Claims for Patent: 9,907,797

Summary for Patent: 9,907,797

Title:	Combination therapies for overcoming resistance to mitotic agents during chemotherapy
Abstract:	This disclosure relates to the uses of compounds that target an interaction between CHFR and PARP1. In certain embodiments, the disclosure relate to treating cancer by administering a mitotic inhibitor such as a taxane and a vinca alkaloid in combination with a compound that inhibits CHFR and PARP1 interactions, such as 5-((1-benzyl-1H-indol-3-yl)methylene)-1-(3,4-dimethylphenyl)pyrimidine-2,- 4,6(1H,3H,5H)-trione, derivatives or salts thereof, optionally in further combination with a third anti-cancer agent.
Inventor(s):	Brandes; Johann C (Atlanta, GA)
Assignee:	Emory University (Atlanta, GA)
Application Number:	14/877,203
Patent Claims:	1. A method of treating lung cancer comprising administering an effective amount of 5-((1-benzyl-1 H-indol-3 -yl)methylene)-1-(3,4- dimethylphenyl)pyrimidine-2,4,6(1H,3H, 5H)-trione or salts thereof in combination with a taxane selected from paclitaxel and docetaxel to a subject in need thereof. 2. A method of treating breast cancer comprising administering an effective amount of 5-((1-benzyl-1 H-indol-3 -yl)methylene)-1-(3,4- dimethylphenyl)pyrimidine-2,4,6(1H,3H, 5H)-trione or salts thereof in combination with a taxane selected from paclitaxel and docetaxel to a subject in need thereof. 3. A method of treating colon cancer comprising administering an effective amount of 5-((1-benzyl-1 H-indol- 3 -yl)methylene)-1-(3,4- dimethylphenyl)pyrimidine-2,4,6(1H,3H, 5H)-trione or salts thereof in combination with a taxane selected from paclitaxel and docetaxel to a subject in need thereof. 4. The method of claim 3 further comprising administering a third anti-cancer agent. 5. The method of claim 4 wherein the third anti-cancer agent is selected from gefitinib, erlotinib, cis-platin, 5-fluorouracil, gemcitabine, tegafur, raltitrexed, methotrexate, cytosine arabinoside, hydroxyurea, adriamycin, bleomycin, doxorubicin, daunomycin, epirubicin, idarubicin, mitomycin-C, dactinomycin, mithramycin, etoposide, teniposide, amsacrine, topotecan, camptothecin, bortezomib, anagrelide, tamoxifen, toremifene, raloxifene, droloxifene, iodoxyfene, fulvestrant, bicalutamide, flutamide, nilutamide, cyproterone, goserelin, leuprorelin, buserelin, megestrol, anastrozole, letrozole, vorazole, exemestane, finasteride, marimastat, trastuzumab, cetuximab, dasatinib, imatinib, bevacizumab, combretastatin, thalidomide, and lenalidomide. 6. The method of claim 1 further comprising administering a third anti-cancer agent. 7. The method of claim 6 wherein the third anti-cancer agent is selected from gefitinib, erlotinib, cis-platin, 5-fluorouracil, gemcitabine, tegafur, raltitrexed, methotrexate, cytosine arabinoside, hydroxyurea, adriamycin, bleomycin, doxorubicin, daunomycin, epirubicin, idarubicin, mitomycin-C, dactinomycin, mithramycin, etoposide, teniposide, amsacrine, topotecan, camptothecin, bortezomib, anagrelide, tamoxifen, toremifene, raloxifene, droloxifene, iodoxyfene, fulvestrant, bicalutamide, flutamide, nilutamide, cyproterone, goserelin, leuprorelin, buserelin, megestrol, anastrozole, letrozole, vorazole, exemestane, finasteride, marimastat, trastuzumab, cetuximab, dasatinib, imatinib, bevacizumab, combretastatin, thalidomide, and lenalidomide. 8. The method of claim 2 further comprising administering a third anti-cancer agent. 9. The method of claim 8 wherein the third anti-cancer agent is selected from gefitinib, erlotinib, cis-platin, 5-fluorouracil, gemcitabine, tegafur, raltitrexed, methotrexate, cytosine arabinoside, hydroxyurea, adriamycin, bleomycin, doxorubicin, daunomycin, epirubicin, idarubicin, mitomycin-C, dactinomycin, mithramycin, etoposide, teniposide, amsacrine, topotecan, camptothecin, bortezomib, anagrelide, tamoxifen, toremifene, raloxifene, droloxifene, iodoxyfene, fulvestrant, bicalutamide, flutamide, nilutamide, cyproterone, goserelin, leuprorelin, buserelin, megestrol, anastrozole, letrozole, vorazole, exemestane, finasteride, marimastat, trastuzumab, cetuximab, dasatinib, imatinib, bevacizumab, combretastatin, thalidomide, and lenalidomide.

Details for Patent 9,907,797

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	09/25/1998		2034-10-07
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	02/10/2017		2034-10-07
Eli Lilly And Company	ERBITUX	cetuximab	Injection	125084	02/12/2004		2034-10-07
Eli Lilly And Company	ERBITUX	cetuximab	Injection	125084	03/28/2007		2034-10-07