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Last Updated: January 26, 2022

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Claims for Patent: 9,682,147

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Summary for Patent: 9,682,147
Title:Self-preserved oil dispersions comprising boric acid
Abstract: The present invention relates to a self-preserved oil dispersion. Especially, the present invention relates to a self-preserved oil dispersion including a dispersed oil phase, an aqueous phase and at least one surfactant, wherein said oil dispersion comprises boric acid in an amount ranging from 0.005% to 0.075% in weight of the total weight of the oil dispersion, said amount of boric acid being a preservative effective amount so that the oil dispersion has a preservative activity.
Inventor(s): Garrigue; Jean-Sebastien (Verrieres le Buisson, FR), Lallemand; Frederic (Fresnes, FR), Philips; Betty (Antony, FR)
Assignee: SANTEN SAS (Evry, FR)
Application Number:14/380,655
Patent Claims:1. A cationic oil dispersion comprising a dispersed oil phase, an aqueous phase, at least one cationic surfactant, and boric acid or a salt thereof, the boric acid present in an amount ranging from 0.005% to 0.075% by weight of the total weight of the cationic oil dispersion, wherein said amount of boric acid is effective to self-preserve the cationic oil dispersion and wherein the cationic oil dispersion does not contain conventional preservative agents and does not contain sorbic acid.

2. The cationic oil dispersion of claim 1, having sufficient preservative activity to comply with USP and/or Ph. Eur. preservative efficacy requirements.

3. The cationic oil dispersion of claim 1, wherein the dispersion is an oil-in-water emulsion.

4. The cationic oil dispersion of claim 1, wherein the amount of boric acid ranges from 0.008 to 0.05% w/w.

5. The cationic oil dispersion of claim 1, wherein the amount of boric acid ranges from 0.01 to 0.05% w/w.

6. The cationic oil dispersion of claim 1, wherein the amount of boric acid ranges from 0.01 to 0.02% w/w.

7. The cationic oil dispersion of claim 1, wherein the boric acid is sodium borate, sodium metaborate, calcium borate, borax, tricopper diborate, trioleyl borate, lithium borate, tris(trimethylsilyl) borate, ethyl borate, potassium tetrafluoroborate, disodium dihydrogen borate, manganese borate, oleyl borate, tripentyl borate, tributyl borate, trimethyl borate, tridodecyl borate, triazanium borate, or a combination of any of the foregoing.

8. The cationic oil dispersion of claim 1, wherein the oil phase comprises an oil selected from mineral oil, medium chain triglycerides), triglyceride oils, vegetable oils, corn oil, olive oil, soybean oil, sesame oil, cotton seed oil, sweet almond oil, fatty acid, isopropyl myristate, oily fatty alcohols, esters of sorbitol and fatty acids, oily sucrose esters, and a combination of any of the foregoing.

9. The cationic oil dispersion of claim 1, wherein the cationic surfactant is selected from cetalkonium chloride (CKC), benzethonium chloride, cetrimide, cationic lipids, oleylamine, stearylamine, DOTAP (N-[1-(2,3-dioleoyloxy) propyl]-N,N,N trimethylammonium) chloride, DOPE (dioleoyl phosphatidylethanolamine), poly(ethylenimine) (PEI), poly-L-lysine (PLL), and a combination of any of the foregoing.

10. The cationic oil dispersion of claim 1, comprising a non-ionic surfactant.

11. The cationic oil dispersion of claim 10, wherein the non-ionic surfactant is selected from tyloxapol, poloxamer, polysorbate, solutol, polyoxyethylene fatty acid esters, polyoxyethylene castor oil derivatives, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene stearates, sodium lauryl sulfate, sorbitan esters, vitamin E derivatives, and a combination of any of the foregoing.

12. The cationic oil dispersion of claim 1, further comprising a therapeutically active agent.

13. The cationic oil dispersion of claim 12, wherein the therapeutically active agent is selected from antiallergenics; synthetic glucocorticoids and mineralocorticoids; hormones derived from progesterone, estrogens, or androgenic hormones; anti-inflammatories; non-steroidal anti-inflammatories; immunological drugs; insulin, calcitonin, parathyroid hormone and peptide and vasopressin hypothalamus releasing factor; beta adrenergic blockers; prostaglandins; growth factors; anti-angiogenic compounds; antibodies, antibody fragments, oligoaptamers, aptamers, gene fragments, oligonucleotides, plasmids, ribozymes, small interference RNA, nucleic acid fragments, peptides, antisense sequences; immunomodulators; secretagogues; mucin secretagogues; antithrombolytic and vasodilator agents; androgen mimetics, flaxseed oil supplements, agonists of adenosine A3 receptor, squalene; antioxidants; inhibitors of carbonic anhydrase; sympathomimetics; parasympathomimetics; cholinesterase inhibitors; antivirals; antibiotics; antifungals; antibacterials; derivatives of any of the foregoing; prodrugs of any of the foregoing; precursors of any of the foregoing; acceptable salts of any of the foregoing; and a combination of any of the foregoing.

14. The cationic oil dispersion of claim 12, wherein the therapeutically active agent is selected from cortisone, hydrocortisone, hydrocortisone acetate, dexamethasone, dexamethasone 21-phosphate, fluorocinolone, medrysone, prednisone, methylprednisone, prednisolone acetate, fluoromethalone, triamcinolone, betamethasone, loteprednol, flumethasone, mometasone, danazol, beclomethasone, difluprednate and triamcinolone acetonide and their derivatives; latanoprost, bimatoprost, tafluprost or travoprost; natural or synthetic cyclosporines, endoxan, sirolimus, tacrolimus, thalidomide, and tamoxifene.

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