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Last Updated: March 28, 2024

Claims for Patent: 9,682,144


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Summary for Patent: 9,682,144
Title:Composition comprising inhibitors of IRS-1 and of VEGF
Abstract: The present invention relates to a composition or kit of parts comprising an inhibitor of IRS-1 and an inhibitor of the VEGF pathway and to the use thereof for treating an angiogenic disease.
Inventor(s): Thorin; Eric (Montreal, CA), Al-Mahmood; Salman (Paris, FR), Colin; Sylvie (Paris, FR), Ferry; Antoine (Paris, FR), Viaud; Eric (Lausanne, CH)
Assignee: GENE SIGNAL INTERNATIONAL, SA (CH)
Application Number:14/130,246
Patent Claims:1. A method for treating an angiogenic disease comprising administering a synergistic therapeutically effective amount of an inhibitor of insulin receptor substrate-1 (IRS-1) expression and an inhibitor of vascular endothelial growth factor (VEGF) pathway, wherein the inhibitor of IRS-1 is an IRS-1 antisense oligonucleotide consisting of a sequence SEQ ID NO: 2, or any function conservative sequence of SEQ ID NO: 2 selected from the group consisting of SEQ ID NO: 3 to 21 and wherein the inhibitor of the VEGF pathway is the anti-VEGF antibody, ranibizumab, wherein: the synergistic therapeutically effective amount of the inhibitor of insulin receptor substrate-1 (IRS-1) is such that an amount of 0.5 .mu.g may be administered to a subject in need thereof; and the synergistic therapeutically effective amount of an inhibitor of the anti-VEGF antibody, ranibizumab is such that an amount of 25 ng may be administered to a subject in need thereof.

2. The method of claim 1, wherein the angiogenic disease is an ocular angiogenic disease.

Details for Patent 9,682,144

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 06/30/2006 ⤷  Try a Trial 2031-06-30
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 08/10/2012 ⤷  Try a Trial 2031-06-30
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 10/13/2016 ⤷  Try a Trial 2031-06-30
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 03/20/2018 ⤷  Try a Trial 2031-06-30
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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