Claims for Patent: 9,717,742

Summary for Patent: 9,717,742

Title:	Oxysterol analogue OXY133 induces osteogenesis and hedgehog signaling and inhibits adipogenesis
Abstract:	This invention relates, e.g., to a synthetic compound, Oxy133, having the structure [Formula I] or a bioactive or pharmaceutical composition comprising Oxy133 and a pharmaceutically acceptable carrier. Methods are also disclosed for using the compound or bioactive or pharmaceutical composition to treat a variety of disorders, including e.g. bone disorders, obesity, cardiovascular disorders, and neurological disorders. ##STR00001##
Inventor(s):	Parhami; Farhad (Los Angeles, CA), Jung; Michael E. (Los Angeles, CA), Stappenbeck; Frank (San Diego, CA)
Assignee:	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, CA)
Application Number:	14/399,121
Patent Claims:	1. A compound having the structure: ##STR00006## or a pharmaceutically acceptable salt or solvate thereof. 2. A composition, comprising a pharmaceutically acceptable carrier and a compound having the structure: ##STR00007## or a pharmaceutically acceptable salt or solvate thereof. 3. The composition of claim 2, further comprising at least one additional agent, selected from the group consisting of parathyroid hormone, sodium fluoride, insulin-like growth factor I (ILGF-I), insulin-like growth factor II (ILGF-II), transforming growth factor beta (TGF-.beta.), a cytochrome P450 inhibitor, an osteogenic prostanoid, BMP 2, BMP 4, BMP 7, BMP 14, and combinations thereof. 4. A method for treating a subject having a bone disorder, osteoporosis, or a bone fracture, comprising administering to the subject an effective amount of the composition of claim 2. 5. The method of claim 4, comprising administering to the subject the composition at a therapeutically effective dose in an effective dosage form at a selected interval to increase bone mass. 6. The method of claim 4, comprising administering to the subject the composition at a therapeutically effective dose in an effective dosage form at a selected interval to ameliorate the symptoms of osteoporosis. 7. A method for treating a subject in need of an increase in osteomorphogenesis and/or osteoproliferation, comprising administering to the subject an effective amount of the composition of claim 2. 8. A method for treating a subject to induce bone formation, comprising administering the composition of claim 2 in an effective dosage form at a selected interval to increase bone mass. 9. The method of claim 4, wherein the composition is administered locally to a cell, tissue or organ in the subject. 10. An implant for use in a human or animal body comprising a substrate having a surface, wherein the surface or the insides of the implant comprises the composition of claim 2 in an amount sufficient to induce bone formation in the surrounding bone tissue. 11. The implant of claim 10, wherein the substrate is formed into the shape of a pin, screw, plate, or prosthetic joint.

Details for Patent 9,717,742

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015		2032-05-07