Get our Free Patent Expiration Newsletter

Serving hundreds of leading biopharmaceutical companies globally:

Harvard Business School
Healthtrust
UBS
Citi
Cantor Fitzgerald
Boehringer Ingelheim

Generated: August 18, 2019

DrugPatentWatch Database Preview

Claims for Patent: 9,732,055

  Try a free trial


See Plans and Pricing

« Back to Dashboard

Summary for Patent: 9,732,055
Title:Compositions and methods for cancer treatment
Abstract: The present invention relates to the composition and methods of use of Stat3 pathway inhibitors or cancer stem cell inhibitors in combination treatment of cancer.
Inventor(s): Li; Chiang Jia (Cambridge, MA), Mikule; Keith (Norwood, MA), Li; Youzhi (Westwood, MA)
Assignee: Boston Biomedical, Inc. (Cambridge, MA)
Application Number:12/677,516
Patent Claims:1. A method for treating cancer in a human subject in need thereof comprising administering a composition comprising a therapeutically effective amount of at least one first agent chosen from 2-acetylnaphtho[2,3-b]furan-4,9-dione and pharmaceutically acceptable solvates thereof, wherein said 2-acetylnaphtho[2,3-b]furan-4,9-dione is synthetic and a composition comprising a therapeutically effective amount of at least one second agent chosen from growth factor-targeting agents, kinase-targeting agents, angiogenesis inhibitors, DNA-damaging agents, antimitotic agents, and antimetabolite agents, wherein said cancer is head and neck cancer, brain cancer, breast cancer, lung cancer, liver cancer, pancreatic cancer, ovarian cancer, cervical cancer, uterine cancer, gastrointestinal cancer, kidney cancer, bladder cancer, vulval cancer, cancer of the peritoneum, prostate cancer, thyroid cancer, sarcomas, squamous cell cancer, melanoma, leukemia, lymphoma, or myeloma, wherein said cancer expresses activated STAT3.

2. The method of claim 1, wherein the cancer is metastatic.

3. The method of claim 1, wherein the cancer is refractory to chemotherapy or radiotherapy.

4. The method of claim 1, wherein the cancer is resistant to chemotherapy.

5. The method of claim 1, wherein the cancer has relapsed.

6. The method of claim 1, wherein said cancer is head and neck cancer.

7. The method of claim 6, wherein said head and neck cancer is salivary gland cancer.

8. The method of claim 1, wherein said cancer is brain cancer.

9. The method of claim 8, wherein said brain cancer is glioblastoma.

10. The method of claim 1, wherein said cancer is breast cancer.

11. The method of claim 1, wherein said cancer is lung cancer.

12. The method of claim 11, wherein said lung cancer is small-cell lung cancer, non-small-cell lung cancer, adenocarcinoma of the lung, and/or squamous carcinoma of the lung.

13. The method of claim 1, wherein said cancer is liver cancer.

14. The method of claim 13, wherein said liver cancer is a hepatocellular carcinoma.

15. The method of claim 1, wherein said cancer is pancreatic cancer.

16. The method of claim 1, wherein said cancer is ovarian cancer.

17. The method of claim 1, wherein said cancer is uterine cancer.

18. The method of claim 1, wherein said uterine cancer is endometrial cancer.

19. The method of claim 1, wherein said cancer is cervical cancer.

20. The method of claim 1, wherein said cancer is gastrointestinal cancer.

21. The method of claim 20, wherein said gastrointestinal cancer is esophageal cancer, gastroesophageal junction cancer, gastric cancer, colon cancer, and/or colorectal cancer.

22. The method of claim 20, wherein said gastrointestinal cancer is esophageal and/or gastroesophageal junction cancer.

23. The method of claim 20, wherein said gastrointestinal cancer is gastric cancer.

24. The method of claim 20, wherein said gastrointestinal cancer is colon cancer.

25. The method of claim 20, wherein said gastrointestinal cancer is colorectal cancer.

26. The method of claim 1, wherein said cancer is cancer of the peritoneum.

27. The method of claim 1, wherein said cancer is kidney cancer.

28. The method of claim 27, wherein said kidney cancer is renal cell carcinoma.

29. The method of claim 1, wherein said cancer is bladder cancer.

30. The method of claim 1, wherein said cancer is vulval cancer.

31. The method of claim 1, wherein said cancer is prostate cancer.

32. The method of claim 1, wherein said cancer is thyroid cancer.

33. The method of claim 1, wherein said cancer is a sarcoma.

34. The method of claim 1, wherein said cancer is squamous cell cancer.

35. The method of claim 1, wherein said cancer is melanoma.

36. The method of claim 1, wherein said cancer is leukemia.

37. The method of claim 1, wherein said cancer is lymphoma.

38. The method of claim 1, wherein said cancer is myeloma.

39. The method of claim 38, wherein said myeloma is multiple myeloma.

40. The method of claim 1, wherein said at least one second agent is chosen from bevacizurnab, bortezomib, capecitabine, cetuximab, fluorouracil, imatinib, irinotecan, leucovorin, oxaliplatin, panitumumab, pemetrexed, temozolomide, cisplatin, paclitaxel, erlotinib, sunitinib, lapatinib, sorafenib, carboplatin, doxorubicin, docetaxel, gemcitabine, and etoposide.

