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Last Updated: March 28, 2024

Claims for Patent: 9,814,767


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Summary for Patent: 9,814,767
Title:Methods and materials for generating CD8+ T cells having the ability to recognize cancer cells expressing a HER2/neu polypeptide
Abstract: This document provides methods and materials for generating CD8.sup.+ T cells having the ability to recognize cancer cells expressing a HER2/neu polypeptide. For example, methods and materials for using a polypeptide consisting of an SLAFLPESFD amino acid sequence in vivo or in vitro to generate CD8.sup.+ T cells having the ability to recognize and lyse cancer cells expressing a HER2/neu polypeptide are provided.
Inventor(s): Knutson; Keith L. (Fort Pierce, FL), Henle; Andrea M. (Cambridge, MA)
Assignee: Mayo Foundation for Medical Education and Research (Rochester, MN)
Application Number:14/379,150
Patent Claims:1. A composition comprising a polypeptide, wherein the sequence of said polypeptide consists of the amino acid sequence set forth in SEQ ID NO:1, wherein said polypeptide is immunogenic, and wherein said composition comprises an adjuvant and an agent selected from the group consisting of IL-2, GM-CSF, and rintatolimod.

2. The composition of claim 1, wherein said adjuvant is an oil and water mixture.

3. The composition of claim 1, wherein said adjuvant is Montanide ISA-51.

4. The composition of claim 1, wherein said agent is IL-2.

5. A method for increasing the number of CD8.sup.+ T cells having the ability to kill breast cancer cells expressing a HER2/neu polypeptide, wherein said method comprises contacting a population of CD8.sup.+ T cells with a polypeptide and an agent selected from the group consisting of IL-2, GM-CSF, and rintatolimod, wherein the sequence of said polypeptide consists of the amino acid sequence set forth in SEQ ID NO:1.

6. The method of claim 5, wherein said contacting step occurs in an ex vivo manner.

7. The method of claim 5, wherein said contacting step occurs in an in vivo manner.

8. A method for increasing, within a human, the number of CD8.sup.+ T cells having the ability to kill breast cancer cells expressing a HER2/neu polypeptide, wherein said method comprises administering a composition to said human, wherein said composition comprises a polypeptide and an agent selected from the group consisting of IL-2, GM-CSF, and rintatolimod, wherein the sequence of said polypeptide consists of the amino acid sequence set forth in SEQ ID NO:1.

9. The method of claim 8, wherein said human contains breast cancer cells expressing said HER2/neu polypeptide.

10. The method of claim 8, wherein said composition comprises an adjuvant.

11. The method of claim 10, wherein said adjuvant is an oil and water mixture.

12. The method of claim 10, wherein said adjuvant is Montanide ISA-51.

13. The method of claim 8, wherein said agent is IL-2.

14. The method of claim 8, wherein said agent is GM-CSF.

15. The method of claim 8, wherein said method further comprises administering trastuzumab to said human.

Details for Patent 9,814,767

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 09/25/1998 ⤷  Try a Trial 2032-02-17
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 02/10/2017 ⤷  Try a Trial 2032-02-17
Genentech, Inc. HERCEPTIN HYLECTA trastuzumab and hyaluronidase-oysk Injection 761106 02/28/2019 ⤷  Try a Trial 2032-02-17
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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