Claims for Patent: 9,598,734

Summary for Patent: 9,598,734

Title:	Methods and devices for predicting treatment efficacy
Abstract:	The present invention features methods, devices, and kits for predicting the sensitivity of a patient to a compound or medical treatment. The invention also features methods for identifying biomarkers, the expression of which correlates to treatment sensitivity or resistance within a patient population or subpopulation.
Inventor(s):	Knudsen; Steen (Birkroed, DK)
Assignee:	Medical Prognosis Institute A/S (Horsholm, DK)
Application Number:	13/695,102
Patent Claims:	1. A method of predicting the responsiveness of a patient diagnosed with brain cancer, lung cancer, or lymphoma to at least one treatment for cancer comprising: i) contacting a tumor sample comprising one or more nucleic acid molecules from said patient with a device comprising at least one first single-stranded nucleic acid molecule having at least 85% sequence identity to a nucleic acid sequence that is complementary or identical to at least 15 consecutive nucleotides of hsa-miR-766_st (SEQ ID NO: 1); and ii) measuring hybridization between said one or more nucleic acid molecules from said patient and said at least one first single-stranded nucleic acid molecule of said device to detect a level of expression of hsa-miR-766_st; wherein said patient is predicted to be responsive to said least one treatment for cancer if the level of expression of hsa-miR-766_st is substantially similar to the level of expression of hsa-miR-766_st in a cell or tissue known to be responsive to said at least one treatment for cancer. 2. The method of claim 1, wherein said device further comprises: i) at least one second single-stranded nucleic acid molecule having at least 85% sequence identity to a target nucleic acid molecule having a sequence that is complementary or identical to at least 15 consecutive nucleotides of at least one biomarker of sensitivity selected from the group consisting of SEQ ID NOs: 2-534, or ii) at least one second single-stranded nucleic acid molecule having at least 85% sequence identity to a target nucleic acid molecule having a sequence that is complementary or identical to at least 15 consecutive nucleotides of at least one biomarker of resistance selected from the group consisting of SEQ ID NOs: 2, 3, 17-26, 31, 32, 35, 37, 42, 43, 45, 46, 71-78, 81, 82, 85-102, 109, 110, 114, 115, 150, 152, 153, 157-161, 163-182, 189, 202, 203, 218, 230, 231, 234, 236, 247, 249-251, 253, 272-274, 277, 283, 284, 286-288, 295, 297, 301, 305, 310, 312, 313, 314, 330, 331, 360-362, 366, 403, 406, 408-410, 430, 439, 451, 452, 470, 490, 491, 499-506, 510, 511, 512, 514, 516, 517, 520, 522-526, 528, and 534-687, wherein said device allows specific hybridization between said at least one second single stranded nucleic acid molecule and said target nucleic acid molecule and is sufficient for detecting the level of expression of said at least one biomarker of sensitivity or said at least one biomarker of resistance, wherein said patient is predicted to be sensitive to said at least one treatment for cancer if the level of expression of said at least one biomarker of sensitivity is substantially similar to the level of expression of said at least one biomarker of sensitivity in a cell or tissue known to be sensitive to said at least one treatment, and wherein said patient is predicted to be resistant to said at least one treatment for cancer if the level of expression of said at least one biomarker of resistance is substantially similar to the level of expression of said at least one biomarker of resistance in a cell or tissue known to be sensitive to said at least one treatment. 3. The method of claim 2, wherein said at least one second single-stranded nucleic acid molecule of said device has 100% sequence identity to said target nucleic acid molecule. 4. The method of claim 2, wherein said method comprises detecting the level of expression of said at least one biomarker of sensitivity or said at least one biomarker of resistance in a biological sample from said patient. 5. The method of claim 2, wherein said device allows the determination of the level of expression of said at least one biomarker of sensitivity having a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 4-12, 36, 118, 146, 209, 241, 252, 260, 280, 308, 395, and 441 or a level of expression of said at least one biomarker of resistance having a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 511 and 538-548. 6. The method of claim 1, wherein said at least one first single-stranded nucleic acid molecule of said device has 100% sequence identity to hsa-miR-766_st (SEQ ID NO: 1). 7. The method of claim 2, wherein said device comprises: i) one or more single-stranded nucleic acid molecules having at least 85% sequence identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-106b-star_st (SEQ ID NO: 2) and hsa-miR-25-star_st (SEQ ID NO: 3), wherein said device allows a determination of the sensitivity of said patient to vincristine; or ii) one or more single-stranded nucleic acid molecules having at least 85% sequence identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from HBII-85-2_x_st (SEQ ID NO: 4), U48_st (SEQ ID NO: 5), U55_x_st (SEQ ID NO: 6), hsa-miR-124_st (SEQ ID NO: 7), hsa-miR-1281_st (SEQ ID NOL: 8), hsa-miR-181a-star_st (SEQ ID NO: 9), hsa-miR-181b_st (SEQ ID NO: 10), hsa-miR-342-3p_st (SEQ ID NO: 11), and hsa-miR-432_st (SEQ ID NO: 12), wherein said device allows a determination of the sensitivity of said patient to cisplatin; or iii) one or more single-stranded nucleic acid molecules having at least 85% sequence identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-124_st (SEQ ID NO: 7), hsa-miR-1281_st (SEQ ID NO: 8), hsa-miR-140-3p_st (SEQ ID NO: 13), hsa-miR-181a-star_st (SEQ ID NO: 9), hsa-miR-181b_st (SEQ ID NO: 10), hsa-miR-195-star_st (SEQ ID NO: 14), hsa-miR-342-3p_st (SEQ ID NO: 11), hsa-miR-766_st (SEQ ID NO: 1), hsa-miR-92b_st (SEQ ID NO: 15), and hsa-miR-938_st (SEQ ID NO: 16), wherein said device allows a determination of the sensitivity of said patient to etoposide; or iv) one or more single-stranded nucleic acid molecules having at least 85% sequence identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-100_st (SEQ ID NO: 17), hsa-miR-140-3p_st (SEQ ID NO: 13), hsa-miR-140-5p_st (SEQ ID NO: 18), hsa-miR-146a_st (SEQ ID NO: 19), hsa-miR-155_st (SEQ ID NO: 20), hsa-miR-506_st (SEQ ID NO: 21), hsa-miR-508-5p_st (SEQ ID NO: 22), hsa-miR-509-3-5p_st (SEQ ID NO: 23), hsa-miR-509-3p_st (SEQ ID NO: 24), hsa-miR-510_st (SEQ ID NO: 25), hsa-miR-513a-5p_st (SEQ ID NO: 26), hsa-miR-513b_st (SEQ ID NO: 27), hsa-miR-663_st (SEQ ID NO: 28), and hsa-miR-923_st (SEQ ID NO: 29), wherein said device allows a determination of the sensitivity of said patient to azaguanine; or v) one or more single-stranded nucleic acid molecules having at least 85% sequence identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from U55_x_st (SEQ ID NO: 6), hsa-miR-124_st (SEQ ID NO: 7), hsa-miR-1271_st (SEQ ID NO: 30), hsa-miR-143_st (SEQ ID NO: 31), hsa-miR-342-3p_st (SEQ ID NO: 11), hsa-miR-370_st (SEQ ID NO: 32), hsa-miR-433_st (SEQ ID NO: 33), hsa-miR-654-3p_st (SEQ ID NO: 34), and hsa-miR-758_st (SEQ ID NO: 35), wherein said device allows a determination of the sensitivity of said patient to carboplatin; or vi) one or more single-stranded nucleic acid molecules having at least 85% sequence identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from U55_st (SEQ ID NO: 36), U55_x_st (SEQ ID NO: 6), hsa-miR-106b-star_st (SEQ ID NO: 2), hsa-miR-106b_st (SEQ ID NO: 37), hsa-miR-124_st (SEQ ID NO: 7), hsa-miR-1299_st (SEQ ID NO: 38), hsa-miR-29b-2-star_st (SEQ ID NO: 39), hsa-miR-33b-star_st (SEQ ID NO: 40), hsa-miR-629-star_st (SEQ ID NO: 41), hsa-miR-652_st (SEQ ID NO: 42), hsa-miR-671-5p_st (SEQ ID NO: 43), hsa-miR-766_st (SEQ ID NO: 1), hsa-miR-768-3p_st (SEQ ID NO: 44), hsa-miR-93-star_st (SEQ ID NO: 45), and hsa-miR-93_st (SEQ ID NO: 46), wherein said device allows a determination of the sensitivity of said patient to adriamycin; or vii) one or more single-stranded nucleic acid molecules having at least 85% sequence identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from ACA10_s_st (SEQ ID NO: 47), ACA18_x_st (SEQ ID NO: 48), ACA44_st (SEQ ID NO: 49), ACA51_x_st (SEQ ID NO: 50), ACA61_st (SEQ ID NO: 51) ENSG00000200394_st (SEQ ID NO: 52), ENSG00000202252_st (SEQ ID NO: 53), HBII-180A_x_st (SEQ ID NO: 54), HBII-429_st (SEQ ID NO: 55) U104_st (SEQ ID NO: 56), U13_st (SEQ ID NO: 57), U17b_st (SEQ ID NO: 58), U17b_x_st (SEQ ID NO: 59), U26_st (SEQ ID NO: 60), U3-2_s_st (SEQ ID NO: 61), U35A_st (SEQ ID NO: 62), U49A_st (SEQ ID NO: 63), U49A_x_st (SEQ ID NO: 64), U49B_s_st (SEQ ID NO: 65), U67_st (SEQ ID NO: 66), U68_st (SEQ ID NO: 67), U68_x_st (SEQ ID NO: 68), U74_x_st (SEQ ID NO: 69), hsa-miR-1275_st (SEQ ID NO: 70), hsa-miR-1281_st (SEQ ID NO: 8), hsa-miR-18a-star_st (SEQ ID NO: 71), hsa-miR-18a_st (SEQ ID NO: 72), hsa-miR-25-star_st (SEQ ID NO: 3), and hsa-miR-33b-star_st (SEQ ID NO: 40), wherein said device allows a determination of the sensitivity of said patient to aclarubicin; or viii) one or more single-stranded nucleic acid molecules having at least 85% sequence identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from 14qII-14_st (SEQ ID NO: 73), 14qII-1_st (SEQ ID NO: 74), 14qII-26_st (SEQ ID NO: 75), 14qII-26_x_st (SEQ ID NO: 76), hsa-miR-127-3p_st (SEQ ID NO: 77), hsa-miR-181a-star_st (SEQ ID NO: 9), hsa-miR-181a_st (SEQ ID NO: 78), hsa-miR-181b_st (SEQ ID NO: 10), hsa-miR-181c_st (SEQ ID NO: 79), hsa-miR-342-3p_st (SEQ ID NO: 11), hsa-miR-342-5p_st (SEQ ID NO: 80), hsa-miR-409-3p_st (SEQ ID NO: 81), hsa-miR-432_st (SEQ ID NO: 12), hsa-miR-487b_st (SEQ ID NO: 82), hsa-miR-654-3p_st (SEQ ID NO: 34), hsa-miR-768-5p_st (SEQ ID NO: 83), and hsa-miR-92b_st (SEQ ID NO: 15), wherein said device allows a determination of the sensitivity of said patient to mitoxantrone; or ix) one or more single-stranded nucleic acid molecules having at least 85% sequence identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-124_st (SEQ ID NO: 7), hsa-miR-181a-star_st (SEQ ID NO: 9), and hsa-miR-181b_st (SEQ ID NO: 10), wherein said device allows a determination of the sensitivity of said patient to mitomycin; or x) one or more single-stranded nucleic acid molecules having at least 85% sequence identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-106b-star_st (SEQ ID NO: 2), hsa-miR-1228_st (SEQ ID NO: 84), hsa-miR-185_st (SEQ ID NO: 85), hsa-miR-188-5p_st (SEQ ID NO: 86), hsa-miR-18b_st (SEQ ID NO: 87), hsa-miR-20b_st (SEQ ID NO: 88), hsa-miR-25_st (SEQ ID NO: 89), hsa-miR-320c_st (SEQ ID NO: 90), hsa-miR-320d_st (SEQ ID NO: 91), hsa-miR-362-5p_st (SEQ ID NO: 92), hsa-miR-500-star_st (SEQ ID NO: 93), hsa-miR-500_st (SEQ ID NO: 94), hsa-miR-501-3p_st (SEQ ID NO: 95), hsa-miR-502-3p_st (SEQ ID NO: 96), hsa-miR-532-3p_st (SEQ ID NO: 97), hsa-miR-532-5p_st (SEQ ID NO: 98), hsa-miR-652_st (SEQ ID NO: 42), and hsa-miR-766_st (SEQ ID NO: 1), wherein said device allow a determination of the sensitivity of said patient to paclitaxel; or xi) one or more single-stranded nucleic acid molecules having at least 85% sequence identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from HBII-438A_s_st (SEQ ID NO: 99), hsa-miR-155_st (SEQ ID NO: 20), hsa-miR-181a-star_st (SEQ ID NO: 9), hsa-miR-181b_st (SEQ ID NO: 10), hsa-miR-342-3p_st (SEQ ID NO: 11), hsa-miR-424-star_st (SEQ ID NO: 100), and hsa-miR-503_st (SEQ ID NO: 101), wherein said device allows a determination of the sensitivity of said patient to gemcitabine; or xii) one or more single-stranded nucleic acid molecules having at least 85% sequence identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-1307_st (SEQ ID NO: 102), hsa-miR-505_st (SEQ ID NO: 103), hsa-miR-769-3p_st (SEQ ID NO: 104), and hsa-miR-769-5p_st (SEQ ID NO: 105), wherein said device allows a determination of the sensitivity of said patient to docetaxel; or xiii) one or more single-stranded nucleic acid molecules having at least 85% sequence identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from U49A_st (SEQ ID NO: 64), U49A_x_st (SEQ ID NO: 106), U49B_s_st (SEQ ID NO: 65), U49B_x_st (SEQ ID NO: 107), hsa-miR-10a-star_st (SEQ ID NO: 108), hsa-miR-1207-5p_st (SEQ ID NO: 109), hsa-miR-128_st (SEQ ID NO: 110), hsa-miR-150_st (SEQ ID NO: 111), hsa-miR-424-star_st (SEQ ID NO: 100), hsa-miR-424_st (SEQ ID NO: 112), hsa-miR-503_st (SEQ ID NO: 101), hsa-miR-766_st (SEQ ID NO: 1), and hsa-miR-768-5p_st (SEQ ID NO: 83), wherein said device allows a determination of the sensitivity of said patient to dexamethasone; or xiv) one or more single-stranded nucleic acid molecules having at least 85% sequence identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from HBII-202_st (SEQ ID NO: 113), HBII-438A_s_st (SEQ ID NO: 114), HBII-85-11_st (SEQ ID NO: 115), U104_st (SEQ ID NO: 116), U17b_st (SEQ ID NO: 117), U17b_x_st (SEQ ID NO: 59), U48_st (SEQ ID NOs: 118), U78_s_st (SEQ ID NO: 119), U78_x_st (SEQ ID NO: 120), hsa-miR-181a-star_st (SEQ ID NO: 9), hsa-miR-181 b_st (SEQ ID NO: 10), hsa-miR-342-3p_st (SEQ ID NO: 11), and hsa-miR-424-star_st (SEQ ID NO: 100), wherein said device allows a determination of the sensitivity of said patient to Ara-C (cytarabine hydrochloride); or xv) one or more single-stranded nucleic acid molecules having at least 85% sequence identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from ACA23_st (SEQ ID NO: 121), ACA24_x_st (SEQ ID NO: 122), ACA54_st (SEQ ID NO: 123), U31_st (SEQ ID NO: 124), hsa-let-7d-star_st (SEQ ID NO: 125), hsa-miR-106b-star_st (SEQ ID NO: 2), hsa-miR-1183_st (SEQ ID NO: 126), hsa-miR-1207-5p_st (SEQ ID NO: 109), hsa-miR-1268_st (SEQ ID NO: 127), hsa-miR-1281_st (SEQ ID NO: 8), hsa-miR-128_st (SEQ ID NO: 110), hsa-miR-150_st (SEQ ID NO: 111), hsa-miR-15a_st (SEQ ID NO: 128), hsa-miR-181a-star_st (SEQ ID NO: 9), hsa-miR-181c_st (SEQ ID NO: 79), hsa-miR-18b_st (SEQ ID NO: 87), hsa-miR-198_st (SEQ ID NO: 129), hsa-miR-20b-star_st (SEQ ID NO: 130), hsa-miR-223_st (SEQ ID NO: 131), hsa-miR-297_st (SEQ ID NO: 132), hsa-miR-342-5p_st (SEQ ID NO: 80), hsa-miR-363_st (SEQ ID NO: 