41. The method of claim 1, wherein said at least one second agent is chosen from growth factor-targeting agents.

42. The method of claim 1, wherein said at least one second agent is chosen from Epidermal Growth Factor Receptor-targeting agents and Vascular Endothelial Growth Factor Receptor-targeting agents.

43. The method of claim 1, wherein said at least one second agent is chosen from gefitinib, PD153035, cetuximab, bevacizumab, panitumumab, trastuzumab, and anti-c-Met antibodies.

44. The method of claim 1, wherein said at least one second agent is chosen from kinase-targeting agents.

45. The method of claim 1, wherein said at least one second agent is chosen from kinase inhibitors.

46. The method of claim 1, wherein said at least one second agent is chosen from tyrosine kinase inhibitors.

47. The method of claim 1, wherein said at least one second agent is chosen from erlotinib, sunitinib, lapatinib, sorafenib, vandetanib, axitinib, bosutinib, cedivanib, dasatinib, gefitinib, imatinib, lestaurtinib, and ARQ197.

48. The method of claim 1, wherein said at least one second agent is chosen from gefitinib, ZD6474, EMD-72000, pariitumab, ICR-62, CI-1033, lapatinib, AEE788, EKB-569, EXEL 7647/EXEL 0999, erlotinib, imatinib, sorafinib, sunitinib, dasatinib, vandetinib, temsirolimus, PTK787, pazopanib, AZD2171, everolimus, seliciclib, AMG 706, axitinib, PD0325901, PKC-412, CEP701, XL880, bosutinib, BIBF1120, BIBF1120, nilotinib, AZD6244, HKI-272, MS-275, BI2536, GX15-070, AZD0530, enzastaurin, MLN-518, and ARQ197.

49. The method of claim 1, wherein said at least one second agent is chosen from erlotinib, lapatinib, and gefitinib.

50. The method of claim 1, wherein said at least one second agent is chosen from angiogenesis inhibitors.

51. The method of claim 1, wherein said at least one second agent is chosen from CM101, IFN-.alpha., IL-12, platelet factor-4, suramin, SU5416, thrombospondin, VEGFR antagonists, angiostatic steroids plus heparin, Cartilage-Derived Angiogenesis Inhibitory Factor, matrix metalloproteinase inhibitors, batimastat, marimastat, angiostatin, endostatin, 2-methoxyestradiol, tecogalan, thrombospondin, .alpha.V.beta.3 inhibitors, linomide, and ADH-1.

52. The method of claim 1, wherein said at least one second agent is chosen from DNA-damaging agents.

53. The method of claim 1, wherein said at least one second agent is chosen from alkylating agents, topoisomerase inhibitors, and DNA intercalators.

54. The method of claim 1, wherein said at least one second agent is chosen from alkylating agents.

55. The method of claim 1, wherein said at least one second agent is chosen from chlorambucil, cyclophosphamide, ifosfamide, mechlorethamine, melphalan, uracil mustard, thiotepa, busulfan, carmustine, lomustine, streptozocin, carboplatin, cisplatin, satraplatin, oxaliplatin, altretamine, ET-743, XL119, dacarbazine, chlormethine, bendamustine, trofosfamide, uramustine, fotemustine, nimustine, prednimustine, ranimustine, semustine, nedaplatin, triplatin tetranitrate, mannosulfan, treosulfan, temozolomide, carboquone, triaziquone, triethylenemelamine, and procarbazin.

56. The method of claim 1, wherein said at least one second agent is chosen from topoisomerase inhibitors.

57. The method of claim 1, wherein said at least one second agent is chosen from doxorubicin, daunorubicin, epirubicin, idarubicin, anthracenedione, mitoxantrone, mitomycin C, bleomycin, dactinomycin, plicatomycin, irinotecan, camptothecin, rubitecan, belotecan, etoposide, teniposide, and topotecan.

58. The method of claim 1, wherein said at least one second agent is chosen from DNA intercalators.

59. The method of claim 1, wherein said at least one second agent is chosen from proflavine, doxorubicin, daunorubicin, dactinomycin, and thalidomide.

60. The method of claim 1, wherein said at least one second agent is chosen from antimitotic agents.

61. The method of claim 1, wherein said at least one second agent is chosen from paclitaxel, taxol, docetaxel, BMS-275183, xyotax, tocosal, vinorlebine, vincristine, vinblastine, vindesine, vinzolidine, etoposide, teniposide, ixabepilone, larotaxel, ortataxel, tesetaxel, and ispinesib.

