hormone (PTH) to a subject in need of the bone regeneration or bone augmentation, wherein the porous composite comprises calcium phosphate.
Inventor(s):	Kamakura; Shinji (Sendai, JP), Nakajou; Satoru (Sendai, JP), Iwai; Atsushi (Otsu, JP), Kajii; Fumihiko (Otsu, JP), Tanaka; Hidenori (Otsu, JP)
Assignee:	TOYOBO CO., LTD. (Osaka-shi, JP)
Application Number:	15/094,724
Patent Claims:	1. A method of bone regeneration or bone augmentation, comprising: implanting a porous composite at a site in need of the bone regeneration or bone augmentation, and administering parathyroid hormone (PTH) to a subject in need of the bone regeneration or bone augmentation, wherein the porous composite comprises octacalcium phosphate (OCP) and collagen, and wherein the PTH is wild-type PTH or a derivative of wild-type PTH having the same physiological function as wild-type PTH. 2. The method of claim 1, wherein the porous composite is implanted, and then the PTH is administered. 3. The method of claim 2, wherein the PTH is administered topically to the site in need of the bone regeneration or bone augmentation. 4. The method of claim 3, wherein the PTH is administered topically to the site where the porous composite has been implanted. 5. The method of claim 1, wherein the PTH is administered subcutaneously. 6. The method of claim 1, wherein the PTH is administered to the subject, and then the porous composite is implanted. 7. The method of claim 6, wherein the PTH is administered topically to the site in need of the bone regeneration or bone augmentation. 8. The method of claim 6, wherein the PTH is administered subcutaneously. 9. The method of claim 1, wherein the site in need of the bone regeneration or bone augmentation is a site in need of the bone regeneration. 10. The method of claim 9, wherein the site in need of the bone regeneration is a site of bone defect. 11. The method of claim 1, wherein the site in need of the bone regeneration or bone augmentation is a site in need of the bone augmentation. 12. The method of claim 11, wherein the site in need of the bone augmentation is a site in need of at least one selected from the group consisting of sinus lift, bone graft, and ridge expansion. 13. The method of claim 1, wherein the PTH is teriparatide. 14. A method of bone regeneration or bone augmentation, comprising: implanting a porous composite at a site in need of the bone regeneration or bone augmentation, wherein the porous composite comprises octacalcium phosphate (OCP) and collagen and parathyroid hormone (PTH), and wherein the PTH is wild-type PTH or a derivative of wild-type PTH having the same physiological function as wild-type PTH. 15. The method of claim 14, wherein the site in need of the bone regeneration or bone augmentation is a site in need of the bone regeneration. 16. The method of claim 15, wherein the site in need of the bone regeneration is a site of bone defect. 17. The method of claim 14, wherein the site in need of the bone regeneration or bone augmentation is a site in need of the bone augmentation. 18. The method of claim 17, wherein the site in need of bone augmentation is a site in need of at least one selected from the group consisting of sinus lift, bone graft, and ridge expansion. 19. The method of claim 14, wherein the PTH is teriparatide.

Details for Patent 9,968,660

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015	⤷ Try a Trial	2039-02-26
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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