133), hsa-miR-588_st (SEQ ID NO: 134), hsa-miR-631_st (SEQ ID NO: 135), hsa-miR-766_st (SEQ ID NO: 1), hsa-miR-768-5p_st (SEQ ID NO: 83), hsa-miR-92a-2-star_st (SEQ ID NO: 136), and hsa-miR-940_st (SEQ ID NO: 137), wherein said device allows a determination of the sensitivity of said patient to methylprednisolone; or xvi) one or more single-stranded nucleic acid molecules having at least 85% sequence identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from ACA10_s_st (SEQ ID NO: 138), ACA18_x_st (SEQ ID NO: 139), HBII-202_st (SEQ ID NO: 113), U104_st (SEQ ID NO: 140), U17b_st (SEQ ID NO: 117), U30_st (SEQ ID NO: 141), U31_x_st (SEQ ID NO: 142), U49A_st (SEQ ID NO: 143), U49A_x_st (SEQ ID NO: 144), U49B_s_st (SEQ ID NO: 145), U55_st (SEQ ID NO: 146), U55_x_st (SEQ ID NO: 146), U56_st (SEQ ID NO: 147), U67_st (SEQ ID NOs:148), U67_x_st (SEQ ID NO: 149), hsa-miR-106a_st (SEQ ID NO: 150), hsa-miR-1254_st (SEQ ID NO: 151), hsa-miR-1275_st (SEQ ID NO: 70), hsa-miR-17_st (SEQ ID NO: 152), hsa-miR-18a-star_st (SEQ ID NO: 71), hsa-miR-18a_st (SEQ ID NO: 72), hsa-miR-19b_st (SEQ ID NO: 153), hsa-miR-25-star_st (SEQ ID NO: 3), hsa-miR-297_st (SEQ ID NO: 132), hsa-miR-34b_st (SEQ ID NO: 154), hsa-miR-663b_st (SEQ ID NO: 155), and hsa-miR-92a_st (SEQ ID NO: 156), wherein said device allows a determination of the sensitivity of said patient to methotrexate; or xvii) one or more single-stranded nucleic acid molecules having at least 85% sequence identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from 14qII-14_st (SEQ ID NO: 157), 14qII-14_x_st (SEQ ID NO: 158), 14qII-1_st (SEQ ID NO: 159), 14qII-1_x_st (SEQ ID NO: 74), 14qII-26_st (SEQ ID NOs: 160), 14qII-26_x_st (SEQ ID NO: 161), 14qII-3_st (SEQ ID NO: 162), hsa-miR-125b-1-star_st (SEQ ID No: 163), hsa-miR-127-3p_st (SEQ ID NO: 77), hsa-miR-1271_st (SEQ ID NO: 30), hsa-miR-134_st (SEQ ID NO: 164), hsa-miR-155_st (SEQ ID NO: 20), hsa-miR-193a-5p_st (SEQ ID NO: 165), hsa-miR-21-star_st (SEQ ID NO: 166), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-299-3p_st (SEQ ID NO: 168), hsa-miR-337-5p_st (SEQ ID NO: 169), hsa-miR-370_st (SEQ ID NO: 32), hsa-miR-376c_st (SEQ ID NO: 170), hsa-miR-377-star_st (SEQ ID NO: 171), hsa-miR-379_st (SEQ ID NO: 172), hsa-miR-381_st (SEQ ID NO: 173), hsa-miR-382_st (SEQ ID NO: 174), hsa-miR-409-3p_st (SEQ ID NO: 81), hsa-miR-409-5p_st (SEQ ID NO: 175), hsa-miR-411_st (SEQ ID NO: 176), hsa-miR-431_st (SEQ ID NO: 177), hsa-miR-455-3p_st (SEQ ID NO: 178), hsa-miR-485-5p_st (SEQ ID NO: 179), hsa-miR-487b_st (SEQ ID NO: 82), hsa-miR-493_st (SEQ ID NO: 180), hsa-miR-494_st (SEQ ID NO: 181), hsa-miR-543_st (SEQ ID NO: 182), hsa-miR-663_st (SEQ ID NO: 28), hsa-miR-671-5p_st (SEQ ID NO: 43), and hsa-miR-758_st (SEQ ID NO: 35), wherein said device allows a determination of the sensitivity of said patient to bleomycin; or xviii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from ENSG00000200879_st (SEQ ID NO: 183), ENSG00000202252_st (SEQ ID NO: 184), HBII-202_st (SEQ ID NO: 185), U25_st (SEQ ID NO: 186), U26_st (SEQ ID NO: 187), U28_x_st (SEQ ID NO: 188), U29_st (SEQ ID NO: 189), U30_st (SEQ ID NO: 141), U31_x_st (SEQ ID NO: 190), U74_x_st (SEQ ID NO: 191), hsa-miR-181a-star_st (SEQ ID NO: 9), hsa-miR-297_st (SEQ ID NO: 132), hsa-miR-34b_st (SEQ ID NO: 154), and hsa-miR-92a-1-star_st (SEQ ID NO: 192), wherein said device allows a determination of the sensitivity of said patient to methyl-GAG (methyl glyoxal bis amidinohydrazone dihydrochloride); or xix) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from ACA18_x_st (SEQ ID NO: 193), ACA51_x_st (SEQ ID NO: 194), ACA9_st (SEQ ID NO: 195), ACA9_x_st (SEQ ID NO: 196), HBII-180A_x_st (SEQ ID NO: 197), HBII-202_st (SEQ ID NO: 198), HBII-336_st (SEQ ID NO: 199), HBII-55_st (SEQ ID NO: 200), U104_st (SEQ ID NO: 201), U27_st (SEQ ID NO: 202), U29_st (SEQ ID NO: 203), U30_st (SEQ ID NO: 204), U31_st (SEQ ID NO: 205), U31_x_st (SEQ ID NO: 206), U38A_st (SEQ ID NO: 207), U55_st (SEQ ID NO: 208), U55_x_st (SEQ ID NO: 209), U56_st (SEQ ID NO: 210), U56_x_st (SEQ ID NO: 211), U57_st (SEQ ID NO: 212), U60_st (SEQ ID NO: 213), U74_x_st (SEQ ID NO: 191), hsa-miR-106a_st (SEQ ID NO: 150), hsa-miR-1183_st (SEQ ID NO: 126), hsa-miR-1207-5p_st (SEQ ID NO: 109), hsa-miR-1246_st (SEQ ID NO: 214), hsa-miR-1268_st (SEQ ID NO: 127), hsa-miR-1299_st (SEQ ID NO: 38), hsa-miR-1307_st (SEQ ID NO: 102), hsa-miR-142-5p_st (SEQ ID NO: 215), hsa-miR-17-star_st (SEQ ID NO: 216), hsa-miR-17_st (SEQ ID NO: 152), hsa-miR-18a-star_st (SEQ ID NO: 71), hsa-miR-18a_st (SEQ ID NO: 72), hsa-miR-18b_st (SEQ ID NO: 87), hsa-miR-195-star_st (SEQ ID. NO: 14), hsa-miR-19a_st (SEQ ID NO: 217), hsa-miR-19b_st (SEQ ID No: 153), hsa-miR-20a_st (SEQ ID NO: 218), hsa-miR-20b_st (SEQ ID NO: 88), hsa-miR-297_st (SEQ ID NO: 132), hsa-miR-330-3p_st (SEQ ID NO: 219), hsa-miR-346_st (SEQ ID NO: 220), hsa-miR-34b_st (SEQ ID NO: 154), hsa-miR-595_st (SEQ ID NO: 221), hsa-miR-629-star_st (SEQ ID NO: 41), hsa-miR-647_st (SEQ ID NO: 222), hsa-miR-766_st (SEQ ID NO: 1), hsa-miR-768-5p_st (SEQ ID NO: 83), and hsa-miR-92a_st (SEQ ID NO: 156), wherein said device allows a determination of the sensitivity of said patient to belinostat (PXD101); or xx) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from ACA10_s_st (SEQ ID NO: 223), ENSG00000199411_s_st (SEQ ID NO: 224), U104_st (SEQ ID NO: 201), U13_st (SEQ ID NO: 225), U36A_x_st (SEQ ID NO: 226), U36C_st (SEQ ID NO: 227), U74_x_st (SEQ ID NO: 69), U78_x_st (SEQ ID NO: 228), U8_x_st (SEQ ID NO: 229), hsa-miR-1246_st (SEQ ID NO: 214), hsa-miR-194-star_st (SEQ ID NO: 230), hsa-miR-200c-star_st (SEQ ID NO: 231), hsa-miR-34b_st (SEQ ID NO: 154), and hsa-miR-768-3p_st (SEQ ID NO: 44), wherein said device allows a determination of the sensitivity of said patient to 5-fluorouracil; or xxi) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-106a_st (SEQ ID NO: 150), hsa-miR-106b-star_st (SEQ ID NO: 2), hsa-miR-1183_st (SEQ ID NO: 126), hsa-miR-195-star_st (SEQ ID NO: 14), hsa-miR-297_st (SEQ ID NO: 132), hsa-miR-324-3p_st (SEQ ID NO: 235), hsa-miR-34b_st (SEQ ID NO: 154), hsa-miR-371-5p_st (SEQ ID NO: 236), hsa-miR-766_st (SEQ ID NO:1), hsa-miR-92a_st (SEQ ID NO: 156), and hsa-miR-93-star_st (SEQ ID NO: 45), wherein said device allows a determination of the sensitivity of said patient to 5-Aza-2'-deoxycytidine (decitabine); or xxii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from ACA41_x_st (SEQ ID NO: 237), ACA48_x_st (SEQ ID NO: 238), HBII-202_st (SEQ ID NO: 239), HBII-429_st (SEQ ID NO: 240), U104_st (SEQ ID NO: 140), U49A_st (SEQ ID NO: 63), U49B_s_st (SEQ ID NO: 145), U55_st (SEQ ID NO: 6), U55_x_st (SEQ ID NO: 241), U74_x_st (SEQ ID NO: 242), hsa-miR-124_st (SEQ ID NO: 7), hsa-miR-1299_st (SEQ ID NO: 38), hsa-miR-181a-star_st (SEQ ID NO: 9), hsa-miR-297_st (SEQ ID NO: 132), hsa-miR-342-5p_st (SEQ ID NO: 80), hsa-miR-34b_st (SEQ ID NO: 154), hsa-miR-631_st (SEQ ID NO: 135), hsa-miR-768-3p_st (SEQ ID NO: 44), and hsa-miR-768-5p_st (SEQ ID NO: 83), wherein said device allows a determination of the sensitivity of said patient to idarubicin; or xxiii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from ACA7_s_st (SEQ ID NOs: 243), ENSG00000202252_st (SEQ ID NO: 244), ENSG00000207002_x_st (SEQ ID NO: 245), HBII-202_st (SEQ ID NO: 113), HBII-429_st (SEQ ID NO: 246), HBII-438A_s_st (SEQ ID NO: 247), HBII-55_st (SEQ ID NO: 248), HBII-85-11_st (SEQ ID NO: 249), HBII-85-23_x_st (SEQ ID NO: 250), HBII-85-26_st (SEQ ID NO: 251), HBII-85-2_x_st (SEQ ID NO: 252), HBII-85-6_x_st (SEQ ID NO: 253), U104_st (SEQ ID NO: 140), U13_st (SEQ ID NO: 225), U17b_st (SEQ ID NO: 254), U17b_x_st (SEQ ID NO: 59), U33_st (SEQ ID NO: 255), U34_st (SEQ ID NO: 256), U41_st (SEQ ID NO: 257), U52_st (SEQ ID NO: 258), U55_st (SEQ ID NO: 259), U55_x_st (SEQ ID NOs: 260), U56_st (SEQ ID NO: 261), U57_st (SEQ ID NO: 262), U68_st (SEQ ID NO: 263), U74_x_st (SEQ ID NO: 264), U78_s_st (SEQ ID NO: 265), U78_x_st (SEQ ID NO: 266), U83_st (SEQ ID NO: 267), U95_st (SEQ ID NO: 268), hsa-miR-1183_st (SEQ ID NO: 126), hsa-miR-1207-5p_st (SEQ ID NO: 109), hsa-miR-1228_st (SEQ ID NO: 84), hsa-miR-124_st (SEQ ID NO: 7), hsa-miR-1281_st (SEQ ID NO: 8), hsa-miR-1299_st (SEQ ID NO: 38), hsa-miR-140-3p_st (SEQ ID NO: 13), hsa-miR-142-5p_st (SEQ ID NO: 215), hsa-miR-181a-star_st (SEQ ID NO: 9), hsa-miR-181a_st (SEQ ID NO: 78), hsa-miR-181b_st (SEQ ID NO: 10), hsa-miR-181c_st (SEQ ID NO: 79), hsa-miR-195-star_st (SEQ ID NO: 14), hsa-miR-223_st (SEQ ID NO: 131), hsa-miR-297_st (SEQ ID NO: 132), hsa-miR-29b-2-star_st (SEQ ID NO: 39), hsa-miR-342-3p_st (SEQ ID NO: 11), hsa-miR-342-5p_st (SEQ ID NO: 80), hsa-miR-34b_st (SEQ ID NO: 154), hsa-miR-541-star_st (SEQ ID NO: 269), hsa-miR-610_st (SEQ ID NO: 270), hsa-miR-647_st (SEQ ID NO: 222), hsa-miR-766_st (SEQ ID NO: 1), hsa-miR-768-3p_st (SEQ ID NO: 44), hsa-miR-768-5p_st (SEQ ID NO: 83), and hsa-miR-885-5p_st (SEQ ID NO: 271), wherein said device allows a determination of the sensitivity of said patient to melphalan; or xxiv) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-1246_st (SEQ ID NO: 214), hsa-miR-150_st (SEQ ID NO: 111), hsa-miR-339-3p_st (SEQ ID NO: 272), hsa-miR-339-5p_st (SEQ ID NO: 273), and hsa-miR-768-3p_st (SEQ ID NO: 44), wherein said device allows a determination of the sensitivity of said patient to IL4-PR38 fusion protein; or xxv) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-1308_st (SEQ ID NO: 274), hsa-miR-148a_st (SEQ ID NO: 275), hsa-miR-152_st (SEQ ID NO: 276), hsa-miR-34a-star_st (SEQ ID NO: 277), and hsa-miR-34a_st (SEQ ID NO: 234), wherein said device allows a determination of the sensitivity of said patient to valproic acid; or xxvi) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from HBII-142_st (SEQ ID NO: 278), HBII-142_x_st (SEQ ID NO: 279), U55_st (SEQ ID NO: 6), U55_x_st (SEQ ID NO: 280), hsa-miR-1202_st (SEQ ID NO: 281), hsa-miR-124_st (SEQ ID NO: 7), hsa-miR-148a-star_st (SEQ ID NO: 282), hsa-miR-148a_st (SEQ ID NO: 275), hsa-miR-184_st (SEQ ID NO: 283), hsa-miR-191_st (SEQ ID NO: 284), hsa-miR-195-star_st (SEQ ID NO: 14), hsa-miR-29b-2-star_st (SEQ ID NO: 39), hsa-miR-425-star_st (SEQ ID NO: 285), hsa-miR-425_st (SEQ ID NO: 286), hsa-miR-449a_st (SEQ ID NO: 287), hsa-miR-449b_st (SEQ ID NO: 288), hsa-miR-551 b_st (SEQ ID NO: 289), hsa-miR-593-star_st (SEQ ID NO: 290), hsa-miR-768-3p_st (SEQ ID NO: 44), hsa-miR-768-5p_st (SEQ ID NO: 83), and hsa-miR-877_st (SEQ ID NO: 291), wherein said device allows a determination of the sensitivity of said patient to all-trans retinoic acid (ATRA); or xxvii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from ENSG00000200879_st (SEQ ID NO: 292), ENSG00000202252_st (SEQ ID NO: 244), HBII-142_st (SEQ ID NO: 293), hsa-miR-1202_st (SEQ ID NO: 281), hsa-miR-184_st (SEQ ID NO: 283), hsa-miR-196a_st (SEQ ID NO: 294), hsa-miR-205_st (SEQ ID NO: 295), hsa-miR-29b-2-star_st (SEQ ID NO: 39), hsa-miR-29c-star_st (SEQ ID NO: 296), hsa-miR-375_st (SEQ ID NO: 297), hsa-miR-449a_st (SEQ ID NO: 287), hsa-miR-449b_st (SEQ ID NO: 288), hsa-miR-489_st (SEQ ID NO: 298), and hsa-miR-768-3p_st (SEQ ID NO: 44), wherein said device allows a determination of the sensitivity of said patient to cytoxan; or xxviii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-155_st (SEQ ID NO: 20), hsa-miR-181 b_st (SEQ ID NO: 10), hsa-miR-342-3p_st (SEQ ID NO: 11), hsa-miR-342-5p_st (SEQ ID NO: 80), hsa-miR-424-star_st (SEQ ID NO: 100), and hsa-miR-503_st (SEQ ID NO: 101), wherein said device allows a determination of the sensitivity of said patient to topotecan; or xxix) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from U56_x_st (SEQ ID NO: 211), hsa-miR-106a_st (SEQ ID NO: 150), hsa-miR-126_st (SEQ ID NO: 299), hsa-miR-128_st (SEQ ID NO: 110), hsa-miR-148a-star_st (SEQ ID NO: 282), hsa-miR-148a_st (SEQ ID NO: 275), hsa-miR-153_st (SEQ ID NO: 300), hsa-miR-17_st (SEQ ID NO: 152), hsa-miR-18a-star_st (SEQ ID NO: 71), hsa-miR-18a_st (SEQ ID NO: 72), hsa-miR-18b_st (SEQ ID NO: 87), hsa-miR-19a_st (SEQ ID NO: 217), hsa-miR-19b_st (SEQ ID NO: 153), hsa-miR-20a_st (SEQ ID NO: 218), hsa-miR-20b_st (SEQ ID NO: 88), hsa-miR-25_st (SEQ ID NO: 89), hsa-miR-30c_st (SEQ ID NO: 301), hsa-miR-30e_st (SEQ ID NO: 302), hsa-miR-363-star_st (SEQ ID NO: 303), hsa-miR-363_st (SEQ ID NO: 133), hsa-miR-766_st (SEQ ID NO: 1), and hsa-miR-92a_st (SEQ ID NO: 156), wherein said device allows a determination of the sensitivity of said patient to suberoylanilide hydroxamic acid (SAHA, vorinostat); or xxx) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-185_st (SEQ ID NO: 85), hsa-miR-188-5p_st (SEQ ID NO: 86), hsa-miR-362-5p_st (SEQ ID NO: 92), hsa-miR-500-star_st (SEQ ID NO: 93), hsa-miR-500_st (SEQ ID NO: 94), hsa-miR-501-3p_st (SEQ ID NO: 95), hsa-miR-501-5p_st (SEQ ID NO: 304), hsa-miR-502-3p_st (SEQ ID NO: 96), hsa-miR-532-3p_st (SEQ ID NO: 97), hsa-miR-532-5p_st (SEQ ID NO: 98), hsa-miR-652_st (SEQ ID NO: 42), hsa-miR-660_st (SEQ ID NO: 305), and hsa-miR-93_st (SEQ ID NO: 46), wherein said device allows allowing a determination of the sensitivity of said patient to depsipeptide (FR901228); or xxxi) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-106b-star_st (SEQ ID NO: 2), hsa-miR-106b_st (SEQ ID NO: 37), hsa-miR-1307_st (SEQ ID NO: 102), hsa-miR-188-5p_st (SEQ ID NO: 86), hsa-miR-25-star_st (SEQ ID NO: 3), hsa-miR-25_st (SEQ ID NO: 89), hsa-miR-320c_st (SEQ ID NO: 90), hsa-miR-324-3p_st (SEQ ID NO: 235), hsa-miR-500_st (SEQ ID NO: 94), hsa-miR-501-5p_st (SEQ ID NO: 304), hsa-miR-638_st (SEQ ID NO: 306), hsa-miR-652_st (SEQ ID NO: 42), hsa-miR-93-star_st (SEQ ID NO: 45), and hsa-miR-93_st (SEQ ID NO: 46), wherein said device allows a determination of the sensitivity of said patient to bortezomib; or xxxii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from HBII-85-2_x_st (SEQ ID NO: 252), U104_st (SEQ ID NO: 201), U41_st (SEQ ID NO: 307), U52_st (SEQ ID NO: 258), U55_st (SEQ ID NO: 6), U55_x_st (SEQ ID NO: 308), U57_st (SEQ ID NO: 262), U74_x_st (SEQ ID NO: 309), hsa-miR-124_st (SEQ ID NO: 7), hsa-miR-1281_st (SEQ ID NO: 8), hsa-miR-1299_st (SEQ ID NO: 38), hsa-miR-140-3p_st (SEQ ID NO: 13), hsa-miR-142-5p_st (SEQ ID NO: 215), hsa-miR-181a-star_st (SEQ ID NO: 9), hsa-miR-181a_st (SEQ ID NO: 78), hsa-miR-181b_st (SEQ ID NO: 10), hsa-miR-181c_st (SEQ ID