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Summary for Patent: 9,561,244
|Title:||Anti-neoplastic compositions comprising extracts of black cohosh|
|Abstract:||A method for treating, preventing or ameliorating breast cancer is provided by administering a synergistic amount of digitoxin and either actein or an extract of black cohosh comprising triterpene glycosides, and optionally another chemopreventive agent which may be paclitaxel. Methods for treating or preventing a neoplasia using a synergistic combination, and compositions of a synergistic combination of a cardiac glycoside and either actein or an extract of black cohosh comprising triterpene glycosides, and optionally another chemopreventive agent which may be a taxane are also provided. The compositions may also be used in a method for modulating Na.sup.+K.sup.+ATPase activity. In addition, a method for inhibiting the progression or development of breast cancer in vivo by administering either actein or an extract of black cohosh comprising triterpene glycosides and optionally at least one other chemoprotective agent is provided.|
|Inventor(s):||Einbond; Linda Saxe (Crestwood, NY)|
|Assignee:||RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (New York, NY)|
|Patent Claims:||1. A method for treating a neoplasia in a human, comprising administering to the human an amount of actein effective to treat the neoplasia and an effective anti-neoplastic
amount of at least one additional chemotherapeutic agent, wherein the at least one additional chemotherapeutic agent is selected from the group consisting of cisplatin, doxorubicin, 5-fluorouracil, herceptin, paclitaxel, and tamoxifen, wherein the amount
of actein is about 0.2 .mu.g/ml to 20.0 .mu.g/ml; and wherein the amount of cisplatin is about 2 .mu.g/ml to 20 .mu.g/ml, the amount of doxorubicin is about 0.02 .mu.g/ml to 0.2 .mu.g/ml, the amount of 5-fluorouracil is about 0.002 .mu.g/ml to 0.2
.mu.g/ml, the amount of herceptin is about 0.8 .mu.g/ml to 32 .mu.g/ml, the amount of tamoxifen is about 2 .mu.g/ml to 50 .mu.g/ml, and the amount of paclitaxel is about 0.5 nM to 5 nM.
2. The method of claim 1, wherein the neoplasia is a carcinoma, a lymphocytic leukemia, a myeloid leukemia, a malignant lymphoma, a malignant melanoma, a myeloproliferative disease, a sarcoma, a brain tumor, a childhood tumor, or a mixed type of neoplasia.
3. The method of claim 2, wherein the carcinoma is a breast carcinoma or a colon carcinoma.
4. The method of claim 1, wherein the chemotherapeutic agent is paclitaxel, wherein the amount of actein is between about 0.5 .mu.g/ml to about 5 .mu.g/ml, and the amount of paclitaxel is between about 0.5 nM to about 5 nM.
5. The method of claim 1, wherein the chemotherapeutic agent is herceptin, wherein the amount of actein is between about 0.2 .mu.g/ml to about 2 .mu.g/ml, and the amount of herceptin is about 8 .mu.g/ml to 32 .mu.g/ml.
|Applicant||Tradename||Biologic Ingredient||Dosage Form||BLA||Number||Approval Date||Patent No.||Assignee||Estimated Patent Expiration||Status||Orphan||Source|
|Genentech||HERCEPTIN||trastuzumab||VIAL; INTRAVENOUS||103792||001||1998-09-25||Start Trial||RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (New York, NY)||2022-12-27||RX||Orphan||search|
|>Applicant||>Tradename||>Biologic Ingredient||>Dosage Form||>BLA||>Number||>Approval Date||>Patent No.||>Assignee||>Estimated Patent Expiration||>Status||>Orphan||>Source|
|Country||Patent Number||Publication Date|
|United States of America||2005008717||Jan 13, 2005|
|United States of America||2009075919||Mar 19, 2009|
|United States of America||2009186837||Jul 23, 2009|
|United States of America||2009264377||Oct 22, 2009|
|>Country||>Patent Number||>Publication Date|
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