Claims for Patent: 9,821,057
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Summary for Patent: 9,821,057
Title: | Anti-IL-6 antibody for use in the treatment of cachexia |
Abstract: | The present invention is directed to therapeutic methods and compositions, especially subcutaneous and intravenous composition using antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat cachexia, fever, weakness and/or fatigue in a patient in need thereof. In preferred embodiments, the anti-IL-6 antibodies will be humanized and/or will be aglycosylated. Also, in preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level. In another preferred embodiment, the patient\'s survivability or quality of life will preferably be improved. |
Inventor(s): | Smith; Jeffrey T. L. (Bellevue, WA), Latham; John A. (Seattle, WA), Litton; Mark (Seattle, WA), Schatzman; Randall (Redmond, WA) |
Assignee: | ALDERBIO HOLDINGS LLC (Las Vegas, NV) |
Application Number: | 14/672,543 |
Patent Claims: | 1. A method for treating or inhibiting cachexia in a patient receiving chemotherapy, comprising administering to the patient an effective amount of an anti-IL-6 antibody or an IL-6 binding antibody fragment comprising the variable light (V.sub.L) chain CDR1 of SEQ ID NO:4, CDR2of SEQ ID NO:5 and CDR3 of SEQ ID NO:6, and the variable heavy (V.sub.H) chain CDR1 of SEQ ID NO:7, CDR2 of SEQ ID NO:8 or 120, and CDR3 of SEQ ID NO:9, wherein the patient has been diagnosed with cancer and the chemotherapy agent is selected from VEGF antagonists, EGFR antagonists, platins, taxols, irinotecan,5-fluorouracil, gemcitabine, leucovorin, steroids, cyclophosphamide, melphalan, vinca alkaloids, vinblastine, mustines, tyrosine kinase inhibitors, radiotherapy, sex hormone antagonists, selective androgen receptor modulators, selective estrogen receptor modulators, PDGF antagonists, TNF antagonists, IL-1 antagonists, interleukins, IL-12R antagonists, Toxin conjugated monoclonal antibodies, tumor antigen specific monoclonal antibodies, Erbitux.TM., Avastin.TM., Pertuzumab, anti-CD20 antibodies, Rituxan.RTM., ocrelizumab, ofatumumab, DXL625, Herceptin.RTM., or any combination thereof. |
Details for Patent 9,821,057
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Novartis Pharmaceuticals Corporation | ARZERRA | ofatumumab | Injection | 125326 | 10/26/2009 | ⤷ Try a Trial | 2029-11-24 |
Novartis Pharmaceuticals Corporation | ARZERRA | ofatumumab | Injection | 125326 | 04/01/2011 | ⤷ Try a Trial | 2029-11-24 |
Novartis Pharmaceuticals Corporation | KESIMPTA | ofatumumab | Injection | 125326 | 08/20/2020 | ⤷ Try a Trial | 2029-11-24 |
Genentech, Inc. | PERJETA | pertuzumab | Injection | 125409 | 06/08/2012 | ⤷ Try a Trial | 2029-11-24 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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