NO: 79), hsa-miR-195-star_st (SEQ ID NO: 14), hsa-miR-223_st (SEQ ID NO: 131), hsa-miR-297_st (SEQ ID NO: 132), hsa-miR-342-3p_st (SEQ ID NO: 11), hsa-miR-342-5p_st (SEQ ID NO: 80), hsa-miR-34b_st (SEQ ID NO: 154), hsa-miR-766_st (SEQ ID NO: 1), hsa-miR-768-5p_st (SEQ ID NO: 83), and hsa-miR-874_st (SEQ ID NO: 310), wherein said device allows a determination of the sensitivity of said patient to leukeran; or xxxiii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from HBII-276_st (SEQ ID NO: 311), HBII-438A_s_st (SEQ ID NO: 247), HBII-52-32_x_st (SEQ ID NO: 312), HBII-85-11_st (SEQ ID NO: 115), hsa-miR-130a_st (SEQ ID NO: 313), hsa-miR-155_st (SEQ ID NO: 20), hsa-miR-181a-star_st (SEQ ID NO: 9), hsa-miR-181a_st (SEQ ID NO: 78), hsa-miR-181b_st (SEQ ID NO: 10), hsa-miR-20b-star_st (SEQ ID NO: 130), hsa-miR-20b_st (SEQ ID NO: 88), hsa-miR-34c-3p_st (SEQ ID NO: 314), hsa-miR-363_st (SEQ ID NO: 133), hsa-miR-424-star_st (SEQ ID NO: 100), hsa-miR-503_st (SEQ ID NO: 101), hsa-miR-554_st (SEQ ID NO: 315), and hsa-miR-766_st (SEQ ID NO: 1), wherein said device allows a determination of the sensitivity of said patient to fludarabine; or xxxiv) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-106b-star_st (SEQ ID NO: 2), hsa-miR-25-star_st (SEQ ID NO: 3), hsa-miR-362-5p_st (SEQ ID NO: 92), hsa-miR-500-star_st (SEQ ID NO: 93), hsa-miR-500_st (SEQ ID NO: 94), hsa-miR-502-3p_st (SEQ ID NO: 96), hsa-miR-532-5p_st (SEQ ID NO: 98), hsa-miR-652_st (SEQ ID NO: 42), and hsa-miR-671-5p_st (SEQ ID NO: 43), wherein said device allows a determination of the sensitivity of said patient to vinblastine; or xxxv) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from U55_st (SEQ ID NO: 308), U55_x_st (SEQ ID NO: 6), hsa-miR-1207-5p_st (SEQ ID NO: 109), hsa-miR-1246_st (SEQ ID NO: 214), hsa-miR-1281_st (SEQ ID NO: 8), hsa-miR-181a-star_st (SEQ ID NO: 9), hsa-miR-181b_st (SEQ ID NO: 10), hsa-miR-181c_st (SEQ ID NO: 79), hsa-miR-297_st (SEQ ID NO: 132), hsa-miR-766_st (SEQ ID NO: 1), and hsa-miR-923_st (SEQ ID NO: 29), wherein said device allows a determination of the sensitivity of said patient to busulfan; or xxxvi) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from U13_st (SEQ ID NO: 316), U17a_st (SEQ ID NO: 317), U25_st (SEQ ID NO: 318), U29_st (SEQ ID NO: 203), U3-2_s_st (SEQ ID NO: 319), U41_st (SEQ ID NO: 307), U52_st (SEQ ID NO: 320), U55_st (SEQ ID NO: 241), hsa-miR-1207-5p_st (SEQ ID NO: 109), hsa-miR-1299_st (SEQ ID NO: 38), hsa-miR-140-3p_st (SEQ ID NO: 13), hsa-miR-140-5p_st (SEQ ID NO: 18), hsa-miR-17-star_st (SEQ ID NO: 216), hsa-miR-181d_st (SEQ ID NO: 321), hsa-miR-223_st (SEQ ID NO: 131), hsa-miR-297_st (SEQ ID NO: 132), hsa-miR-34b_st (SEQ ID NO: 154), hsa-miR-766_st (SEQ ID NO: 1), hsa-miR-92a-1-star_st (SEQ ID NO: 192), and hsa-miR-92a_st (SEQ ID NO: 156), wherein said device allows a determination of the sensitivity of said patient to dacarbazine; or xxxvii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from ACA10_s_st (SEQ ID NO: 138), ACA15_s_st (SEQ ID NO: 322), ACA18_x_st (SEQ ID NO: 139), ACA21_st (SEQ ID NO: 323), ACA51_x_st (SEQ ID NO: 324), HBII-180A_x_st (SEQ ID NO: 54), HBII-202_st (SEQ ID NO: 113), HBII-429_st (SEQ ID NO: 55), HBII-55_st (SEQ ID NO: 248), HBII-99_st (SEQ ID NO: 325), U104_st (SEQ ID NO: 326), U17b_st (SEQ ID NO: 327), U17b_x_st (SEQ ID NO: 328), U25_st (SEQ ID NO: 329), U27_st (SEQ ID NO: 330), U29_st (SEQ ID NO: 331), U30_st (SEQ ID NO: 332), U31_st (SEQ ID NO: 124), U31_x_st (SEQ ID NO: 333), U33_st (SEQ ID NO: 334), U36C_st (SEQ ID NO: 335), U50B_st (SEQ ID NO: 336), U55_st (SEQ ID NO: 241), U55_x_st (SEQ ID NO: 260), U56_st (SEQ ID NO: 337), U56_x_st (SEQ ID NO: 338), U57_st (SEQ ID NO: 339), U71d_x_st (SEQ ID NO: 340), U73a_st (SEQ ID NO: 341), U74_x_st (SEQ ID NO: 69), U78_s_st (SEQ ID NO: 265), U78_x_st (SEQ ID NO: 266), U95_st (SEQ ID NO: 268), hsa-miR-106a_st (SEQ ID NO: 150), hsa-miR-106b_st (SEQ ID NO: 37), hsa-miR-1246_st (SEQ ID NO: 214), hsa-miR-1275_st (SEQ ID NO: 70), hsa-miR-1307_st (SEQ ID NO: 102), hsa-miR-142-5p_st (SEQ ID NO: 215), hsa-miR-148a-star_st (SEQ ID NO: 282), hsa-miR-153_st (SEQ ID NO: 300), hsa-miR-17-star_st (SEQ ID NO: 216), hsa-miR-17_st (SEQ ID NO: 152), hsa-miR-18a-star_st (SEQ ID NO: 71), hsa-miR-18a_st (SEQ ID NO: 72), hsa-miR-18b_st (SEQ ID NO: 87), hsa-miR-19a_st (SEQ ID NO: 217), hsa-miR-19b_st (SEQ ID NO: 153), hsa-miR-20a_st (SEQ ID NO: 218), hsa-miR-297_st (SEQ ID NO: 132), hsa-miR-301a_st (SEQ ID NO: 342), and hsa-miR-34b_st (SEQ ID NO: 154), wherein said device allows a determination of the sensitivity of said patient to oxaliplatin; or xxxviii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from ACA7_s_st (SEQ ID NO: 243), ENSG00000199282_st (SEQ ID NO: 343), ENSG00000201859_x_st (SEQ ID NO: 344), HBII-202_st (SEQ ID NO: 239), HBII-336_st (SEQ ID NO: 345), HBII-429_st (SEQ ID NO: 246), U104_st (SEQ ID NO: 140), U25_st (SEQ ID NO: 329), U33_st (SEQ ID NO: 346), U34_st (SEQ ID NO: 347), U38A_st (SEQ ID NO: 348), U41_st (SEQ ID NO: 307), U49B_s_st (SEQ ID NO: 107), U52_st (SEQ ID NO: 349), U55_st (SEQ ID NO: 6), U55_x_st (SEQ ID NO: 260), U74_x_st (SEQ ID NO: 350), hsa-miR-1207-5p_st (SEQ ID NO: 109), hsa-miR-124_st (SEQ ID NO: 7), hsa-miR-1281_st (SEQ ID NO: 8), hsa-miR-1299_st (SEQ ID NO: 38), hsa-miR-140-3p_st (SEQ ID NO: 13), hsa-miR-155_st (SEQ ID NO: 20), hsa-miR-181a-star_st (SEQ ID NO: 9), hsa-miR-181b_st (SEQ ID NO: 10), hsa-miR-181c_st (SEQ ID NO: 79), hsa-miR-195-star_st (SEQ ID NO: 14), hsa-miR-223_st (SEQ ID NO: 131), hsa-miR-297_st (SEQ ID NO: 132), hsa-miR-34b_st (SEQ ID NO: 154), hsa-miR-491-3p_st (SEQ ID NO: 351), hsa-miR-595_st (SEQ ID NO: 221), hsa-miR-631_st (SEQ ID NO: 135), hsa-miR-766_st (SEQ ID NO: 1), and hsa-miR-768-5p_st (SEQ ID NO: 83), wherein said device allows a determination of the sensitivity of said patient to hydroxyurea; or xxxix) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from HBII-180A_x_st (SEQ ID NO: 352), U104_st (SEQ ID NO: 353), U33_st (SEQ ID NO: 354), U34_st (SEQ ID NO: 355), U43_x_st (SEQ ID NO: 356), U51_st (SEQ ID NO: 357), U55_x_st (SEQ ID NO: 36), U74_x_st (SEQ ID NO: 191), U78_s_st (SEQ ID NO: 119), U78_x_st (SEQ ID NO: 228), hsa-miR-1228-star_st (SEQ ID NO: 358), hsa-miR-1246_st (SEQ ID NO: 214), hsa-miR-124_st (SEQ ID NO: 7), hsa-miR-1299_st (SEQ ID NO: 38), hsa-miR-1307_st (SEQ ID NO: 102), hsa-miR-149-star_st (SEQ ID NO: 359), hsa-miR-16_st (SEQ ID NO: 360), hsa-miR-18a_st (SEQ ID NO: 72), hsa-miR-195-star_st (SEQ ID NO: 14), hsa-miR-297_st (SEQ ID NO: 132), hsa-miR-330-3p_st (SEQ ID NO: 219), hsa-miR-346_st (SEQ ID NO: 220), hsa-miR-34b_st (SEQ ID NO: 154), hsa-miR-638_st (SEQ ID NO: 306), hsa-miR-923_st (SEQ ID NO: 29), and hsa-miR-92a_st (SEQ ID NO: 156), wherein said device allows a determination of the sensitivity of said patient to tegafur; or xl) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from ACA48_x_st (SEQ ID NO: 238), HBII-85-26_st (SEQ ID NO: 361), HBII-85-6_x_st (SEQ ID NO: 362), U104_st (SEQ ID NO: 140), U55_st (SEQ ID NO: 280), U55_x_st (SEQ ID NO: 308), U74_x_st (SEQ ID NO: 264), hsa-miR-106a-star_st (SEQ ID NO: 363), hsa-miR-106bstar_st (SEQ ID NO: 2), hsa-miR-106b_st (SEQ ID NO: 37), hsa-miR-124_st (SEQ ID NO: 7), hsa-miR-1281_st (SEQ ID NO: 8), hsa-miR-1299_st (SEQ ID NO: 38), hsa-miR-181a-star_st (SEQ ID NO: 9), hsa-miR-195-star_st (SEQ ID NO: 14), hsa-miR-297_st (SEQ ID NO: 132), hsa-miR-29b-2-star_st (SEQ ID NO: 39), hsa-miR-33b-star_st (SEQ ID NO: 40), hsa-miR-342-5p_st (SEQ ID NO: 80), hsa-miR-34b_st (SEQ ID NO: 154), hsa-miR-629-star_st (SEQ ID NO: 41), hsa-miR-652_st (SEQ ID NO: 42), hsa-miR-671-5p_st (SEQ ID NO: 43), hsa-miR-766_st (SEQ ID NO: 1), hsa-miR-768-3p_st (SEQ ID NO: 44), hsa-miR-768-5p_st (SEQ ID NO: 83), hsa-miR-877-star_st (SEQ ID NO: 364), hsa-miR-93-star_st (SEQ ID NO: 45), and hsa-miR-93_st (SEQ ID NO: 46), wherein said device allows a determination of the sensitivity of said patient to daunorubicin; or xli) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from 14qII-14_st (SEQ ID NO: 157), 14qII-14_x_st (SEQ ID NO: 158), 14qII-1_st (SEQ ID NO: 159), 14qII-1_x_st (SEQ ID NO: 74), 14qII-26_st (SEQ ID NO: 160), 14qII-26_x_st (SEQ ID NO: 161), 14qII-3_st (SEQ ID NO: 162), hsa-miR-125b-1-star_st (SEQ ID NO: 163), hsa-miR-127-3p_st (SEQ ID NO: 77), hsa-miR-1271_st (SEQ ID NO: 30), hsa-miR-134_st (SEQ ID NO: 164), hsa-miR-155_st (SEQ ID NO: 20), hsa-miR-193a-5p_st (SEQ ID NO: 165), hsa-miR-21-star_st (SEQ ID NO: 166), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-299-3p_st (SEQ ID NO: 168), hsa-miR-337-5p_st (SEQ ID NO: 169), hsa-miR-370_st (SEQ ID NO: 32), hsa-miR-376c_st (SEQ ID NO: 170), hsa-miR-377-star_st (SEQ ID NO: 171), hsa-miR-379_st (SEQ ID NO: 172), hsa-miR-381_st (SEQ ID NO: 173), hsa-miR-382_st (SEQ ID NO: 174), hsa-miR-409-3p_st (SEQ ID NO: 81), hsa-miR-409-5p_st (SEQ ID NO: 175), hsa-miR-411_st (SEQ ID NO: 176), hsa-miR-431_st (SEQ ID NO: 177), hsa-miR-455-3p_st (SEQ ID NO: 178), hsa-miR-485-5p_st (SEQ ID NO: 179), hsa-miR-487b_st (SEQ ID NO: 82), hsa-miR-493_st (SEQ ID NO:180), hsa-miR-494_st (SEQ ID NO: 181), hsa-miR-543_st (SEQ ID NO: 182), hsa-miR-663_st (SEQ ID NO: 28), hsa-miR-671-5p_st (SEQ ID NO: 43), and hsa-miR-758_st (SEQ ID NO: 35), wherein said device allows a determination of the sensitivity of said patient to bleomycin; or xlii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-1226_st (SEQ ID NO: 365), hsa-miR-193a-3p_st (SEQ ID NO: 366), hsa-miR-193a-5p_st (SEQ ID NO: 165), hsa-miR-330-3p_st (SEQ ID NO: 219), hsa-miR-330-5p_st (SEQ ID NO: 367), hsa-miR-378_st (SEQ ID NO: 368), and hsa-miR-586_st (SEQ ID NO: 369), wherein said device allows a determination of the sensitivity of said patient to estramustine; or xliii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from ACA13_st (SEQ ID NO: 370), ACA21_st (SEQ ID NO: 323), ACA48_x_st (SEQ ID NO: 371), ACA7_s_st (SEQ ID NO: 372), ACA9_st (SEQ ID NO: 373), ENSG00000202252_st (SEQ ID NO: 184), HBII-202_st (SEQ ID NO: 198), HBII-239_st (SEQ ID NO: 374), HBII-336_st (SEQ ID NO: 345), HBII-429_st (SEQ ID NO: 240), U104_st (SEQ ID NO: 140), U33_st (SEQ ID NO: 375), U34_st (SEQ ID NO: 376), U52_st (SEQ ID NO: 258), U55_st (SEQ ID NO: 308), U55_x_st (SEQ ID NO: 260), U74_x_st (SEQ ID NO: 377), U75_st (SEQ ID NO: 378), U78_s_st (SEQ ID NO: 265), U78_x_st (SEQ ID NO: 120), U95_st (SEQ ID NO: 379), hsa-miR-124_st (SEQ ID NO: 7), hsa-miR-1281_st (SEQ ID NO: 8), hsa-miR-1299_st (SEQ ID NO: 38), hsa-miR-142-5p_st (SEQ ID NO: 215), hsa-miR-181a-star_st (SEQ ID NO: 9), hsa-miR-181a_st (SEQ ID NO: 78), hsa-miR-181b_st (SEQ ID NO: 10), hsa-miR-195-star_st (SEQ ID NO: 14), hsa-miR-297_st (SEQ ID NO: 132), hsa-miR-29b-2-star_st (SEQ ID NO: 39), hsa-miR-331-5p_st (SEQ ID NO: 380), hsa-miR-34b_st (SEQ ID NO: 154), hsa-miR-425_st (SEQ ID NO: 286), hsa-miR-766_st (SEQ ID NO: 1), hsa-miR-768-3p_st (SEQ ID NO: 44), and hsa-miR-768-5p_st (SEQ ID NO: 83), wherein said device allows a determination of the sensitivity of said patient to mechlorethamine; or xliv) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-296-3p_st (SEQ ID NO: 381) and hsa-miR-923_st (SEQ ID NO: 29), wherein said device allows a determination of the sensitivity of said patient to streptozocin; or xlv) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from ACA10_s_st (SEQ ID NO: 382), ACA44_st (SEQ ID NO: 383), ACA52_st (SEQ ID NO: 384), ACA61_st (SEQ ID NO: 385), HBII-142_st (SEQ ID NO: 278), HBII-180A_x_st (SEQ ID NO: 386), HBII-382_s_st (SEQ ID NO: 387), HBII-429_st (SEQ ID NO: 388), U13_st (SEQ ID NO: 389), U17a_st (SEQ ID NO: 390), U17a_x_st (SEQ ID NO: 391), U17b_st (SEQ ID NO: 58), U17b_x_st (SEQ ID NO: 392), U38A_st (SEQ ID NO: 393), U41_st (SEQ ID NO: 394), U48_st (SEQ ID NO: 395), U52_st (SEQ ID NO: 396), U55_st (SEQ ID NO: 146), U55_x_st (SEQ ID NO: 280), U67_st (SEQ ID NO: 66), U67_x_st (SEQ ID NO: 397), U70_x_st (SEQ ID NO: 398), U74_x_st (SEQ ID NO: 399), U83B_st (SEQ ID NO: 400), hsa-miR-106a_st (SEQ ID NO: 150), hsa-miR-1274a_st (SEQ ID NO: 401), hsa-miR-1275_st (SEQ ID NO: 70), hsa-miR-1280_st (SEQ ID NO: 402), hsa-miR-130b_st (SEQ ID NO: 403), hsa-miR-146b-3p_st (SEQ ID NO: 404), hsa-miR-146b-5p_st (SEQ ID NO: 405), hsa-miR-17-star_st (SEQ ID NO: 216), hsa-miR-185-star_st (SEQ ID NO: 406), hsa-miR-18a-star_st (SEQ ID NO: 71), hsa-miR-18a_st (SEQ ID NO: 72), hsa-miR-18b_st (SEQ ID NO: 87), hsa-miR-19a_st (SEQ ID NO: 217), hsa-miR-19b_st (SEQ ID NO: 153), hsa-miR-202_st (SEQ ID NO: 407), hsa-miR-20a_st (SEQ ID NO: 218), hsa-miR-20b_st (SEQ ID NO: 88), hsa-miR-223_st (SEQ ID NO: 131), hsa-miR-25-star_st (SEQ ID NO: 3), hsa-miR-373_st (SEQ ID NO: 408), hsa-miR-378-star_st (SEQ ID NO: 409), hsa-miR-422a_st (SEQ ID NO: 410), hsa-miR-423-5p_st (SEQ ID NO: 411), hsa-miR-451_st (SEQ ID NO: 412), hsa-miR-486-3p_st (SEQ ID NO: 413), hsa-miR-486-5p_st (SEQ ID NO: 414), hsa-miR-504_st (SEQ ID NO: 415), hsa-miR-550_st (SEQ ID NO: 416), hsa-miR-616_st (SEQ ID NO: 417), hsa-miR-671-3p_st (SEQ ID NO: 418), hsa-miR-671-5p_st (SEQ ID NO: 43), hsa-miR-766_st (SEQ ID NO: 1), hsa-miR-92a-1-star_st (SEQ ID NO: 192), hsa-miR-92a_st (SEQ ID NO: 156), and hsa-miR-93-star_st (SEQ ID NO: 45), wherein said device allows a determination of the sensitivity of said patient to carmustine; or xlvi) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from U41_st (SEQ ID NO: 394), hsa-miR-106b-star_st (SEQ ID NO: 2), hsa-miR-1183_st (SEQ ID NO: 126), hsa-miR-1207-5p_st (SEQ ID NO: 109), hsa-miR-1281_st (SEQ ID NO: 8), hsa-miR-18b_st (SEQ ID NO: 87), hsa-miR-195-star_st (SEQ ID NO: 14), hsa-miR-615-3p_st (SEQ ID NO: 419), hsa-miR-631_st (SEQ ID NO: 135), hsa-miR-766_st (SEQ ID NO: 1), and hsa-miR-92a-2-star_st (SEQ ID NO: 136), wherein said device allows a determination of the sensitivity of said patient to lomustine; or xlvii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from ACA43_st (SEQ ID NO: 420), ACA57_st (SEQ ID NO: 421), ENSG00000199411_s_st (SEQ ID NO: 422), ENSG00000200879_st (SEQ ID NO: 423), ENSG00000202252_st (SEQ ID NO: 424), HBII-142_st (SEQ ID NO: 293), HBII-142_x_st (SEQ ID NO: 425), HBII-202_st (SEQ ID NO: 426), HBII-429_st (SEQ ID NO: 427), U13_st (SEQ ID NO: 428), U25_st (SEQ ID NO: 429), U27_st (SEQ ID NO: 330), U29_st (SEQ ID NO: 430), U30_st (SEQ ID NO: 431), U31_x_st (SEQ ID NO: 190), U36C_st (SEQ ID NO: 335), U38A_st (SEQ ID NO: 432), U52_st (SEQ ID NO: 349), U55_st (SEQ ID NO: 433), U55_x_st (SEQ ID NO: 146), U59B_st (SEQ ID NO: 434), U74_x_st (SEQ ID NO: 377), U83B_st (SEQ ID NO: 400), U83_st (SEQ ID NO: 435), hsa-miR-106a_st (SEQ ID NO: 150), hsa-miR-1275_st (SEQ ID NO: 70), hsa-miR-17-star_st (SEQ ID NO: 216), hsa-miR-17_st (SEQ ID NO: 152), hsa-miR-18a-star_st (SEQ ID NO: 71), hsa-miR-18a_st (SEQ ID NO: 72), hsa-miR-18b_st (SEQ ID NO: 87), hsa-miR-19a_st (SEQ ID NO: 217), hsa-miR-19b_st (SEQ ID NO: 153), hsa-miR-20a_st (SEQ ID NO: 218), hsa-miR-20b_st (SEQ ID NO: 88), hsa-miR25-star_st (SEQ ID NO: 3), hsa-miR-378-star_st (SEQ ID NO: 409), hsa-miR-378_st (SEQ ID NO: 368), hsa-miR-422a_st (SEQ ID NO: 410), hsa-miR-423-5p_st (SEQ ID NO: 411), hsa-miR-663b_st (SEQ ID NO: 155), hsa-miR-766_st (SEQ ID NO: 1), hsa-miR-92a-1-star_st (SEQ ID NO: 192), and hsa-miR-92a_st (SEQ ID NO: 156), wherein said device allows a determination of the sensitivity of said patient to mercaptopurine; or xlviii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from ACA48_x_st (SEQ ID NO: 436), ACA7_s_st (SEQ ID NO: 437), HBII-239_st (SEQ ID NO: 438), HBII-429_st (SEQ ID NO: 55), HBII-85-26_st (SEQ ID NO: 439), U104_st (SEQ ID NO: 140), U17b_st (SEQ ID NO: 58), U17b_x_st (SEQ ID NO: 328), U55_st (SEQ ID NO: 308), U55_x_st (SEQ ID NO: 280), hsa-miR-106b-star_st (SEQ ID NO: 2), hsa-miR-124_st (SEQ ID NO: 7), hsa-miR-1281_st (SEQ ID NO: 8), hsa-miR-1299_st (SEQ ID NO: 38), hsa-miR-140-3p_st (SEQ ID NO: 13), hsa-miR-142-5p_st (SEQ ID NO: 215), hsa-miR-181a-star_st (SEQ ID NO: 9), hsa-miR-181a_st (SEQ ID NO: 78), hsa-miR-181b_st (SEQ ID NO: 10), hsa-miR-181c_st (SEQ ID NO: 79), hsa-miR-195-star_st (SEQ ID NO: 14), hsa-miR-297_st (SEQ ID NO: 132), hsa-miR-29b-2-star_st (SEQ ID NO: 39), hsa-miR-33b-star_st (SEQ ID NO: 40), hsa-miR-34b_st (SEQ ID NO: 154), hsa-miR-629-star_st (SEQ ID NO: 41), hsa-miR-766_st (SEQ ID NO: 1), hsa-miR-768-3p_st (SEQ ID NO: 44), hsa-miR-768-5p_st (SEQ ID NO: 83), and hsa-miR-92b_st (SEQ ID NO: 15), wherein said device allows a determination of the sensitivity of said patient to teniposide; or xlix) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-106b-star_st (SEQ ID NO: 2), hsa-miR-106b_st (SEQ ID NO: 37), hsa-miR-1275_st (SEQ ID NO: 70), hsa-miR-25-star_st (SEQ ID NO: 3), hsa-miR-25_st (SEQ ID NO: 89), hsa-miR-33b-star_st (SEQ ID NO: 40), hsa-miR-362-5p_st (SEQ ID NO: 92), hsa-miR-500-star_st (SEQ ID NO: 93), hsa-miR-500_st (SEQ ID NO: 94), hsa-miR-501-5p_st (SEQ ID NO: 304), hsa-miR-502-3p_st (SEQ ID NO: 96), hsa-miR-532-5p_st (SEQ ID NO: 98), hsa-miR-629-star_st (SEQ ID NO: 41), hsa-miR-629_st (SEQ ID NO: 440), hsa-miR-652_st (SEQ ID NO: 42), hsa-miR-671-5p_st (SEQ ID NO: 43), hsa-miR-766_st (SEQ ID NO: 1), hsa-miR-93-star_st (SEQ ID NO: 45), and hsa-miR-93_st (SEQ ID NO: 46), wherein said device allows a determination of the sensitivity of said patient to dactinomycin; or l) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from HBII-142_st (SEQ ID NO: 278), HBII-142_x_st (SEQ ID NO: 279), U55_st (SEQ ID NO: 6), U55_x_st (SEQ ID NO: 280), hsa-miR-1202_st (SEQ ID NO: 281), hsa-miR-124_st (SEQ ID NO: 7), hsa-miR-148a-star_st (SEQ ID NO: 282), hsa-miR-148a_st (SEQ ID NO: 275), hsa-miR-184_st (SEQ ID NO: 283), hsa-miR-191_st (SEQ ID NO: 284), hsa-miR-195-star_st (SEQ ID NO: 14), hsa-miR-29b-2-star_st (SEQ ID NO: 39), hsa-miR-425-star_st (SEQ ID NO: 285), hsa-miR-425_st (SEQ ID NO: 286), hsa-miR-449a_st (SEQ ID NO: 287), hsa-miR-449b_st (SEQ ID NO: 288), hsa-miR-551b_st (SEQ ID NO: 289), hsa-miR-593-star_st (SEQ ID NO: 290), hsa-miR-768-3p_st (SEQ ID NO: 44), hsa-miR-768-5p_st (SEQ ID NO: 83), and hsa-miR-877_st (SEQ ID NO: 291), wherein said device allows a determination of the sensitivity of said patient to tretinoin; or li) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from U17b_st (SEQ ID NO: 254), U48_st (SEQ ID NO: 441), U49B_s_st (SEQ ID NO: 442), U55_st (SEQ ID NO: 209), hsa-miR-1207-5p_st (SEQ ID NO: 109), hsa-miR-128_st (SEQ ID NO: 110), hsa-miR-181a-star_st (SEQ ID NO: 9), hsa-miR-181c-star_st (SEQ ID NO: 443), hsa-miR-181d_st (SEQ ID NO: 321), hsa-miR-20b-star_st (SEQ ID NO: 130), hsa-miR-20b_st (SEQ ID NO: 88), hsa-miR-223_st (SEQ ID NO: 131), hsa-miR-363_st (SEQ ID NO: 133), and hsa-miR-766_st (SEQ ID NO: 1), wherein said device allows a determination of the sensitivity of said patient to ifosfamide; or lii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from ACA10_s_st (SEQ ID NO: 444), ACA15_s_st (SEQ ID NO: 445), ACA43_st (SEQ ID NO: 446), ACA44_st (SEQ ID NO: 447), ACA51_x_st (SEQ ID NO: 324), ACA57_st (SEQ ID NO: 448), ENSG00000202252_st (SEQ ID NO: 449), HBII-142_st (SEQ ID NO: 450), HBII-142_x_st (SEQ ID NO: 425), HBII-180A_x_st (SEQ ID NO: 54), HBII-180C_st (SEQ ID NO: 451), HBII-180C_x_st (SEQ ID NO: 452), HBII-202_st (SEQ ID NO: 198), HBII-429_st (SEQ ID NO: 388), HBII-55_st (SEQ ID NO: 453), U104_st (SEQ ID NO: 56), U17a_st (SEQ ID NO: 454), U17a_x_st (SEQ ID NO: 455), U17b_st (SEQ ID NO: 456), U17b_x_st (SEQ ID NO: 457), U32A_x_st (SEQ ID NO: 458), U33_st (SEQ ID NO: 459), U34_st (SEQ ID NO: 256), U35A_st (SEQ ID NO: 460), U38A_st (SEQ ID NO: 461), U43_st (SEQ ID NO: 462), U43_x_st (SEQ ID NO: 462), U46_x_st (SEQ ID NO: 463), U52_st (SEQ ID NO: 258), U55_st (SEQ ID NO: 209), U55_x_st (SEQ ID NO: 146), U56_st (SEQ ID NO: 464), U56_x_st (SEQ ID NO: 211), U59B_st (SEQ ID NO: 465), U68_st (SEQ ID NO: 466), U70_x_st (SEQ ID NO: 398), U71d_st (SEQ ID NO: 467), U71d_x_st (SEQ ID NO: 468), U74_x_st (SEQ ID NO: 191), U83B_st (SEQ ID NO: 469), hsa-miR-106a_st (SEQ ID NO: 150), hsa-miR-106b-star_st (SEQ ID NO: 2), hsa-miR-106b_st (SEQ ID NO: 37), hsa-miR-1183_st (SEQ ID NO: 126), hsa-miR-1228_st (SEQ ID NO: 84), hsa-miR-1246_st (SEQ ID NO: 214), hsa-miR-1281_st (SEQ ID NO: 8), hsa-miR-149-star_st (SEQ ID NO: 359), hsa-miR-17-star_st (SEQ ID NO: 216), hsa-miR-17_st (SEQ ID NO: 152), hsa-miR-18a-star_st (SEQ ID NO: 71), hsa-miR-18a_st (SEQ ID NO: 72), hsa-miR-195-star_st (SEQ ID NO: 14), hsa-miR-19a_st (SEQ ID NO: 217), hsa-miR-19b_st (SEQ ID NO: 153), hsa-miR-20a_st (SEQ ID NO: 218), hsa-miR-25-star_st (SEQ ID NO: 3), hsa-miR-297_st (SEQ ID NO: 132), hsa-miR-34b_st (SEQ ID NO: 154), hsa-miR-593-star_st (SEQ ID NO: 290), hsa-miR-629-star_st (SEQ ID NO: 41), hsa-miR-652_st (SEQ ID NO: 42), hsa-miR-671-5p_st (SEQ ID NO: 43), hsa-miR-769-5p_st (SEQ ID NO: 105), hsa-miR-92a_st (SEQ ID NO: 156), hsa-miR-93-star_st (SEQ ID NO: 45), and hsa-miR-93_st (SEQ ID NO: 46), wherein said device allows a determination of the sensitivity of said patient to tamoxifen; or liii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-181a-star_st (SEQ ID NO: 9), hsa-miR-297_st (SEQ ID NO: 132), hsa-miR-432_st (SEQ ID NO: 12), hsa-miR-766_st (SEQ ID NO: 1), and hsa-miR-874_st (SEQ ID NO: 310), wherein said device allows a determination of the sensitivity of said patient to irinotecan; or liv) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from HBII-202_st (SEQ ID NO: 239), HBII-85-11_st (SEQ ID NO: 470), U104_st (SEQ ID NO: 471), and U13_st (SEQ ID NO: 472), wherein said device allows a determination of the sensitivity of said patient to floxuridine; or lv) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from ACA13_st (SEQ ID NO: 473), ENSG00000202093_x_st (SEQ ID NO: 474), ENSG00000202252_st (SEQ ID NO: 244), HBII-202_st (SEQ ID NO: 198), HBII-429_st (SEQ ID NO: 475), HBII-55_st (SEQ ID NO: 476), U104_st (SEQ ID NO: 116), U13_st (SEQ ID NO: 477), U17b_st (SEQ ID NO: 456), U17b_x_st (SEQ ID NO: 59), U25_st (SEQ ID NO: 478), U27_st (SEQ ID NO: 330), U29_st (SEQ ID NO: 203), U30_st (SEQ ID NO: 479), U31_st (SEQ ID NO: 142), U31_x_st (SEQ ID NO: 205), U36A_st (SEQ ID NO: 480), U36C_st (SEQ ID NO: 481), U38A_st (SEQ ID NO: 348), U52_st (SEQ ID NO: 258), U54_st (SEQ ID NO: 482), U55_st (SEQ ID NO: 208), U55_x_st (SEQ ID NO: 280), U56_x_st (SEQ ID NO: 210), U74_x_st (SEQ ID NO: 264), U75_st (SEQ ID NO: 483), U78_s_st (SEQ ID NO: 484), U78_x_st (SEQ ID NO: 228), U83B_st (SEQ ID NO: 485), U83_st (SEQ ID NO: 486), U95_st (SEQ ID NO: 487), hsa-miR-106a_st (SEQ ID NO: 150), hsa-miR-1183_st (SEQ ID NO: 126), hsa-miR-1246_st (SEQ ID NO: 214), hsa-miR-1281_st (SEQ ID NO: 8), hsa-miR-142-5p_st (SEQ ID NO: 215), hsa-miR-17-star_st (SEQ ID NO: 216), hsa-miR-17_st (SEQ ID NO: 152), hsa-miR-18a-star_st (SEQ ID NO: 71), hsa-miR-18a_st (SEQ ID NO: 72), hsa-miR-18b_st (SEQ ID NO: 87), hsa-miR-19a_st (SEQ ID NO: 217), hsa-miR-19b_st (SEQ ID NO: 153), hsa-miR-20a_st (SEQ ID NO: 218), hsa-miR-297_st (SEQ ID NO: 132), hsa-miR-34b_st (SEQ ID NO: 154), hsa-miR-378-star_st (SEQ ID NO: 409), hsa-miR-378_st (SEQ ID NO: 368), hsa-miR-491-3p_st (SEQ ID NO: 351), hsa-miR-766_st (SEQ ID NO: 1), hsa-miR-92a-1-star_st (SEQ ID NO: 192), and hsa-miR-92a_st (SEQ ID NO: 156), wherein said device allows a determination of the sensitivity of said patient to thioguanine; or lvi) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from ACA18_x_st (SEQ ID NO: 48), ACA9_st (SEQ ID NO: 373), ENSG00000202252_st (SEQ ID NO: 488), HBII-180A_x_st (SEQ ID NO: 54), HBII-180B_x_st (SEQ ID NO: 489), HBII-180C_st (SEQ ID NO: 490), HBII-180C_x_st (SEQ ID NO: 491), HBII-382_s_st (SEQ ID NO: 492), U3-2_s_st (SEQ ID NO: 493), U34_st (SEQ ID NO: 355), U38B_st (SEQ ID NO: 494), U50B_x_st (SEQ ID NO: 495), U56_st (SEQ ID NO: 496), U59B_st (SEQ ID NO: 497), U68_x_st (SEQ ID NO: 498), hsa-miR-106a_st (SEQ ID NO: 150), hsa-miR-1281_st (SEQ ID NO: 8), hsa-miR-1292_st (SEQ ID NO: 499), hsa-miR-1307_st (SEQ ID NO: 102), hsa-miR-17-star_st (SEQ ID NO: 216), hsa-miR-17_st (SEQ ID NO: 152), hsa-miR-18a-star_st (SEQ ID NO: 71), hsa-miR-18a_st (SEQ ID NO: 72), hsa-miR-18b_st (SEQ ID NO: 87), hsa-miR-19b_st (SEQ ID NO: 153), hsa-miR-20a_st (SEQ ID NO: 218), hsa-miR-25-star_st (SEQ ID NO: 3), hsa-miR-378-star_st (SEQ ID NO: 409), hsa-miR-378_st (SEQ ID NO: 368), hsa-miR-422a_st (SEQ ID NO: 410), hsa-miR-92a-1-star_st (SEQ ID NO: 192), hsa-miR-92a_st (SEQ ID NO: 156), and hsa-miR-93-star_st (SEQ ID NO: 45), wherein said device allows a determination of the sensitivity of said patient to PSC 833; or lvii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-130a_st (SEQ ID NO: 313), hsa-miR-149_st (SEQ ID NO: 500), hsa-miR-193a-3p_st (SEQ ID NO: 366), hsa-miR-27a_st (SEQ ID NO: 501), hsa-miR-30a-star_st (SEQ ID NO: 502), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-30c-2-star_st (SEQ ID NO: 504), hsa-miR-30c_st (SEQ ID NO: 301), and hsa-miR-30e-star_st (SEQ ID NO: 505), wherein said device allows a determination of the sensitivity of said patient to erlotinib; or lviii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-34c-3p_st (SEQ ID NO: 314), hsa-miR-34c-5p_st (SEQ ID NO: 506), and hsa-miR-489_st (SEQ ID NO: 298), wherein said device allows a determination of the sensitivity of said patient to herceptin; or lix) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from ACA18_x_st (SEQ ID NO: 139), ACA51_x_st (SEQ ID NO: 507), HBII-142_st (SEQ ID NOs: 293), HBII-142_x_st (SEQ ID NO: 508), HBII-180A_x_st (SEQ ID NO: 386), HBII-180C_x_st (SEQ ID NO: 451), U68_x_st (SEQ ID NO: 67), U70_x_st (SEQ ID NO: 509), hsa-miR-1207-5p_st (SEQ ID NO: 109), hsa-miR-1268_st (SEQ ID NO: 127), and hsa-miR-768-3p_st (SEQ ID NO: 44), wherein said device allows a determination of the sensitivity of said patient to celecoxib; or lx) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from U104_st (SEQ ID NO: 116), hsa-miR-1202_st (SEQ ID NO: 281), hsa-miR-1226_st (SEQ ID NO: 365), hsa-miR-15b_st (SEQ ID NO: 510), hsa-miR-191_st (SEQ ID NO: 284), hsa-miR-203_st (SEQ ID NO: 511), hsa-miR-25_st (SEQ ID NO: 89), hsa-miR-29b-2-star_st (SEQ ID NO: 39), hsa-miR-301a_st (SEQ ID NO: 342), hsa-miR-339-5p_st (SEQ ID NO: 273), hsa-miR-342-5p_st (SEQ ID NO: 80), hsa-miR-421_st (SEQ ID NO: 512), hsa-miR-425-star_st (SEQ ID NO: 285), hsa-miR-425_st (SEQ ID NO: 286), hsa-miR-449b_st (SEQ ID NO: 288), hsa-miR-489_st (SEQ ID NO: 298), hsa-miR-492_st (SEQ ID NO: 513), hsa-miR-622_st (SEQ ID NO: 514), hsa-miR-768-3p_st (SEQ ID NO: 44), and hsa-miR-768-5p_st (SEQ ID NO: 83), wherein said device allows a determination of the sensitivity of said patient to fulvestrant; or lxi) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-1826_st (SEQ ID NO: 515), hsa-miR-205_st (SEQ ID NO: 295), hsa-miR-30c_st (SEQ ID NO: 301), hsa-miR-675_st (SEQ ID NO: 516), and hsa-miR-934_st (SEQ ID NO: 517), wherein said device allows a determination of the sensitivity of said patient to iressa; or lxii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-1323_st (SEQ ID NO: 518), hsa-miR-184_st (SEQ ID NO: 283), hsa-miR-187_st (SEQ ID NO: 519), hsa-miR-197_st (SEQ ID NO: 520), hsa-miR-498_st (SEQ ID NO: 521), hsa-miR-504_st (SEQ ID NO: 415), hsa-miR-506_st (SEQ ID NO: 21), hsa-miR-508-5p_st (SEQ ID NO: 22), hsa-miR-509-3-5p_st (SEQ ID NO: 23), hsa-miR-509-3p_st (SEQ ID NO: 24), hsa-miR-509-5p_st (SEQ ID NO: 522), hsa-miR-510_st (SEQ ID NO: 25), hsa-miR-512-3p_st (SEQ ID NO: 523), hsa-miR-513a-5p_st (SEQ ID NO: 26), hsa-miR-513b_st (SEQ ID NO: 27), hsa-miR-513c_st (SEQ ID NO: 524), hsa-miR-516b_st (SEQ ID NO: 525), hsa-miR-517a_st (SEQ ID NO: 526), hsa-miR-517b_st (SEQ ID NO: 527), hsa-miR-525-5p_st (SEQ ID NO: 528), hsa-miR-526b_st (SEQ ID NO: 529), hsa-miR-551a_st (SEQ ID NO: 530), hsa-miR-873_st (SEQ ID NO: 531), and hsa-miR-891a_st (SEQ ID NO: 532), wherein said device allows a determination of the sensitivity of said patient to anastrozole; or lxiii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-1323_st (SEQ ID NO: 518), hsa-miR-361-5p_st (SEQ ID NO: 533), hsa-miR-498_st (SEQ ID NO: 521), hsa-miR-512-3p_st (SEQ ID NO: 523), hsa-miR-516b_st (SEQ ID NO: 525), hsa-miR-517a_st (SEQ ID NO: 526), hsa-miR-525-5p_st (SEQ ID NO: 528), hsa-miR-551a_st (SEQ ID NO: 530), and hsa-miR-873_st (SEQ ID NO: 531), wherein said device allows a determination of the sensitivity of said patient to letrozole; or lxiv) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7i-star_st (SEQ ID NO: 232), hsa-miR-338-3p_st (SEQ ID NO: 233), and hsa-miR-34a_st (SEQ ID NO: 234), wherein said device allows a determination of the sensitivity of said patient to radiation; or lxv) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-1826_st (SEQ ID NO: 515), hsa-miR-30c-2-star_st (SEQ ID NO: 504), hsa-miR-34b-star_st (SEQ ID NO: 534), hsa-miR-34c-3p_st (SEQ ID NO: 314), hsa-miR-34c-5p_st (SEQ ID NO: 506), and hsa-miR-489_st (SEQ ID NO: 298), wherein said device allows a determination of the sensitivity of said patient to cetuximab. 