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Last Updated: April 18, 2024

Claims for Patent: 9,788,950

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Summary for Patent: 9,788,950

Title:	Cohesive bone composition
Abstract:	A cohesive bone composition is made from a moldable bone composition intermixed with a bone gel composition. The cohesive bone composition is made from human cadaver bone. A fluid can be added, the fluid may also be laden with cells.
Inventor(s):	Weston; Wendy W. (Miami, FL), Maldonado; Edgar S. (Miami, FL), Gonzales; Silvia Daniela (Miami, FL), Namin; Shabnam (Miami, FL)
Assignee:	Vivex Biomedical, Inc. (Atlanta, GA)
Application Number:	15/136,534
Patent Claims:	1. A cohesive bone composition comprises: a moldable bone composition mixed with a bone gel composition; the moldable bone composition consisting of a mixture of cortical bone and cancellous bone, the cortical bone is formed in three portions, a mineralized shaving portion and a demineralized shaving portion and a mineralized powder portion, the cancellous bone is formed in a mineralized crushed cancellous portion, the portions are freeze-dried and mixed together to form a freeze-dried bone composition and when subjected to a fluid, the composition can be molded to a desired shape; the bone gel composition consisting of cortical bone consists of cortical bone made from cut pieces freeze dried then ground into particles and demineralized then freeze-dried, wherein a volume of the particles is placed in a solution of sterile water to create a mixture, the water volume being twice the volume of the particles, the mixture is autoclaved under heat and pressure to form a gelatin, the resulting bone gel is placed in jars for later use; and wherein a volume of moldable bone composition is mixed with a volume of the bone gel composition and wetted with a fluid to form the cohesive bone composition. 2. The cohesive bone composition of claim 1 wherein the moldable bone composition crushed cancellous bone is made from freeze-dried morselized cancellous ground to a size of 1000 to 1700 microns. 3. The cohesive bone composition of claim 1 wherein the moldable bone composition cortical bone powder is ground to 300 microns or less. 4. The cohesive bone composition of claim 1 wherein the moldable bone composition cortical shavings are long thin strips cut from cortical bone plates having a length of greater than 5 cm. 5. The cohesive bone composition of claim 4 wherein the moldable bone composition cortical shavings are strands having a length greater than 3 mm. 6. The cohesive bone composition of claim 1 wherein the moldable bone composition mixture has a percentage of demineralized cortical bone shaving portion by weight in the range of 15 to 25%. 7. The cohesive bone composition of claim 1 wherein the moldable bone composition mixture has a percentage of mineralized dry cortical bone shaving by volume in the range of 70 to 50%. 8. The cohesive bone composition of claim 1 wherein the moldable bone composition mixture has a percentage of mineralized dry cortical bone powder by volume in the range of 5 to 15%. 9. The cohesive bone composition of claim 1 wherein the moldable bone composition mixture has a percentage of dry crushed cancellous by volume in the range of 5 to 15%. 10. The cohesive bone composition of claim 1 wherein the moldable bone composition has a percentage of demineralized cortical bone shaving by weight of 20%. 11. The cohesive bone composition of claim 1 wherein the moldable bone composition has a percentage of dry mineralized cortical bone shaving by volume of 60%. 12. The cohesive bone composition of claim 1 wherein the moldable bone composition has a percentage of dry cortical bone powder by volume of 10%. 13. The cohesive bone composition of claim 1 wherein the moldable bone composition has a percentage of dry crushed cancellous by volume of 10%. 14. The cohesive bone composition of claim 1 wherein the moldable bone composition has a percentage of 20% demineralized cortical bone shaving, 60% dry mineralized cortical bone shaving, 10% dry cortical bone powder and 10% dry crushed cancellous. 15. The cohesive bone composition of claim 1 wherein the moldable bone composition formed as a freeze-dried material packaged in jars wherein the packaged mixture is stored at room temperature or frozen. 16. The cohesive bone composition of claim 1 wherein the bone gel composition cortical bone has the cut pieces having a width, a length and a thickness in the range of 1 to 4 mm. 17. The cohesive bone composition of claim 16 wherein the bone gel composition cortical bone pieces are ground to a particle size up to 125 microns. 18. The cohesive bone composition of claim 1 wherein the bone gel composition when placed in jars is then frozen.

Details for Patent 9,788,950

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	ZOSTAVAX	zoster vaccine live	For Injection	125123	05/25/2006	⤷ Try a Trial	2039-09-22
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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