You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: April 25, 2024

Claims for Patent: 9,713,629

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 9,713,629

Title:	Compositions and methods for treating and preventing tissue injury and disease
Abstract:	The present invention provides novel compositions comprising multipotent cells or microvascular tissue, wherein the cells or tissue has been sterilized and/or treated to inactivated viruses, and related methods of using these compositions to treat or prevent tissue injury or disease in an allogeneic subject.
Inventor(s):	Peterson; Dale R. (Carlsbad, CA), Mattern; Ralph-Heiko (Ramona, CA), Wilson-Wirth; Corey (San Diego, CA), Ohashi; Kevin L. (Jamaica Plain, MA)
Assignee:	MicroVascular Tissues, Inc. (Beverly, MA)
Application Number:	14/429,511
Patent Claims:	1. A method of preparing a composition comprising processed microvascular tissue, wherein the composition has angiogenic or anti-inflammatory activity, the method comprising: (a) dissociating a microvascular tissue sample obtained from a donor mammal to produce a composition comprising dissociated microvascular tissue; (b) removing one or more tissue components from the composition produced according to (a); (c) optionally drying, lyophilizing, or cryopreserving the composition following (b) or (d); and (d) sterilizing the composition following (b) or (c) and/or inactivating virus present in the composition following (b) or (c); wherein the composition resulting from (c) or (d) retains measurable angiogenic or anti-inflammatory activity; wherein: (i) the cells or tissue are not cultured; (ii) the method further comprises filtering the composition; (iii) the dissociation of (a) comprises contacting the tissue sample with one or more proteases; and (iv) the dissociation of (a) or the removing of (b) comprises ultrasonic agitation, centrifugation, filtration, or use of a density gradient; and further wherein (v) the one or more proteases does not comprise collagenase; (vi) the one or more proteases comprises or consists of: collagenase type 1 and either dispase or thermolysin; or MMP 2, MMP 14 and either dispase or thermolysin; or (vii) the microvascular tissue is adipose-derived tissue, and the ultrasonic agitation, centrifugation, filtration or use of a density gradient removes adipocytes from the composition produced according to (a).

Details for Patent 9,713,629

Glossary

Subscribe to access the full database, or Try a Trial
Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965	⤷ Try a Trial	2032-09-19
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.