8. The method of claim 5, wherein said device comprises two or more of said single-stranded nucleic acid molecules of i) to lxv). 9. The method of claim 2, wherein said device comprises: i) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from HBII-85-29_st (SEQ ID NO: 535), hsa-miR-130a_st (SEQ ID NO: 313), hsa-miR-148b_st (SEQ ID NO: 536), hsa-miR-184_st (SEQ ID NO: 283), hsa-miR-26a_st (SEQ ID NO: 537), hsa-miR-30a-star_st (SEQ ID NO: 502), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-30c-2-star_st (SEQ ID NO: 504), hsa-miR-30c_st (SEQ ID NO: 301), hsa-miR-34a-star_st (SEQ ID NO: 277), hsa-miR-34a_st (SEQ ID NO: 234), hsa-miR-34c-5p_st (SEQ ID NO: 506), hsa-miR-449a_st (SEQ ID NO: 287), and hsa-miR-449b_st (SEQ ID NO: 288), wherein said device allows a determination of the resistance of said patient to vincristine; or ii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-10a_st (SEQ ID NO: 538), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p st (SEQ ID NO: 540), hsa-miR-192-star_st (SEQ ID NO: 541), hsa-miR-192_st (SEQ ID NO: 542), hsa-miR-194_st (SEQ ID NO: 543), hsa-miR-200b_st (SEQ ID NO: 544), hsa-miR-203_st (SEQ ID NO: 511), hsa-miR-29b_st (SEQ ID NO: 545), hsa-miR-30b_st (SEQ ID NO: 546), hsa-miR-30d_st (SEQ ID NO: 547), and hsa-miR-625_st (SEQ ID NO: 548), wherein said device allows a determination of the resistance of said patient to cisplatin; or iii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-10b_st (SEQ ID NO: 550), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-141_st (SEQ ID NO: 552), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-200a-star_st (SEQ ID NO: 553), hsa-miR-200a_st (SEQ ID NO: 554), hsa-miR-200b-star_st (SEQ ID NO: 555), hsa-miR-200b_st (SEQ ID NO: 544), hsa-miR-200c_st (SEQ ID NO: 556), hsa-miR-203_st (SEQ ID NO: 511), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-30b_st (SEQ ID NO: 546), hsa-miR-30c_st (SEQ ID NO: 301), hsa-miR-30d_st (SEQ ID NO: 547), hsa-miR-429_st (SEQ ID NO: 557), hsa-miR-516a-5p_st (SEQ ID NO: 558), hsa-miR-934_st (SEQ ID NO: 517), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to etoposide; or iv) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-1244_st (SEQ ID NO: 560), hsa-miR-1303_st (SEQ ID NO: 561), hsa-miR-141-star_st (SEQ ID NO: 562), hsa-miR-141_st (SEQ ID NO: 552), hsa-miR-182_st (SEQ ID NO: 563), hsa-miR-183-star_st (SEQ ID NO: 564), hsa-miR-183_st (SEQ ID NO: 565), hsa-miR-192-star_st (SEQ ID NO: 541), hsa-miR-192_st (SEQ ID NO: 542), hsa-miR-194_st (SEQ ID NO: 543), hsa-miR-200a-star_st (SEQ ID NO:553), hsa-miR-200a_st (SEQ ID NO: 554), hsa-miR-200b-star_st (SEQ ID NO:555), hsa-miR-200b_st (SEQ ID NO:544), hsa-miR-200c-star_st (SEQ ID NO: 231), hsa-miR-200c_st (SEQ ID NO: 556), hsa-miR-203_st (SEQ ID NO: 511), hsa-miR-205_st (SEQ ID NO:295), hsa-miR-215_st (SEQ ID NO: 566), hsa-miR-27b_st (SEQ ID NO: 567), hsa-miR-331-3p_st (SEQ ID NO: 568), hsa-miR-375_st (SEQ ID NO: 297), hsa-miR-429_st (SEQ ID NO: 557), hsa-miR-622_st (SEQ ID NO: 514), hsa-miR-934_st (SEQ ID NO: 517), and hsa-miR-99b-star_st (SEQ ID NO: 569), wherein said device allows a determination of the resistance of said patient to azaguanine; or v) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-10a_st (SEQ ID NO: 538), hsa-miR-183_st (SEQ ID NO: 565), hsa-miR-192-star_st (SEQ ID NO: 541), hsa-miR-192_st (SEQ ID NO: 542), hsa-miR-194_st (SEQ ID NO: 543), hsa-miR-200a-star_st (SEQ ID NO: 553), hsa-miR-200a_st (SEQ ID NO: 554), hsa-miR-200b-star_st (SEQ ID NO:555), hsa-miR-200b_st (SEQ ID NO: 544), hsa-miR-200c-star_st (SEQ ID NO: 231), hsa-miR-203_st (SEQ ID NO: 511), hsa-miR-29b_st (SEQ ID NO: 545), hsa-miR-30b_st (SEQ ID NO: 546), hsa-miR-30d_st (SEQ ID NO: 547), hsa-miR-429_st (SEQ ID NO: 557), hsa-miR-625_st (SEQ ID NO: 548), and hsa-miR-7_st (SEQ ID NO: 570), wherein said device allows a determination of the resistance of said patient to carboplatin; or vi) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-203_st (SEQ ID NO: 511), hsa-miR-23a_st (SEQ ID NO: 571), hsa-miR-29b_st (SEQ ID NO: 545), hsa-miR-30a_st (SEQ ID NO:503), hsa-miR-30c_st (SEQ ID NO: 301), hsa-miR-516a-5p_st (SEQ ID NO: 558), hsa-miR-518d-5p_st (SEQ ID NO: 572), hsa-miR-518e-star_st (SEQ ID NO: 573), hsa-miR-519a-star_st (SEQ ID NO: 573), hsa-miR-519a_st (SEQ ID NO: 574), hsa-miR-519b-5p_st (SEQ ID NO: 573), hsa-miR-519c-5p_st (SEQ ID NO: 573), hsa-miR-522-star_st (SEQ ID NO: 573), hsa-miR-523-star_st (SEQ ID NO: 573), hsa-miR-526a_st (SEQ ID NO: 572), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to adriamycin; or vii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7a_st (SEQ ID NO: 575), hsa-let-7c_st (SEQ ID NO: 576), hsa-let-7e_st (SEQ ID NO: 549), hsa-let-7f_st (SEQ ID NO: 577), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-193a-5p_st (SEQ ID NO: 165), hsa-miR-22-star_st (SEQ ID NO: 578), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-23a_st (SEQ ID NO: 571), hsa-miR-24-2-star_st (SEQ ID NO: 579), hsa-miR-24_st (SEQ ID NO: 580), hsa-miR-30a_st (SEQ ID NO: 503), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to aclarubicin; or viii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-29b_st (SEQ ID NO: 545), hsa-miR-30b_st (SEQ ID NO: 546), hsa-miR-30d_st (SEQ ID NO: 547), hsa-miR-506_st (SEQ ID NO: 21), hsa-miR-508-5p_st (SEQ ID NO: 22), hsa-miR-509-3-5p_st (SEQ ID NO: 23), hsa-miR-509-3p_st (SEQ ID NO: 24), hsa-miR-509-5p_st (SEQ ID NO: 522), hsa-miR-510_st (SEQ ID NO: 25), hsa-miR-513a-5p_st (SEQ ID NO: 26), hsa-miR-513c_st (SEQ ID NO: 524), hsa-miR-516a-5p_st (SEQ ID NO: 558), hsa-miR-584_st (SEQ ID NO: 581), and hsa-miR-885-3p_st (SEQ ID NO: 582), wherein said device allows a determination of the resistance of said patient to mitoxantrone; or ix) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-516a-5p_st (SEQ ID NO: 558) and hsa-miR-526a_st (SEQ ID NO: 572), wherein said device allows a determination of the resistance of said patient to mitomycin; or x) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from HBII-85-29_st (SEQ ID NO: 535), hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-130a_st (SEQ ID NO: 313), hsa-miR-193b_st (SEQ ID NO: 583), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-27a_st (SEQ ID NO: 501), hsa-miR-29a_st (SEQ ID NO: 584), hsa-miR-29b_st (SEQ ID NO: 545), hsa-miR-30a-star_st (SEQ ID NO: 502), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-30c-2-star_st (SEQ ID NO: 504), hsa-miR-30c_st (SEQ ID NO: 301), hsa-miR-34a_st (SEQ ID NO: 234), hsa-miR-34b-star_st (SEQ ID NO 534), hsa-miR-34c-3p_st (SEQ ID NO: 314), and hsa-miR-34c-5p_st (SEQ ID NO: 506), wherein said device allows a determination of the resistance of said patient to paclitaxel; or xi) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-141_st (SEQ ID NO: 552), hsa-miR-584_st (SEQ ID NO: 581), and hsa-miR-934_st (SEQ ID NO: 517), wherein said device allows a determination of the resistance of said patient to gemcitabine; or xii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from HBII-438A_s_st (SEQ ID NO: 585), HBII-85-11_st (SEQ ID NO: 249), HBII-85-15_x_st (SEQ ID NO: 586), HBII-85-23_x_st (SEQ ID NO: 587), HBII-85-29_st (SEQ ID NO: 588), HBII-85-29_x_st (SEQ ID NO: 589), hsa-miR-184_st (SEQ ID NO: 283), hsa-miR-29a_st (SEQ ID NO: 584), hsa-miR-29b_st (SEQ ID NO: 545), hsa-miR-34a_st (SEQ ID NO: 234), hsa-miR-34c-3p_st (SEQ ID NO: 314), hsa-miR-34c-5p_st (SEQ ID NO: 506), and hsa-miR-424-star_st (SEQ ID NO: 100), wherein said device allows a determination of the resistance of said patient to docetaxel; or xiii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-99b_st (SEQ ID NO: 559), hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-182_st (SEQ ID NO: 563), hsa-miR-23b_st (SEQ ID NO: 590), hsa-miR-24_st (SEQ ID NO: 580), and hsa-miR-34a_st (SEQ ID NO: 234), wherein said device allows a determination of the resistance of said patient to dexamethasone; or xiv) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-23b-star_st (SEQ ID NO: 591), hsa-miR-23b_st (SEQ ID NO: 590), hsa-miR-27b_st (SEQ ID NO: 567), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to Ara-C (cytarabine hydrochloride); or xv) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-1308_st (SEQ ID NO: 274), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-182_st (SEQ ID NO: 563), hsa-miR-193b_st (SEQ ID NO: 583), hsa-miR-21-star_st (SEQ ID NO: 166), hsa-miR-21_st (SEQ ID NO: 592), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-23a_st (SEQ ID NO: 571), hsa-miR-23b_st (SEQ ID NO: 590), hsa-miR-24-2-star_st (SEQ ID NO: 579), hsa-miR-24_st (SEQ ID NO: 580), hsa-miR-27a-star_st (SEQ ID NO: 593), hsa-miR-27a_st (SEQ ID NO: 501), hsa-miR-27b_st (SEQ ID NO: 567), hsa-miR-339-3p_st (SEQ ID NO: 272), hsa-miR-34a_st (SEQ ID NO: 234), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to methylprednisolone; or xvi) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-23b_st (SEQ ID NO: 590), hsa-miR-27b_st (SEQ ID NO: 567), hsa-miR-28-5p_st (SEQ ID NO: 594), hsa-miR-30a-star_st (SEQ ID NO: 502), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-34c-5p_st (SEQ ID NO: 506), hsa-miR-516b_st (SEQ ID NO: 525), hsa-miR-517a_st (SEQ ID NO: 526), and hsa-miR-525-5p_st (SEQ ID NO: 528), wherein said device allows a determination of the resistance of said patient to methotrexate; or xvii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-1244_st (SEQ ID NO: 560), hsa-miR-128_st (SEQ ID NO: 110), hsa-miR-1292_st (SEQ ID NO: 499), hsa-miR-141_st (SEQ ID NO: 552), hsa-miR-15b_st (SEQ ID NO: 510), hsa-miR-185-star_st (SEQ ID NO: 406), hsa-miR-188-5p_st (SEQ ID NO: 86), hsa-miR-18b_st (SEQ ID NO: 87), hsa-miR-200c_st (SEQ ID NO: 556), hsa-miR-203_st (SEQ ID NO: 511), hsa-miR-20b_st (SEQ ID NO: 88), hsa-miR-215_st (SEQ ID NO: 566), hsa-miR-25_st (SEQ ID NO: 89), hsa-miR-30b_st (SEQ ID NO: 546), hsa-miR-30d_st (SEQ ID NO: 547), hsa-miR-362-5p_st (SEQ ID NO: 92), hsa-miR-378-star_st (SEQ ID NO: 409), hsa-miR-421_st (SEQ ID NO: 512), hsa-miR-425_st (SEQ ID NO: 286), hsa-miR-532-5p_st (SEQ ID NO: 98), hsa-miR-93_st (SEQ ID NO: 46), and hsa-miR-941_st (SEQ ID NO: 595), wherein said device allows a determination of the resistance of said patient to bleomycin; or xviii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7e_st (SEQ ID NO: 549), hsa-let-7i_st (SEQ ID No: 596), hsa-miR-10a_it (SEQ ID NO: 538), hsa-miR-10b_st (SEQ ID NO: 550), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-1301_st (SEQ ID NO: 597), hsa-miR-140-5p_st (SEQ ID NO: 18), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to methyl-GAG (methyl glyoxal bis amidinohydrazone dihydrochloride); or xix) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from 14qII-14_st (SEQ ID NO: 598), 14qII-1_x_st (SEQ ID NO: 599), hsa-let-7b_st (SEQ ID NO: 600), hsa-let-7c_st (SEQ ID NO: 576), hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-10a_st (SEQ ID NO: 538), hsa-miR-10b_st (SEQ ID NO: 550), hsa-miR-125a-3p_st (SEQ ID NO: 601), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-125b-1-star_st (SEQ ID NO: 163), hsa-miR-125b_st (SEQ ID NO: 602), hsa-miR-1287_st (SEQ ID NO: 603), hsa-miR-134_st (SEQ ID NO: 164), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-23a-star_st (SEQ ID NO: 604), hsa-miR-23a_st (SEQ ID NO: 571), hsa-miR-23b_st (SEQ ID NO: 590), hsa-miR-24-2-star_st (SEQ ID NO: 579), hsa-miR-24_st (SEQ ID NO: 580), hsa-miR-27a_st (SEQ ID NO: 501), hsa-miR-27b_st (SEQ ID NO: 567), hsa-miR-28-3p_st (SEQ ID NO: 605), hsa-miR-28-5p_st (SEQ ID NO: 594), hsa-miR-299-5p_st (SEQ ID NO: 606), hsa-miR-337-5p_st (SEQ ID NO: 169), hsa-miR-370_st (SEQ ID NO: 32), hsa-miR-376a_st (SEQ ID No: 607), hsa-miR-376c_st (SEQ ID NO: 170), hsa-miR-379_st (SEQ ID NO: 172), hsa-miR-381_st (SEQ ID NO: 173), hsa-miR-382_st (SEQ ID NO: 174), hsa-miR-409-3p_st (SEQ ID NO: 81), hsa-miR-409-5p_st (SEQ ID NO: 175), hsa-miR-411_st (SEQ ID NO: 176), hsa-miR-431_st (SEQ ID NO: 177), hsa-miR-452_st (SEQ ID NO: 608), hsa-miR-485-5p_st (SEQ ID NO: 179), hsa-miR-487a_st (SEQ ID NO: 609), hsa-miR-487b_st (SEQ ID NO: 82), hsa-miR-494_st (SEQ ID NO: 181), hsa-miR-495_st (SEQ ID NO: 610), hsa-miR-543_st (SEQ ID NO: 182), hsa-miR-654-5p_st (SEQ ID NO: 611), hsa-miR-99b-star_st (SEQ ID NO: 569), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to belinostat (PXD101); or xx) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-100_st (SEQ ID NO: 17), hsa-miR-125b_st (SEQ ID NO: 602), hsa-miR-130a_st (SEQ ID NO: 313), hsa-miR-181a-2-star_st (SEQ ID NO: 612), hsa-miR-184_st (SEQ ID NO: 283), hsa-miR-197_st (SEQ ID NO: 520), hsa-miR-221-star_st (SEQ ID NO: 613), hsa-miR-30a-star_st (SEQ ID NO: 502), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-30c-2-star_st (SEQ ID NO: 504), hsa-miR-525-5p_st (SEQ ID NO: 528), and hsa-miR-584_st (SEQ ID NO: 581), wherein said device allows a determination of the resistance of said patient to 5-fluorouracil; or xxi) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-1207-5p_st (SEQ ID NO: 109), hsa-miR-625_st (SEQ ID NO: 548), and hsa-miR-766_st (SEQ ID NO: 1), wherein said device allows a determination of the resistance of said patient to; or xxii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-21_st (SEQ ID NO: 592), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-30a-star_st (SEQ ID NO: 502), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-30c-2-star_st (SEQ ID NO: 504), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to 5-Aza-2'-deoxycytidine (decitabine); or xxiii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-221-star_st (SEQ ID NO: 613), hsa-miR-23a_st (SEQ ID NO: 571), hsa-miR-24-2-star_st (SEQ ID NO: 579), hsa-miR-24_st (SEQ ID NO: 580), hsa-miR-30b_st (SEQ ID NO: 546), hsa-miR-30d_st (SEQ ID NO: 547), hsa-miR-526a_st (SEQ ID NO: 572), hsa-miR-584_st (SEQ ID NO: 581), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to idarubicin; or xxiv) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-10a_st (SEQ ID NO: 