62. The method of claim 1, wherein said at least one second agent is chosen from antimetabolite agents.

63. The method of claim 1, wherein said at least one second agent is chosen from fluorouracil, floxuridine, methotrexate, xeloda, arranon, leucovorin, hydroxyurea, thioguanine, mercaptopurine, cytarabine, pentostatin, fludarabine phosphate, cladribine, asparaginase, gemcitabine, pemetrexed, bortezomib, aminopterin, raltitrexed, clofarabine, enocitabine, sapacitabine, and azacitidine.

64. The method of claim 1, wherein said at least one second agent is chosen from fluorouracil, methotrexate, capecitabine, leucovorin, gemcitabine, pemetrexed, and bortezomib.

65. The method of claim 1, wherein said at least one second agent is chosen from carboplatin, doxorubicin, gemcitabine, docetaxel, and etoposide.

66. The method of claim 1, wherein said at least one second agent is chosen from doxorubicin, irinotecan, and etoposide.

67. The method of claim 1, wherein said at least one second agent is chosen from carboplatin, cisplatin, satraplatin, oxaliplatin, nedaplatin, triplatin tetranitrate, temozolomide, or procarbazin, or any combination thereof.

68. The method of claim 1, wherein the second agent is chosen from paclitaxel, taxol, docetaxel, xyotax, tocosal, vinorlebine, vincristine, vinblastine, vindesine, vinzolidine, teniposide, ixabepilone, larotaxel, ortataxel, and tesetaxel.

69. The method of claim 1, wherein said at least one second agent is chosen from paclitaxel, taxol, docetaxel, xyotax, larotaxel, ortataxel, and tesetaxel.

70. The method of claim 1, wherein said at least one second agent is paclitaxel.

71. The method of claim 1, wherein said at least one second agent is temozolomide.

72. The method of claim 1, wherein said at least one second agent is doxorubicin.

73. The method of claim 1, comprising administering said composition comprising a therapeutically effective amount of at least one first agent and said composition comprising a therapeutically effective amount of at least one second agent to a human subject with cancer, wherein said cancer is head and neck cancer, brain cancer, breast cancer, lung cancer, liver cancer, pancreatic cancer, ovarian cancer, cervical cancer, uterine cancer, gastrointestinal cancer, kidney cancer, bladder cancer, vulval cancer, cancer of the peritoneum, prostate cancer, thyroid cancer, sarcomas, squamous cell cancer, melanoma, leukemia, lymphoma, or myeloma.

74. The method of claim 1, wherein said composition comprising a therapeutically effective amount of at least one first agent is chosen from compositions consisting of at least one first agent.

75. The method of claim 1, wherein said composition comprising a therapeutically effective amount of at least one first agent further comprises at least one pharmaceutically-acceptable excipient, carrier, or diluent.

76. The method of claim 75, where said at least one pharmaceutically-acceptable excipient, carrier, or diluent is chosen from Gelucire.

77. The method of claim 1, wherein said composition comprising a therapeutically effective amount of at least one second agent is chosen from compositions consisting of at least one second agent.

78. The method of claim 1, wherein said composition comprising a therapeutically effective amount of at least one second agent further comprises at least one pharmaceutically-acceptable excipient, carrier, or diluent.

79. The method of claim 78, where said at least one pharmaceutically-acceptable excipient, carrier, or diluent is chosen from Gelucire.

80. The method of claim 1, wherein said composition comprising a therapeutically effective amount of at least one first agent is formulated for oral administration.

81. The method of claim 1, wherein said composition comprising a therapeutically effective amount of at least one second agent is formulated for oral administration.

82. A method for treating cancer in a human subject in need thereof comprising administering to said subject a composition comprising a therapeutically effective amount of at least one first agent chosen from 2-acetylnaphtho[2,3-b]furan-4,9-dione and pharmaceutically acceptable solvates thereof, wherein said 2-acetylnaphtho[2,3-b]furan-4,9-dione is synthetic and a composition comprising a therapeutically effective amount of at least one second agent chosen from bevacizumab, bortezomib, capecitabine, cetuximab, fluorouracil, imatinib, irinotecan, leucovorin, oxaliplatin, panitumumab, pemetrexed, temozolomide, cisplatin, paclitaxel, erlotinib, sunitinib, lapatinib, sorafenib, carboplatin, doxorubicin, docetaxel, gemcitabine, and etoposide, wherein said cancer is head and neck cancer, brain cancer, breast cancer, lung cancer, liver cancer, pancreatic cancer, ovarian cancer, cervical cancer, uterine cancer, gastrointestinal cancer, kidney cancer, bladder cancer, vulval cancer, cancer of the peritoneum, prostate cancer, thyroid cancer, sarcoma, squamous cell cancer, melanoma, leukemia, lymphoma, or myeloma, wherein said cancer expresses activated STAT3.

