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Last Updated: March 29, 2024

Claims for Patent: 9,675,737


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Summary for Patent: 9,675,737
Title:Methods of providing antioxidants to a drug containing product
Abstract: A method of providing an antioxidant to a medical device and a kit are described.
Inventor(s): Ding; Ni (San Jose, CA)
Assignee: ABBOTT CARDIOVASCULAR SYSTEMS INC. (Santa Clara, CA)
Application Number:12/851,420
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 9,675,737
Patent Claims:1. A kit, comprising: a pouch; a medical device with a drug in the pouch; a porous or permeable container in the pouch; and an antioxidant in the porous or permeable container such that the medical device with the drug is placed outside of the porous or permeable container; wherein the antioxidant is a volatile antioxidant and evaporates and fills the space of the pouch.

2. The kit according to claim 1, wherein the antioxidant comprises butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA) or a combination thereof.

3. The kit according to claim 1, wherein the antioxidant is of a type to sublime to form a gas that permeates out from the container.

4. The kit according to claim 1, wherein the antioxidant of claim 1 is a first antioxidant; and wherein the medical device or the drug comprises a second antioxidant, the second antioxidant being the same as or different than the first antioxidant, such that the first antioxidant is adapted to be added to the medical device or the drug subsequent to a loss of the second antioxidant from the medical device or the drug during the life of the medical device or the drug in the pouch.

5. The kit according to claim 1, wherein the medical device comprises a stent.

6. The kit according to claim 1, wherein the medical device comprises a coated stent.

7. The kit according to claim 1, wherein the coating comprises the drug.

8. The kit according to claim 7, wherein the drug is selected from the group consisting of paclitaxel, docetaxel, estradiol, nitric oxide donors, super oxide dismutases, super oxide dismutases mimics, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), tacrolimus, dexamethasone, rapamycin, rapamycin derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (everolimus), pimecrolimus, 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, 40-O-tetrazole-rapamycin, 40-epi-(N1-tetrazolyl)-rapamycin (ABT-578), imatinib mesylate, midostaurin, clobetasol, bioactive RGD, CD-34 antibody, abciximab (REOPRO), progenitor cell capturing antibody, and prodrugs and combinations thereof.

9. The kit of claim 6, wherein the coated stent is crimped on a delivery catheter or a balloon catheter.

10. The kit according to claim 1, wherein the medical device comprises a coating which comprises a biocompatible polymer.

11. The kit according to claim 10, wherein the biocompatible polymer is selected from the group consisting of poly(ester amide), ethylene vinyl alcohol copolymer, poly(D,L-lactide) (PDLLA), poly(D,L-lactic acid-co-glycolic acid) (PDLLGA), polyglycolic acid (PGA), polyhydroxyalkanoate (PHA), poly(3-hydroxybutyrate) (PHB), poly(3-hydroxybutyrate-co-3-hydroxyvalerate), poly(3-hydroxyvalerate), poly(3-hydroxyhexanoate), poly(4-hydroxybutyrate), poly(4-hydroxyvalerate), poly(4-hydroxyhexanoate), poly(D,L-lactide), poly(L-lactide), polycaprolactone (PCL), polydioxanone, polyorthoester, polyanhydride, poly(glycolic acid-co-trimethylene carbonate), and a combination thereof.

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