538), hsa-miR-125a-3p_st (SEQ ID NO: 601), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-182_st (SEQ ID NO: 563), hsa-miR-183-star_st (SEQ ID NO: 564), hsa-miR-183_st (SEQ ID NO: 565), hsa-miR-193b_st (SEQ ID NO: 583), hsa-miR-200b-star_st (SEQ ID NO: 555), hsa-miR-200b_st (SEQ ID NO: 544), hsa-miR-21_st (SEQ ID NO: 592), hsa-miR-221-star_st (SEQ ID NO: 613), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-23a_st (SEQ ID NO: 571), hsa-miR-23b_st (SEQ ID NO: 590), hsa-miR-24_st (SEQ ID NO: 580), hsa-miR-27b_st (SEQ ID NO: 567), hsa-miR-29b_st (SEQ ID NO: 545), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-30d_st (SEQ ID NO: 547), hsa-miR-31-star_st (SEQ ID NO: 614), hsa-miR-31_st (SEQ ID NO: 615), hsa-miR-320d_st (SEQ ID NO: 91), hsa-miR-584_st (SEQ ID NO: 581), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to melphalan; or xxv) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7a_st (SEQ ID NO: 575), hsa-miR-100_st (SEQ ID NO: 17), and hsa-miR-146a_st (SEQ ID NO: 19), wherein said device allows a determination of the resistance of said patient to IL4-PR38 fusion protein; or xxvi) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from HBII-85-26_st (SEQ ID NO: 439), HBII-85-6_x_st (SEQ ID NO: 616), hsa-miR-491-5p_st (SEQ ID NO: 617), hsa-miR-589-star_st (SEQ ID NO: 618), hsa-miR-625_st (SEQ ID NO: 548), and hsa-miR-744_st (SEQ ID NO: 619), wherein said device allows a determination of the resistance of said patient to valproic acid; or xxvii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7b_st (SEQ ID NO: 600), hsa-let-7e_st (SEQ ID NO: 549), hsa-let-7i_st (SEQ ID NO: 596), hsa-miR-10a_st (SEQ ID NO: 538), hsa-miR-10b_st (SEQ ID NO: 550), hsa-miR-125a-3p_st (SEQ ID NO: 601), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-181a-2-star_st (SEQ ID NO: 612), hsa-miR-21-star_st (SEQ ID NO: 166), hsa-miR-21_st (SEQ ID NO: 592), hsa-miR-221_st (SEQ ID NO: 620), hsa-miR-222_st (SEQ ID NO: 621), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-28-3p_st (SEQ ID NO: 605), hsa-miR-28-5p_st (SEQ ID NO: 594), hsa-miR-29b-1-star_st (SEQ ID NO: 622), hsa-miR-30a-star_st (SEQ ID NO: 502), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-30c-2-star_st (SEQ ID NO: 504), hsa-miR-455-3p_st (SEQ ID NO: 178), hsa-miR-99b-star_st (SEQ ID NO: 569), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to all-trans retinoic acid (ATRA); or xxviii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7b_st (SEQ ID NO: 600), hsa-let-7d_st (SEQ ID NO: 623), hsa-let-7g_st (SEQ ID NO: 624), hsa-let-7i_st (SEQ ID NO: 596), hsa-miR-100_st (SEQ ID NO: 17), hsa-miR-138_st (SEQ ID NO: 625), hsa-miR-221_st (SEQ ID NO: 620), hsa-miR-222_st (SEQ ID NO: 621), hsa-miR-27a-star_st (SEQ ID NO: 593), hsa-miR-29a_st (SEQ ID NO: 584), hsa-miR-31_st (SEQ ID NO: 615), hsa-miR-503_st (SEQ ID NO: 101), and hsa-miR-625_st (SEQ ID NO: 548), wherein said device allows a determination of the resistance of said patient to cytoxan; or xxix) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from HBII-289_st (SEQ ID NO: 626), hsa-miR-141_st (SEQ ID NO: 552), hsa-miR-373_st (SEQ ID NO: 408), hsa-miR-512-3p_st (SEQ ID NO: 523), hsa-miR-517a_st (SEQ ID NO: 526), hsa-miR-525-5p_st (SEQ ID NO: 528), hsa-miR-584_st (SEQ ID NO: 581), and hsa-miR-934_st (SEQ ID NO: 517), wherein said device allows a determination of the resistance of said patient to topotecan; or xxx) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from 14qII-14_st (SEQ ID NO: 627), 14qII-14_x_st (SEQ ID NO: 73), 14qII-1_x_st (SEQ ID NO: 628), 14qII-26_st (SEQ ID No: 629), 14qII-26_x_st (SEQ ID NO: 630), hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-125a-3p_st (SEQ ID NO: 601), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-125b-1-star_st (SEQ ID NO: 163), hsa-miR-127-3p_st (SEQ ID NO: 77), hsa-miR-127-5p_st (SEQ ID NO: 631), hsa-miR-134_st (SEQ ID NO: 164), hsa-miR-143-star_st (SEQ ID NO: 632), hsa-miR-143_st (SEQ ID NO: 31), hsa-miR-193a-3p_st (SEQ ID NO: 366), hsa-miR-193a-5p_st (SEQ ID NO: 165), hsa-miR-193b-star_st (SEQ ID NO: 633), hsa-miR-199a-5p_st (SEQ ID NO: 634), hsa-miR-21-star_st (SEQ ID NO: 166), hsa-miR-210_st (SEQ ID NO: 635), hsa-miR-214_st (SEQ ID NO: 636), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-23a-star_st (SEQ ID NO: 604), hsa-miR-23b-star_st (SEQ ID NO: 591), hsa-miR-23b_st (SEQ ID NO: 590), hsa-miR-24-2-star_st (SEQ ID NO: 579), hsa-miR-24_st (SEQ ID NO: 580), hsa-miR-27a-star_st (SEQ ID NO: 593), hsa-miR-27a_st (SEQ ID NO: 501), hsa-miR-27b_st (SEQ ID NO: 567), hsa-miR-28-3p_st (SEQ ID NO: 605), hsa-miR-299-3p_st (SEQ ID NO: 168), hsa-miR-337-5p_st (SEQ ID NO: 169), hsa-miR-339-3p_st (SEQ ID NO: 272), hsa-miR-339-5p_st (SEQ ID NO: 273), hsa-miR-370_st (SEQ ID NO: 32), hsa-miR-376c_st (SEQ ID NO: 170), hsa-miR-377-star_st (SEQ ID NO: 171), hsa-miR-379_st (SEQ ID NO: 172), hsa-miR-381_st (SEQ ID NO: 173), hsa-miR-409-3p_st (SEQ ID NO: 81), hsa-miR-409-5p_st (SEQ ID NO: 175), hsa-miR-410_st (SEQ ID NO: 637), hsa-miR-411_st (SEQ ID NO: 176), hsa-miR-431_st (SEQ ID NO: 177), hsa-miR-455-3p_st (SEQ ID NO: 178), hsa-miR-485-5p_st (SEQ ID NO: 179), hsa-miR-487a_st (SEQ ID NO: 609), hsa-miR-487b_st (SEQ ID NO: 82), hsa-miR-491-5p_st (SEQ ID NO: 617), hsa-miR-493_st (SEQ ID NO: 180), hsa-miR-494_st (SEQ ID NO: 181), hsa-miR-542-5p_st (SEQ ID NO: 638), hsa-miR-744_st (SEQ ID NO: 619), hsa-miR-758_st (SEQ ID NO: 35), hsa-miR-935_st (SEQ ID NO: 639), hsa-miR-99b-star_st (SEQ ID NO: 569), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to suberoylanilide hydroxamic acid (SAHA, vorinostat); or xxxi) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from HBII-85-11_st (SEQ ID NO: 470), HBII-85-1_x_st (SEQ ID NO: 640), HBII-85-23_x_st (SEQ ID NO: 641), HBII-85-29_st (SEQ ID NO: 642), HBII-85-29_x_st (SEQ ID NO: 642), U28_st (SEQ ID NO: 643), hsa-miR-155_st (SEQ ID NO: 20), hsa-miR-196b_st (SEQ ID NO: 644), hsa-miR-200a-star_st (SEQ ID NO: 553), hsa-miR-200a_st (SEQ ID NO: 554), hsa-miR-200b-star_st (SEQ ID NO: 555), hsa-miR-200b_st (SEQ ID NO: 544), hsa-miR-203_st (SEQ ID NO: 511), hsa-miR-29b_st (SEQ ID NO: 545), hsa-miR-30c_st (SEQ ID NO: 301), hsa-miR-371-3p_st (SEQ ID NO: 645), hsa-miR-371-5p_st (SEQ ID NO: 236), hsa-miR-372_st (SEQ ID NO: 646), hsa-miR-373_st (SEQ ID NO: 408), hsa-miR-516a-5p_st (SEQ ID NO: 558), hsa-miR-518d-5p_st (SEQ ID NO: 572), hsa-miR-518e-star_st (SEQ ID NO: 573), hsa-miR-519a-star_st (SEQ ID NO: 573), hsa-miR-519a_st (SEQ ID NO: 574), hsa-miR-519b-5p_st (SEQ ID NO: 573), hsa-miR-519c-5p_st (SEQ ID NO: 573), hsa-miR-523-star_st (SEQ ID NO: 573), and hsa-miR-886-3p_st (SEQ ID NO: 647), wherein said device allows a determination of the resistance of said patient to depsipeptide (FR901228); or xxxii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from HBII-438A_s_st (SEQ ID NO: 648), HBII-52-32_x_st (SEQ ID NO: 649), HBII-85-1_x_st (SEQ ID NO: 640), HBII-85-23_x_st (SEQ ID NO: 650), hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-125a-3p_st (SEQ ID NO: 601), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-149_st (SEQ ID NO: 500), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-193b_st (SEQ ID NO: 583), hsa-miR-21-star_st (SEQ ID NO: 166), hsa-miR-21_st (SEQ ID NO: 592), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-23a-star_st (SEQ ID NO: 604), hsa-miR-23a_st (SEQ ID NO: 571), hsa-miR-24-2-star_st (SEQ ID NO: 579), hsa-miR-24_st (SEQ ID NO: 580), hsa-miR-27a-star_st (SEQ ID NO: 593), hsa-miR-27a_st (SEQ ID NO: 501), hsa-miR-30a-star_st (SEQ ID NO: 502), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-30c-2-star_st (SEQ ID NO: 504), hsa-miR-30c_st (SEQ ID NO: 301), hsa-miR-31-star_st (SEQ ID NO: 614), hsa-miR-516a-5p_st (SEQ ID NO: 558), hsa-miR-518d-5p_st (SEQ ID NO: 572), hsa-miR-518e-star_st (SEQ ID NO: 573), hsa-miR-519a-star_st (SEQ ID NO: 573), hsa-miR-519c-5p_st (SEQ ID NO: 573), hsa-miR-522-star_st (SEQ ID NO: 573), hsa-miR-9-star_st (SEQ ID NO: 651), hsa-miR-935_st (SEQ ID NO: 639), hsa-miR-98_st (SEQ ID NO: 652), hsa-miR-99b-star_st (SEQ ID NO: 569), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to bortezomib; or xxxiii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-10a_st (SEQ ID NO: 538), hsa-miR-125a-3p_st (SEQ ID NO: 601), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-1287_st (SEQ ID NO: 603), hsa-miR-141_st (SEQ ID NO: 552), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-182_st (SEQ ID NO: 563), hsa-miR-183-star_st (SEQ ID NO: 564), hsa-miR-183_st (SEQ ID NO: 565), hsa-miR-192_st (SEQ ID NO: 542), hsa-miR-193b_st (SEQ ID NO: 583), hsa-miR-194_st (SEQ ID NO: 543), hsa-miR-200b-star_st (SEQ ID NO: 555), hsa-miR-200b_st (SEQ ID NO: 544), hsa-miR-200c_st (SEQ ID NO: 556), hsa-miR-203_st (SEQ ID NO: 511), hsa-miR-21_st (SEQ ID NO: 592), hsa-miR-221-star_st (SEQ ID NO: 613), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-23a_st (SEQ ID NO: 571), hsa-miR-23b-star_st (SEQ ID NO: 591), hsa-miR-23b_st (SEQ ID NO: 590), hsa-miR-24_st (SEQ ID NO: 580), hsa-miR-27b_st (SEQ ID NO: 567), hsa-miR-29b_st (SEQ ID NO: 545), hsa-miR-30b_st (SEQ ID NO: 546), hsa-miR-30d_st (SEQ ID NO: 547), hsa-miR-320d_st (SEQ ID NO: 91), hsa-miR-584_st (SEQ ID NO: 581), hsa-miR-99b-star_st (SEQ ID NO: 569), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to leukeran; or xxxiv) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from U91_s_st (SEQ ID NO: 653), hsa-miR-10a_st (SEQ ID NO: 538), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-134_st (SEQ ID NO: 164), hsa-miR-141-star_st (SEQ ID NO: 562), hsa-miR-141_st (SEQ ID NO: 552), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-192_st (SEQ ID NO: 542), hsa-miR-193b_st (SEQ ID NO: 583), hsa-miR-194_st (SEQ ID NO: 543), hsa-miR-200a-star_st (SEQ ID NO: 553), hsa-miR-200a_st (SEQ ID NO: 554), hsa-miR-200b-star_st (SEQ ID NO: 555), hsa-miR-200b_st (SEQ ID NO: 544), hsa-miR-200c_st (SEQ ID NO: 556), hsa-miR-203_st (SEQ ID NO: 511), hsa-miR-205_st (SEQ ID NO: 295), hsa-miR-210_st (SEQ ID NO: 635), hsa-miR-215_st (SEQ ID NO: 566), hsa-miR-23b-star_st (SEQ ID NO: 591), hsa-miR-23b_st (SEQ ID NO: 590), hsa-miR-24_st (SEQ ID NO: 580), hsa-miR-27b-star_st (SEQ ID NO: 654), hsa-miR-27b_st (SEQ ID NO: 567), hsa-miR-299-5p_st (SEQ ID NO: 606), hsa-miR-320a_st (SEQ ID NO: 655), hsa-miR-320b_st (SEQ ID NO: 656), hsa-miR-320c_st (SEQ ID NO: 90), hsa-miR-320d_st (SEQ ID NO: 91), hsa-miR-337-5p_st (SEQ ID NO: 169), hsa-miR-339-3p_st (SEQ ID NO: 272), hsa-miR-339-5p_st (SEQ ID NO: 273), hsa-miR-370_st (SEQ ID NO: 32), hsa-miR-375_st (SEQ ID NO: 297), hsa-miR-382_st (SEQ ID NO: 174), hsa-miR-429_st (SEQ ID NO: 557), hsa-miR-485-5p_st (SEQ ID NO: 179), hsa-miR-487a_st (SEQ ID NO: 609), hsa-miR-494_st (SEQ ID NO: 181), hsa-miR-99b-star_st (SEQ ID NO: 569), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to fludarabine; or xxxv) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from HBII-85-1_x_st (SEQ ID NO: 657), HBII-85-29_st (SEQ ID NO: 535), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-130a_st (SEQ ID NO: 313), hsa-miR-139-5p_st (SEQ ID NO: 658), hsa-miR-149_st (SEQ ID NO: 500), hsa-miR-16_st (SEQ ID NO: 360), hsa-miR-193b_st (SEQ ID NO: 583), hsa-miR-196b_st (SEQ ID NO: 644), hsa-miR-200a_st (SEQ ID NO: 554), hsa-miR-200b-star_st (SEQ ID NO: 555), hsa-miR-200b_st (SEQ ID NO: 544), hsa-miR-203_st (SEQ ID NO: 511), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-26a_st (SEQ ID NO: 537), hsa-miR-29b_st (SEQ ID NO: 545), hsa-miR-30a-star_st (SEQ ID NO: 502), hsa-miR-30a_st (SEQ ID NO:503), hsa-miR-30c-2-star_st (SEQ ID NO: 504), hsa-miR-30c_st (SEQ ID NO: 301), hsa-miR-331-3p_st (SEQ ID NO: 568), hsa-miR-34a_st (SEQ ID NO: 234), hsa-miR-34b-star_st (SEQ ID NO: 534), hsa-miR-34c-3p_st (SEQ ID NO: 314), hsa-miR-34c-5p_st (SEQ ID NO: 506), hsa-miR-449a_st (SEQ ID NO: 287), hsa-miR-449b_st (SEQ ID NO: 288), hsa-miR-516a-5p_st (SEQ ID NO: 558), and hsa-miR-675_st (SEQ ID NO: 516), wherein said device allows a determination of the resistance of said patient to vinblastine; or xxxvi) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7b_st (SEQ ID NO: 600), hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-10a_st (SEQ ID NO: 538), hsa-miR-125a-3p_st (SEQ ID NO: 601), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-149_st (SEQ ID NO: 500), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-182_st (SEQ ID NO: 563), hsa-miR-183-star_st (SEQ ID NO: 564), hsa-miR-183_st (SEQ ID NO: 565), hsa-miR-193b_st (SEQ ID NO: 583), hsa-miR-203_st (SEQ ID NO: 511), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-23a_st (SEQ ID NO: 571), hsa-miR-23b_st (SEQ ID NO: 590), hsa-miR-24-1-star_st (SEQ ID NO: 659), hsa-miR-24_st (SEQ ID NO: 580), hsa-miR-27b_st (SEQ ID NO: 567), hsa-miR-30b_st (SEQ ID NO: 546), hsa-miR-30d_st (SEQ ID NO: 547), hsa-miR-320d_st (SEQ ID NO: 91), hsa-miR-532-3p_st (SEQ ID NO: 97), hsa-miR-99b-star_st (SEQ ID NO: 569), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to busulfan; or xxxvii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-103_st (SEQ ID NO: 660), hsa-miR-107_st (SEQ ID NO: 661), hsa-miR-1180_st (SEQ ID NO: 662), hsa-miR-1231_st (SEQ ID NO: 663), hsa-miR-125a-3p_st (SEQ ID NO: 601), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-1301_st (SEQ ID NO: 597), hsa-miR-1303_st (SEQ ID NO: 561), hsa-miR-132_st (SEQ ID NO: 664), hsa-miR-141_st (SEQ ID NO: 552), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-182_st (SEQ ID NO: 563), hsa-miR-183_st (SEQ ID NO: 565), hsa-miR-192_st (SEQ ID NO: 542), hsa-miR-194_st (SEQ ID NO: 543), hsa-miR-200b_st (SEQ ID NO: 544), hsa-miR-200c_st (SEQ ID NO: 556), hsa-miR-215_st (SEQ ID NO: 566), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-24_st (SEQ ID NO: 580), hsa-miR-28-3p_st (SEQ ID NO: 605), hsa-miR-28-5p_st (SEQ ID NO: 594), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-30b_st (SEQ ID NO: 546), hsa-miR-30d_st (SEQ ID NO: 547), hsa-miR-324-5p_st (SEQ ID NO: 665), hsa-miR-339-3p_st (SEQ ID NO: 272), hsa-miR-34a-star_st (SEQ ID NO: 277), hsa-miR-34a_st (SEQ ID NO: 234), hsa-miR-429_st (SEQ ID No: 557), hsa-miR-589_st (SEQ ID NO: 666), hsa-miR-934_st (SEQ ID NO: 517), hsa-miR-935_st (SEQ ID NO: 639), hsa-miR-99b-star_st (SEQ ID NO: 569), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to dacarbazine; or