83. The method of claim 82, wherein the cancer is metastatic, refractory to chemotherapy or radiotherapy, resistant to chemotherapy, or has relapsed.

84. A method for treating cancer in a human subject in need thereof comprising administering to said subject a composition comprising a therapeutically effective amount of at least one first agent chosen from 2-acetylnaphtho[2,3-b]furan-4,9-dione and pharmaceutically acceptable solvates thereof, wherein said 2-acetylnaphtho[2,3-b]furan-4,9-dione is synthetic and a composition comprising a therapeutically effective amount of at least one second agent chosen from carboplatin, etoposide, doxorubicin, docetaxel, and gemcitabine, wherein said cancer is head and neck cancer, brain cancer, breast cancer, lung cancer, liver cancer, pancreatic cancer, ovarian cancer, cervical cancer, uterine cancer, gastrointestinal cancer, kidney cancer, bladder cancer, vulval cancer, cancer of the peritoneum, prostate cancer, thyroid cancer, sarcoma, squamous cell cancer, melanoma, leukemia, lymphoma, or myeloma, wherein said cancer expresses activated STAT3.

85. The method of claim 84, wherein the cancer is metastatic, refractory to chemotherapy or radiotherapy, resistant to chemotherapy, or has relapsed.

86. A method for treating cancer in a human subject in need thereof comprising administering to said subject a composition comprising a therapeutically effective amount of at least one first agent chosen from 2-acetylnaphtho[2,3-b]furan-4,9-dione and pharmaceutically acceptable solvates thereof, wherein said 2-acetylnaphtho[2,3-b]furan-4,9-dione is synthetic and a composition comprising a therapeutically effective amount of paclitaxel, wherein said cancer is head and neck cancer, brain cancer, breast cancer, lung cancer, liver cancer, pancreatic cancer, ovarian cancer, uterine cancer, cervical cancer, gastrointestinal cancer, kidney cancer, bladder cancer, vulval cancer, cancer of the peritoneum, prostate cancer, thyroid cancer, sarcoma, squamous cell cancer, melanoma, leukemia, lymphoma, or myeloma, wherein said cancer expresses activated STAT3.

87. The method of claim 86, wherein said cancer is ovarian cancer, breast cancer, lung cancer, melanoma, gastrointestinal cancer, cervical cancer.

88. The method of claim 86, wherein said cancer is gastrointestinal cancer.

89. The method of claim 88, wherein said gastrointestinal cancer is esophageal cancer or gastroesophageal junction cancer.

90. The method of claim 88, wherein said cancer is colorectal cancer.

91. The method of claim 86, wherein the cancer is metastatic, refractory to chemotherapy or radiotherapy, resistant to chemotherapy, or has relapsed.

Summary for Patent: ➤ Sign Up

PCT Information
PCT FiledSeptember 10, 2008PCT Application Number:PCT/US2008/075906
PCT Publication Date:March 19, 2009PCT Publication Number:WO2009/036101

Details for Patent 9,732,055

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10 ➤ Sign Up Boston Biomedical, Inc. (Cambridge, MA) 2027-09-10 RX search
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25 ➤ Sign Up Boston Biomedical, Inc. (Cambridge, MA) 2027-09-10 RX Orphan search
Imclone ERBITUX cetuximab VIAL; INTRAVENOUS 125084 001 2004-06-18 ➤ Sign Up Boston Biomedical, Inc. (Cambridge, MA) 2027-09-10 RX Orphan search
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 001 2004-02-26 ➤ Sign Up Boston Biomedical, Inc. (Cambridge, MA) 2027-09-10 RX search
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 002 2004-02-26 ➤ Sign Up Boston Biomedical, Inc. (Cambridge, MA) 2027-09-10 RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source

Subscribe to access the full database, or try a Free Trial

International Patent Family for US Patent 9,732,055

Country Patent Number Publication Date
World Intellectual Property Organization (WIPO) 2009036059 Jul 02, 2009
World Intellectual Property Organization (WIPO) 2009036059 Mar 19, 2009
World Intellectual Property Organization (WIPO) 2009036099 Mar 19, 2009
World Intellectual Property Organization (WIPO) 2009036101 Mar 19, 2009
United States of America 2010310503 Dec 09, 2010
Country Patent Number Publication Date

Subscribe to access the full database, or try a Free Trial

Make Better Decisions: Try a trial or see plans & pricing

Serving hundreds of leading biopharmaceutical companies globally:

Covington
McKesson
Boehringer Ingelheim
QuintilesIMS
McKinsey
Merck

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.