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Last Updated: April 18, 2024

Claims for Patent: 9,581,598

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Summary for Patent: 9,581,598

Title:	Diagnosis and treatment of brain tumor
Abstract:	Cellular targets on cancer cells have been identified that can be used with targeted molecular imaging to detect the cancer cells in vivo. Non-invasive methods for detecting cancer cells, such as metastasized cancer cells, are therefore provided. Also provided are compositions and kits for use in the disclosed methods.
Inventor(s):	Ruoslahti; Erkki (Buellton, CA), Laakkonen; Pirjo (Helsinki, FI)
Assignee:	Sanford-Burnham Medical Research Institute (La Jolla, CA)
Application Number:	14/396,414
Patent Claims:	1. A method for targeted therapy in a patient with brain cancer comprising administering to a patient in need of such therapy an effective amount of a pharmaceutical composition comprising anti-mammary-derived growth inhibitor (MDGI) antibody and a cancer chemotherapeutic agent. 2. The method according to claim 1 further comprising combining the targeted therapy with a cancer therapy, wherein the cancer therapy cancer is radiation therapy, surgery, siRNA or shRNA for MDGI to inhibit MDGI expression or function in the brain of the patient, or combinations thereof. 3. The method of claim 1, wherein the chemotherapeutic agent is selected from the group consisting of a taxane, an antracyclin, an alkylating agent, a vinca alkaloid, an anti-metabolite, a platinum agent, a steroid, an antibiotic, a selective estrogen receptor modulator and an antibody cancer therapeutic agent. 4. The method of claim 3, wherein the cancer therapeutic agent is selected from the group consisting of docetaxel, doxorubicin, cisplatin, carboplatin, methotrexate, adriamycin, and trastuzumab. 5. The method of claim 2, wherein the composition further comprises a peptide comprising SEQ ID NO:5 or a variant thereof. 6. The method of claim 5, wherein the anti-MDGI antibody is conjugated to SEQ ID NO:5 or a variant thereof. 7. The method of claim 2, wherein the composition is administered after surgical removal of the brain tumor.

Details for Patent 9,581,598

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	09/25/1998	⤷ Try a Trial	2032-04-25
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	02/10/2017	⤷ Try a Trial	2032-04-25
Genentech, Inc.	HERCEPTIN HYLECTA	trastuzumab and hyaluronidase-oysk	Injection	761106	02/28/2019	⤷ Try a Trial	2032-04-25
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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