xxxviii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-100_st (SEQ ID NO: 17), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-125b-1-star_st (SEQ ID NO: 163), hsa-miR-125b_st (SEQ ID NO: 602), hsa-miR-1269_st (SEQ ID NO: 667), hsa-miR-1270_st (SEQ ID NO: 668), hsa-miR-130a_st (SEQ ID NO: 313), hsa-miR-134_st (SEQ ID NO: 164), hsa-miR-143_st (SEQ ID NO: 31), hsa-miR-145_st (SEQ ID NO: 669), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-181a-2-star_st (SEQ ID NO: 612), hsa-miR-193a-3p_st (SEQ ID NO: 366), hsa-miR-193a-5p_st (SEQ ID NO: 165), hsa-miR-217_st (SEQ ID NO: 670), hsa-miR-21_st (SEQ ID NO: 592), hsa-miR-221-star_st (SEQ ID NO: 613), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-23a-star_st (SEQ ID NO: 604), hsa-miR-23a_st (SEQ ID NO: 571), hsa-miR-23b-star_st (SEQ ID NO: 591), hsa-miR-23b_st (SEQ ID NO: 590), hsa-miR-24-2-star_st (SEQ ID NO: 579), hsa-miR-24_st (SEQ ID NO: 580), hsa-miR-27a-star_st (SEQ ID NO: 593), hsa-miR-27a_st (SEQ ID NO: 501), hsa-miR-27b-star_st (SEQ ID NO: 654), hsa-miR-27b_st (SEQ ID NO: 567), hsa-miR-28-3p_st (SEQ ID NO: 605), hsa-miR-28-5p_st (SEQ ID NO: 594), hsa-miR-30a-star_st (SEQ ID NO: 502), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-30c-2-star_st (SEQ ID NO: 504), hsa-miR-34c-5p_st (SEQ ID NO: 506), hsa-miR-376a_st (SEQ ID NO: 607), hsa-miR-455-3p_st (SEQ ID NO: 178), hsa-miR-543_st (SEQ ID NO: 182), hsa-miR-574-3p_st (SEQ ID NO: 671), hsa-miR-99b-star_st (SEQ ID NO: 569), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to oxaliplatin; or xxxix) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-103_st (SEQ ID NO: 660), hsa-miR-107_st (SEQ ID NO: 661), hsa-miR-10a_st (SEQ ID NO: 538), hsa-miR-1180_st (SEQ ID NO: 662), hsa-miR-125a-3p_st (SEQ ID NO: 601), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-1287_st (SEQ ID NO: 603), hsa-miR-132_st (SEQ ID NO: 664), hsa-miR-149_st (SEQ ID NO: 500), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-182_st (SEQ ID NO: 563), hsa-miR-183_st (SEQ ID NO: 565), hsa-miR-193b_st (SEQ ID NO: 583), hsa-miR-195_st (SEQ ID NO: 672), hsa-miR-21_st (SEQ ID NO: 592), hsa-miR-221-star_st (SEQ ID NO: 613), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-23a_st (SEQ ID NO: 571), hsa-miR-23b_st (SEQ ID NO: 590), hsa-miR-24_st (SEQ ID NO: 580), hsa-miR-26a_st (SEQ ID NO: 537), hsa-miR-27b_st (SEQ ID NO: 567), hsa-miR-28-3p_st (SEQ ID NO: 605), hsa-miR-28-5p_st (SEQ ID NO: 594), hsa-miR-30a-star_st (SEQ ID NO: 502), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-30b-star_st (SEQ ID NO: 673), hsa-miR-30b_st (SEQ ID NO: 546), hsa-miR-30d_st (SEQ ID NO: 547), hsa-miR-320d_st (SEQ ID NO: 91), hsa-miR-34a_st (SEQ ID NO: 234), hsa-miR-501-3p_st (SEQ ID NO: 95), hsa-miR-532-3p_st (SEQ ID NO: 97), hsa-miR-584_st (SEQ ID NO: 581), hsa-miR-99b-star_st (SEQ ID NO: 569), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to hydroxyurea; or xl) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from 14qII-14_st (SEQ ID NO: 674), 14qII-14_x_st (SEQ ID NO: 627), 14qII-1_st (SEQ ID NO: 675), 14qII-1_x_st (SEQ ID NO: 599), 14qII-26_st (SEQ ID NO: 676), hsa-let-7a_st (SEQ ID NO: 575), hsa-let-7e_st (SEQ ID NO: 549), hsa-let-7f_st (SEQ ID NO: 577), hsa-miR-100_st (SEQ ID NO: 17), hsa-miR-10b_st (SEQ ID NO: 550), hsa-miR-125a-3p_st (SEQ ID NO: 601), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-125b-1-star_st (SEQ ID NO: 163), hsa-miR-125b_st (SEQ ID NO: 602), hsa-miR-130a_st (SEQ ID NO: 313), hsa-miR-134_st (SEQ ID NO: 164), hsa-miR-149_st (SEQ ID NO: 500), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-181a-2-star_st (SEQ ID NO: 612), hsa-miR-217_st (SEQ ID NO: 670), hsa-miR-21_st (SEQ ID NO: 592), hsa-miR-22-star_st (SEQ ID NO: 578), hsa-miR-221-star_st (SEQ ID NO: 613), hsa-miR-221_st (SEQ ID NO: 620), hsa-miR-222-star_st (SEQ ID NO: 677), hsa-miR-27b_st (SEQ ID NO: 567), hsa-miR-299-3p_st (SEQ ID NO: 168), hsa-miR-299-5p_st (SEQ ID NO: 606), hsa-miR-30a-star_st (SEQ ID NO: 502), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-30c-2-star_st (SEQ ID NO: 504), hsa-miR-30c_st (SEQ ID NO: 301), hsa-miR-30e-star_st (SEQ ID NO: 505), hsa-miR-337-5p_st (SEQ ID NO: 169), hsa-miR-376a_st (SEQ ID NO: 607), hsa-miR-376c_st (SEQ ID NO: 170), hsa-miR-377-star_st (SEQ ID NO: 171), hsa-miR-379_st (SEQ ID NO: 172), hsa-miR-382_st (SEQ ID NO: 174), hsa-miR-409-3p_st (SEQ ID NO: 81), hsa-miR-409-5p_st (SEQ ID NO: 175), hsa-miR-411_st (SEQ ID NO: 176), hsa-miR-485-5p_st (SEQ ID NO: 179), hsa-miR-487a_st (SEQ ID NO: 609), hsa-miR-487b_st (SEQ ID NO: 82), hsa-miR-495_st (SEQ ID NO: 610), hsa-miR-543_st (SEQ ID NO: 182), hsa-miR-654-5p_st (SEQ ID NO: 611), hsa-miR-758_st (SEQ ID NO: 35), hsa-miR-9-star_st (SEQ ID NO: 651), hsa-miR-98_st (SEQ ID NO: 652), hsa-miR-99b-star_st (SEQ ID NO: 569), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to tegafur; or xli) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-10a_st (SEQ ID NO: 538), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-146a_st (SEQ ID NO: 19), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-193b_st (SEQ ID NO: 583), hsa-miR-200b-star_st (SEQ ID NO: 555), hsa-miR-200b_st (SEQ ID NO: 544), hsa-miR-203_st (SEQ ID NO: 511), hsa-miR-221-star_st (SEQ ID NO: 613), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-23a_st (SEQ ID NO: 571), hsa-miR-24-2-star_st (SEQ ID NO: 579), hsa-miR-24_st (SEQ ID NO: 580), hsa-miR-27a_st (SEQ ID NO: 501), hsa-miR-29a_st (SEQ ID NO: 584), hsa-miR-29b-1-star_st (SEQ ID NO: 622), hsa-miR-29b_st (SEQ ID NO: 545), hsa-miR-30a-star_st (SEQ ID NO: 502), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-30b_st (SEQ ID NO: 546), hsa-miR-30c-2-star_st (SEQ ID NO: 504), hsa-miR-30c_st (SEQ ID NO: 301), hsa-miR-30d_st (SEQ ID NO: 547), hsa-miR-30e-star_st (SEQ ID NO: 505), hsa-miR-372_st (SEQ ID NO: 646), hsa-miR-373_st (SEQ ID NO: 408), hsa-miR-516a-5p_st (SEQ ID NO: 558), hsa-miR-518e-star_st (SEQ ID NO: 573), hsa-miR-519a-star_st (SEQ ID NO: 573), hsa-miR-519a_st (SEQ ID NO: 574), hsa-miR-519b-5p_st (SEQ ID NO: 573), hsa-miR-519c-5p_st (SEQ ID NO: 573), hsa-miR-522-star_st (SEQ ID NO: 573), hsa-miR-523-star_st (SEQ ID NO: 573), hsa-miR-526a_st (SEQ ID NO: 572), hsa-miR-584_st (SEQ ID NO: 581), hsa-miR-675_st (SEQ ID NO: 516), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to daunorubicin; or xlii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from HBII-180C_st (SEQ ID NO: 678), HBII-180C_x_st (SEQ ID NO: 491), hsa-miR-106a_st (SEQ ID NO: 150), hsa-miR-106b-star_st (SEQ ID NO: 2), hsa-miR-106b_st (SEQ ID NO: 37), hsa-miR-107_st (SEQ ID NO: 661), hsa-miR-1207-5p_st (SEQ ID NO: 109), hsa-miR-1244_st (SEQ ID NO: 560), hsa-miR-128_st (SEQ ID NO: 110), hsa-miR-1292_st (SEQ ID NO: 499), hsa-miR-1306_st (SEQ ID NO: 679), hsa-miR-1307_st (SEQ ID NO: 102), hsa-miR-130b_st (SEQ ID NO: 403), hsa-miR-141_st (SEQ ID NO: 552), hsa-miR-15b_st (SEQ ID NO: 510), hsa-miR-17_st (SEQ ID NO: 152), hsa-miR-183_st (SEQ ID NO: 565), hsa-miR-185-star_st (SEQ ID NO: 406), hsa-miR-185_st (SEQ ID NO: 85), hsa-miR-188-5p_st (SEQ ID NO: 86), hsa-miR-18a-star_st (SEQ ID NO: 71), hsa-miR-18a_st (SEQ ID NO: 72), hsa-miR-18b_st (SEQ ID NO: 87), hsa-miR-192_st (SEQ ID NO: 542), hsa-miR-19b_st (SEQ ID NO: 153), hsa-miR-200c-star_st (SEQ ID NO: 231), hsa-miR-200c_st (SEQ ID NO: 556), hsa-miR-203_st (SEQ ID NO: 511), hsa-miR-205_st (SEQ ID NO: 295), hsa-miR-20a_st (SEQ ID NO: 218), hsa-miR-20b_st (SEQ ID NO: 88), hsa-miR-215_st (SEQ ID NO: 566), hsa-miR-25-star_st (SEQ ID NO: 3), hsa-miR-25_st (SEQ ID NO: 89), hsa-miR-30b_st (SEQ ID NO: 546), hsa-miR-30d_st (SEQ ID NO: 547), hsa-miR-320d_st (SEQ ID NO: 91), hsa-miR-324-5p_st (SEQ ID NO: 665), hsa-miR-362-5p_st (SEQ ID NO: 92), hsa-miR-378-star_st (SEQ ID NO: 409), hsa-miR-421_st (SEQ ID NO: 512), hsa-miR-422a_st (SEQ ID NO: 410), hsa-miR-425_st (SEQ ID NO: 286), hsa-miR-500-star_st (SEQ ID NO: 93), hsa-miR-500_st (SEQ ID NO: 94), hsa-miR-501-3p_st (SEQ ID NO: 95), hsa-miR-532-3p_st (SEQ ID NO: 97), hsa-miR-532-5p_st (SEQ ID NO: 98), hsa-miR-584_st (SEQ ID NO: 581), hsa-miR-625_st (SEQ ID NO: 548), hsa-miR-660_st (SEQ ID NO: 305), hsa-miR-720_st (SEQ ID NO: 680), hsa-miR-93-star_st (SEQ ID NO: 45), hsa-miR-934_st (SEQ ID NO: 517), hsa-miR-93_st (SEQ ID NO: 46), and hsa-miR-941_st (SEQ ID NO: 595), wherein said device allows a determination of the resistance of said patient to bleomycin; or xliii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-135b-star_st (SEQ ID NO: 681), hsa-miR-192-star_st (SEQ ID NO: 541), hsa-miR-194-star_st (SEQ ID NO: 230), hsa-miR-21-star_st (SEQ ID NO: 166), hsa-miR-23b_st (SEQ ID NO: 590), hsa-miR-27b-star_st (SEQ ID NO: 654), hsa-miR-552_st (SEQ ID NO: 682), hsa-miR-592_st (SEQ ID NO: 683), hsa-miR-7_st (SEQ ID NO: 570), and hsa-miR-874_st (SEQ ID NO: 310), wherein said device allows a determination of the sensitivity of said patient to estramustine; or xliv) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-100_st (SEQ ID NO: 17), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-217_st (SEQ ID NO: 670), hsa-miR-221-star_st (SEQ ID NO: 613), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-23a_st (SEQ ID NO: 571), hsa-miR-23b_st (SEQ ID NO: 590), hsa-miR-24-2-star_st (SEQ ID NO: 579), hsa-miR-24_st (SEQ ID NO: 580), hsa-miR-30d_st (SEQ ID NO: 547), hsa-miR-320d_st (SEQ ID NO: 91), hsa-miR-512-3p_st (SEQ ID NO: 523), hsa-miR-519b-5p_st (SEQ ID NO: 573), hsa-miR-519c-5p_st (SEQ ID NO: 573), hsa-miR-526a_st (SEQ ID NO: 572), hsa-miR-584_st (SEQ ID NO: 581), hsa-miR-99b-star_st (SEQ ID NO: 569), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to mechlorethamine; or xlv) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-26a_st (SEQ ID NO: 537), hsa-miR-34b-star_st (SEQ ID NO: 534), hsa-miR-34c-5p_st (SEQ ID NO: 506), hsa-miR-516a-5p_st (SEQ ID NO: 558), hsa-miR-518e-star_st (SEQ ID NO: 573), hsa-miR-519a_st (SEQ ID NO: 574), hsa-miR-519c-5p_st (SEQ ID NO: 573), and hsa-miR-526a_st (SEQ ID NO: 572), wherein said device allows a determination of the resistance of said patient to streptozocin; or xlvi) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7b_st (SEQ ID NO: 600), hsa-let-7c_st (SEQ ID NO: 576), hsa-let-7d_st (SEQ ID NO: 623), hsa-let-7f_st (SEQ ID NO: 577), hsa-let-7g_st (SEQ ID NO: 624), hsa-let-7i_st (SEQ ID NO: 596), hsa-miR-130a_st (SEQ ID NO: 313), hsa-miR-181a_st (SEQ ID NO: 78), hsa-miR-193a-3p_st (SEQ ID NO: 366), hsa-miR-24-2-star_st (SEQ ID NO: 579), hsa-miR-24_st (SEQ ID NO: 580), hsa-miR-28-3p_st (SEQ ID NO: 605), hsa-miR-28-5p_st (SEQ ID NO: 594), hsa-miR-29b_st (SEQ ID NO: 545), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-331-3p_st (SEQ ID NO: 568), and hsa-miR-98_st (SEQ ID NO: 652), wherein said device allows a determination of the sensitivity of said patient to carmustine; or xlvii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-125a-3p_st (SEQ ID NO: 601), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-193b_st (SEQ ID NO: 583), hsa-miR-200a_st (SEQ ID NO: 554), hsa-miR-200b-star_st (SEQ ID NO: 555), hsa-miR-200b_st (SEQ ID NO: 544), hsa-miR-200c_st (SEQ ID NO: 556), hsa-miR-21_st (SEQ ID NO: 592), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-31-star_st (SEQ ID NO: 614), hsa-miR-331-3p_st (SEQ ID NO: 568), hsa-miR-34a_st (SEQ ID NO: 234), hsa-miR-34c-5p_st (SEQ ID NO: 506), hsa-miR-935_st (SEQ ID NO: 639), hsa-miR-99b-star_st (SEQ ID NO: 569), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the sensitivity of said patient to lomustine; or xlviii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7e_st (SEQ ID NO: 549), hsa-let-7i_st (SEQ ID NO: 596), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-22-star_st (SEQ ID NO: 578), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-23a_st (SEQ ID NO: 571), hsa-miR-23b_st (SEQ ID NO: 590), hsa-miR-27b_st (SEQ ID NO: 567), hsa-miR-28-3p_st (SEQ ID NO: 605), hsa-miR-28-5p_st (SEQ ID NO: 594), hsa-miR-494_st (SEQ ID NO: 181), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to mercaptopurine; or xlix) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-10a_st (SEQ ID NO: 538), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-193b_st (SEQ ID NO: 583), hsa-miR-221-star_st (SEQ ID NO: 613), hsa-miR-23a_st (SEQ ID NO: 571), hsa-miR-30a-star_st (SEQ ID NO: 502), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-30b_st (SEQ ID NO: 546), hsa-miR-30c-2-star_st (SEQ ID NO: 504), hsa-miR-30c_st (SEQ ID NO: 301), hsa-miR-30d_st (SEQ ID NO: 547), hsa-miR-516a-5p_st (SEQ ID NO: 558), hsa-miR-518e-star_st (SEQ ID NO: 573), hsa-miR-519a_st (SEQ ID NO: 574), hsa-miR-519c-5p_st (SEQ ID NO: 573), hsa-miR-526a_st (SEQ ID NO: 572), hsa-miR-584_st (SEQ ID NO: 581), hsa-miR-99b-star_st (SEQ ID NO: 569), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to teniposide; or l) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-130a_st (SEQ ID NO: 313), hsa-miR-193b_st (SEQ ID NO: 583), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-23a_st (SEQ ID NO: 571), hsa-miR-24-2-star_st (SEQ ID NO: 579), hsa-miR-27a-star_st (SEQ ID NO: 593), hsa-miR-27a_st (SEQ ID NO: 501), hsa-miR-29b_st (SEQ ID NO: 545), hsa-miR-30a-star_st (SEQ ID NO: 502), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-30c-2-star_st (SEQ ID NO: 504), hsa-miR-30c_st (SEQ ID NO: 301), hsa-miR-34c-5p_st (SEQ ID NO: 506), hsa-miR-372_st (SEQ ID NO: 646), hsa-miR-516a-5p_st (SEQ ID NO: 558), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to dactinomycin; or li) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7e_st (SEQ ID NO: 549), hsa-let-7i_st (SEQ ID NO: 596), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-181a-2-star_st (SEQ ID NO: 612), hsa-miR-21-star_st (SEQ ID NO: 166), hsa-miR-21_st (SEQ ID NO: 592), hsa-miR-221_st (SEQ ID NO: 620), hsa-miR-222_st (SEQ ID NO: 621), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-28-3p_st (SEQ ID NO: 605), hsa-miR-28-5p_st (SEQ ID NO: 594), hsa-miR-30a-star_st (SEQ ID NO: 502), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-30c-2-star_st (SEQ ID NO: 504), hsa-miR-455-3p_st (SEQ ID NO: 178), and hsa-miR-99b-star_st (SEQ ID NO: 569), wherein said device allows a determination of the resistance of said patient to tretinoin; or lii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-182_st (SEQ ID NO: 563), hsa-miR-183_st (SEQ ID NO: 565), hsa-miR-193b_st (SEQ ID NO: 583), hsa-miR-195_st (SEQ ID NO: 672), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-23a_st (SEQ ID NO: 571), hsa-miR-23b_st (SEQ ID NO: 590), hsa-miR-24_st (SEQ ID NO: 580), hsa-miR-27a-star_st (SEQ ID NO: 593), hsa-miR-27a_st (SEQ ID NO: 501), hsa-miR-27b_st (SEQ ID NO: 567), hsa-miR-34b-star_st (SEQ ID NO: 534), hsa-miR-497_st (SEQ ID NO: 684), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to ifosfamide; or liii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7a_st (SEQ ID NO: 575), hsa-let-7b_st (SEQ ID NO: 600), hsa-let-7c_st (SEQ ID NO: 576), hsa-let-7e_st (SEQ ID NO: 549), hsa-let-7g_st (SEQ ID NO: 624), hsa-let-7i_st (SEQ ID NO: 596), hsa-miR-100_st (SEQ ID NO: 17), hsa-miR-10a_st (SEQ ID NO: 538), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-125b_st (SEQ ID NO: 602), hsa-miR-130a_st (SEQ ID NO: 313), hsa-miR-138_st (SEQ ID NO: 625), hsa-miR-149_st (SEQ ID NO: 500), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-181a-2-star_st (SEQ ID NO: 612), hsa-miR-193b-star st (SEQ ID NO: 633), hsa-miR-193b_st (SEQ ID NO: 583), hsa-miR-21_st (SEQ ID NO: 592), hsa-miR-22-star_st (SEQ ID NO: 578), hsa-miR-221_st (SEQ ID NO: 620), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-23a_st (SEQ ID NO: 571), hsa-miR-23b_st (SEQ ID NO: 590), hsa-miR-24-2-star_st (SEQ ID NO: 579), hsa-miR-24_st (SEQ ID NO: 580), hsa-miR-28-3p_st (SEQ ID NO: 605), hsa-miR-28-5p_st (SEQ ID NO: 594), hsa-miR-30a-star_st (SEQ ID NO: 502), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-30c-2-star_st (SEQ ID NO: 504), hsa-miR-30c_st (SEQ ID NO: 301), hsa-miR-30e-star_st (SEQ ID NO: 505), hsa-miR-34c-5p_st (SEQ ID NO: 506), hsa-miR-424-star_st (SEQ ID NO: 100), hsa-miR-455-3p_st (SEQ ID NO: 178), hsa-miR-503_st (SEQ ID NO: 101), hsa-miR-935_st (SEQ ID NO: 639), hsa-miR-99b-star_st (SEQ ID NO: 569), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to tamoxifen; or liv) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-193b_st (SEQ ID NO: 583), hsa-miR-30b_st (SEQ ID NO: 546), hsa-miR-30d_st (SEQ ID NO: 547), hsa-miR-320d_st (SEQ ID NO: 91), hsa-miR-584_st (SEQ ID NO: 581), and hsa-miR-99b_st (SEQ ID NO: 559), wherein said device allows a determination of the resistance of said patient to irinotecan; or lv) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-30b_st (SEQ ID NO: 546), hsa-miR-30d_st (SEQ ID NO: 547), and hsa-miR-584_st (SEQ ID NO: 581), wherein said device allows a determination of the resistance of said patient to floxuridine; and/or lvi) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7b_st (SEQ ID NO: 600), hsa-let-7c_st (SEQ ID No: 576), hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-151-5p_st (SEQ ID NO: 540), hsa-miR-217_st (SEQ ID NO: 670), hsa-miR-21_st (SEQ ID NO: 592), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-23a_st (SEQ ID NO: 571), hsa-miR-23b-star_st (SEQ ID NO: 591), hsa-miR-23b_st (SEQ ID NO: 590), hsa-miR-24_st (SEQ ID NO: 580), hsa-miR-27b-star_st (SEQ ID NO: 654), hsa-miR-27b_st (SEQ ID NO: 567), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-494_st (SEQ ID NO: 181), hsa-miR-9-star_st (SEQ ID NO: 651), hsa-miR-99b-star_st (SEQ ID NO: 569), hsa-miR-99b_st (SEQ ID NO: 559), and hsa-miR-9_st (SEQ ID NO: 685), wherein said device allows a determination of the resistance of said patient to thioguanine; or lvii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7e_st (SEQ ID NO: 549), hsa-miR-125a-5p_st (SEQ ID NO: 551), hsa-miR-138_st (SEQ ID NO: 625), hsa-miR-149_st (SEQ ID NO: 500), hsa-miR-193b-star_st (SEQ ID NO: 633), hsa-miR-193b_st (SEQ ID NO: 583), hsa-miR-21_st (SEQ ID NO: 592), hsa-miR-22-star_st (SEQ ID NO: 578), hsa-miR-22_st (SEQ ID NO: 167), hsa-miR-23a_st (SEQ ID NO: 571), hsa-miR-23b_st (SEQ ID NO: 590), hsa-miR-24-2-star_st (SEQ ID NO: 579), hsa-miR-24_st (SEQ ID NO: 580), hsa-miR-27a_st (SEQ ID NO: 501), hsa-miR-27b_st (SEQ ID NO: 567), hsa-miR-30a-star_st (SEQ ID NO: 502), hsa-miR-30a_st (SEQ ID NO: 503), hsa-miR-30c-2-star_st (SEQ ID NO: 504), hsa-miR-30c_st (SEQ ID NO: 301), hsa-miR-543_st (SEQ ID NO: 182), and hsa-miR-9_st (SEQ ID NO: 685), wherein said device allows a determination of the resistance of said patient to PSC 833; or lviii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-320a_st (SEQ ID NO: 655), hsa-miR-320b_st (SEQ ID NO: 656), hsa-miR-320c_st (SEQ ID NO: 90), hsa-miR-362-5p_st (SEQ ID NO: 92), hsa-miR-500-star_st (SEQ ID NO: 93), hsa-miR-500_st (SEQ ID NO: 94), hsa-miR-502-3p_st (SEQ ID NO: 96), hsa-miR-532-3p_st (SEQ ID NO: 97), hsa-miR-532-5p_st (SEQ ID NO: 98), hsa-miR-652_st (SEQ ID NO: 42), and hsa-miR-671-5p_st (SEQ ID NO: 43), wherein said device allows a determination of the resistance of said patient to erlotinib; or lix) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7d_st (SEQ ID NO: 623), hsa-miR-103_st (SEQ ID NO: 660), and hsa-miR-107_st (SEQ ID NO: 661), wherein said device allows a determination of the sensitivity of said patient to herceptin; or lx) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-1287_st (SEQ ID NO: 603), hsa-miR-130a_st (SEQ ID NO: 313), hsa-miR-151-3p_st (SEQ ID NO: 539), hsa-miR-28-3p_st (SEQ ID NO: 605), hsa-miR-28-5p_st (SEQ ID NO: 594), hsa-miR-31-star_st (SEQ ID NO: 614), and hsa-miR-455-3p_st (SEQ ID NO: 178), wherein said device allows a determination of the resistance of said patient to celecoxib; or lxi) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-let-7b_st (SEQ ID NO: 600), hsa-miR-181a-2-star_st (SEQ ID NO: 612), hsa-miR-221_st (SEQ ID NO: 620), hsa-miR-222_st (SEQ ID NO: 621), hsa-miR-28-5p_st (SEQ ID NO: 594), hsa-miR-29a_st (SEQ ID NO: 584), and hsa-miR-31_st (SEQ ID NO: 615), wherein said device allows a determination of the resistance of said patient to fulvestrant; or lxii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-505-star_st (SEQ ID NO: 686), and hsa-miR-671-5p_st (SEQ ID NO: 43), wherein said device allows a determination of the resistance of said patient to iressa; or lxiii) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from U27_st (SEQ ID NO: 687) and U29_st (SEQ ID NO: 203), wherein said device allows a determination of the resistance of said patient to letrozole; or lxiv) one or more single-stranded nucleic acid molecules having at least 85% identity to a target nucleic acid molecule having a sequence that is complementary to or identical to at least 15 consecutive nucleotides of one or more biomarkers selected from hsa-miR-191_st (SEQ ID NO: 284) and hsa-miR-491-5p_st (SEQ ID NO: 617), wherein said device allows a determination of the resistance of said patient to cetuximab. 10. The method of claim 9, wherein said device comprises two or more of said single-stranded nucleic acid molecules of i) to lxiv). 11. The method of claim 1, wherein said treatment is selected from vincristine, cisplatin, etoposide, azaguanine, carboplatin, adriamycin, aclarubicin, mitoxantrone, mitoxantrone, mitomycin, paclitaxel, gemcitabine, docetaxel, dexamethasone, ara-c, methylprednisolone, methotrexate, bleomycin, methyl-gag, belinostat, carboplatin, 5-fu (5-fluorouracil), idarubicin, melphalan, IL4-PR38, valproic acid, all-trans retinoic acid (ATRA), cytoxan, topotecan, suberoylanilide hydroxamic acid (SAHA, vorinostat), depsipeptide (FR901228), bortezomib, leukeran, fludarabine, vinblastine, busulfan, dacarbazine, oxaliplatin, hydroxyurea, tegafur, daunorubicin, estramustine, mechlorethamine, streptozocin, carmustine, lomustine, mercaptopurine, teniposide, dactinomycin, tretinoin, ifosfamide, tamoxifen, irinotecan, floxuridine, thioguanine, PSC 833, erlotinib, herceptin, celecoxib, fulvestrant, iressa, anastrozole, letrozole, cetuximab, rituximab, radiation, histone deacetylase (HDAC) inhibitors, and 5-Aza-2'-deoxycytidine (decitabine). 12. The method of claim 2, wherein said at least one first single-stranded nucleic acid molecule or said at least one second single-stranded nucleic acid molecule of said device has a length in the range of 15 to 100 nucleotides. 13. The method of claim 12, wherein said at least one first single-stranded nucleic acid molecule or said at least one second single-stranded nucleic acid molecule of said device has a length in the range of 20 to 60 nucleotides. 14. The method of claim 2, wherein said method comprises converting the level of expression of said at least one biomarker of sensitivity and/or said at least one biomarker of resistance into a mean score correlation coefficient for said treatment for cancer, wherein said mean score correlation coefficient identifies the sensitivity of said patient to said treatments for cancer. 15. The method of claim 14, wherein said method further comprises subtracting the mean correlation coefficient for said at least one biomarker of resistance from the mean correlation coefficient for said at least one biomarker of sensitivity to obtain a difference score correlation coefficient for said treatment, wherein the difference score correlation coefficient identifies the sensitivity of said patient to said treatment for cancer. 16. The method of claim 15, wherein said mean score correlation coefficient and/or said difference score correlation coefficient above 0.3 indicates said patient is sensitive to said treatment for cancer. 17. The method of claim 2, wherein the level of expression of said at least one biomarker of sensitivity or said at least one biomarker of resistance is determined using a quantitative reverse transcription-polymerase chain reaction (qRT-PCR), by detecting the level of mRNA transcribed from one or more genes, by detecting the level of a protein product of one or more genes, or by detecting the level of the biological activity of a protein product of one or more genes. 18. The method of claim 2, wherein the level of expression of said at least one biomarker of sensitivity or said at least one biomarker of resistance is determined in a cancer cell of said patient. 19. A method of treating a patient having cancer, said method comprising: (a) administering a first cancer treatment to the patient, wherein the patient was previously determined to be responsive to the first cancer treatment according to the method of claim 1; or (b) administering a second cancer treatment that is different from the first cancer treatment to the patient, wherein the patient was previously determined to be non-responsive to the first cancer treatment as a monotherapy according to the method of claim 1. 20. The method of claim 19, wherein the patient in (b) is administered both the first cancer treatment and the second cancer treatment. 21. The method of claim 2, wherein: (a) if the level of expression of the at least one biomarker of sensitivity indicates that the cancer patient is sensitive to the at least one treatment for cancer, said method further comprises administering the at least one treatment for cancer to the cancer patient as a first cancer treatment; or (b) if the level of expression of the at least one biomarker of sensitivity indicates that the cancer patient is not sensitive to the at least one treatment for cancer, said method further comprises administering a second cancer treatment that is different from the first cancer treatment. 22. The method of claim 21, wherein the patient in (b) is administered both the first cancer treatment and the second cancer treatment. 23. The method of claim 2, wherein said device comprises i) and ii), and wherein said device is sufficient for detecting the level of expression of a least one said biomarker of sensitivity and at least one said biomarker of resistance. 24. The method of claim 23, wherein said method comprises detecting the level of expression of said at least one biomarker of sensitivity and said at least one biomarker of resistance in a biological sample from said patient. 25. The method of claim 23, wherein said device allows the determination of the level of expression of said at least one biomarker of sensitivity having a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 4-12, 36, 118, 146, 209, 241, 252, 260, 280, 308, 395, and 441 and a level of expression of said at least one biomarker of resistance having a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 511 and 538-548. 26. The method of claim 1, wherein: (a) if the level of expression of hsa-miR-766_st (SEQ ID NO: 1) indicates that the patient is responsive to the at least one treatment for cancer, said method further comprises administering the at least one treatment for cancer to the patient as a first cancer treatment; or (b) if the level of expression of hsa-miR-766_st (SEQ ID NO: 1) indicates that the patient is non-responsive to the at least one treatment for cancer, said method further comprises administering a second cancer treatment that is different from the first cancer treatment. 27. The method of claim 2, wherein: (a) if the level of expression of the at least one biomarker of resistance indicates that the patient is not resistant to the at least one treatment for cancer, said method further comprises administering the at least one treatment for cancer to the patient as a first cancer treatment; or (b) if the level of expression of the at least one biomarker of resistance indicates that the patient is resistant to the at least one treatment for cancer, said method further comprises administering a second cancer treatment that is different from the first cancer treatment. 28. A method of detecting a level of expression of hsa-miR-766 in a tumor sample from a patient diagnosed with brain cancer, lung cancer, or lymphoma comprising: i) contacting the tumor sample comprising one or more nucleic acid molecules from said patient to one or more probes comprising at least one first single-stranded nucleic acid molecule having at least 85% sequence identity to a nucleic acid sequence that is complementary or identical to at least 15 consecutive nucleotides of hsa-miR-766_st (SEQ ID NO: 1); and ii) detecting the level of expression of hsa-miR-766_st by performing microarray analysis or quantitative reverse transcriptase polymerase chain reaction (qRT-PCR).

Details for Patent 9,598,734

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
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