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Last Updated: March 28, 2024

Claims for Patent: 9,540,425


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Summary for Patent: 9,540,425
Title:Vaccines against pregnancy-associated malaria
Abstract: The present invention relates to specific regions of the N-terminal portion of the VAR2CSA protein and to the use of such specific regions in the prevention of pregnancy-associated malaria. The invention also provides immunogenic compositions and vaccines that are useful for preventing malaria in pregnant women.
Inventor(s): Ndam; Nicaise Tuikue (Paris, FR), Deloron; Philippe (Paris, FR), Gnidehou; Sedami Ursula Alix Carine (Tavemy, FR), Quiviger; Mickael (Le Grand Quevilly, FR), Bigey; Pascal (Paris, FR), Scherman; Daniel (Paris, FR)
Assignee: INSTITUT DE RECHERCHE POUR LE DeVELOPPEMENT (IRD) (Marseilles, FR)
Application Number:13/812,197
Patent Claims:1. A fusion protein consisting of an isolated polypeptide fused to a fusion partner, wherein the polypeptide consists of the amino acid sequent set forth in SEQ ID NO: 1 or the amino acid sequence set forth in SEQ ID NO: 2.

2. The fusion protein according to claim 1, wherein the fusion partner is selected from the group consisting of maltose binding protein, signal sequence of the maltose binding protein, poly-histidine tag, S-Tag, glutathione-S-transferase, thioredoxin, .beta.-galactosidase, streptavidin, dihydrofolate reductase, pelB signal sequence, ompA signal sequence, signal sequence of alkaline phosphatase, green fluorescent protein (GFP), human growth hormone, interleukin-2 (IL-2), granulocyte macrophage colony stimulating factor (GM-CSF), granulocyte colony stimulating factor (G-CSF), calcitonin, interferon-beta, interferon-alpha, glucagon like peptide 1 (GLP-1), glucagon like peptide 2 (GLP-2), parathyroid hormone PTH(1-34), parathyroid hormone PTH(1-84), butyrylcholinesterase, glucocerebrosidase (GBA), and exendin-4.

3. An immunogenic composition comprising the fusion protein according to claim 1 and at least one pharmaceutically acceptable carrier or excipient.

4. The immunogenic composition according to claim 3, further comprising an adjuvant.

5. An immunogenic composition comprising the fusion protein according to claim 2 and at least one pharmaceutically acceptable carrier or excipient.

6. The immunogenic composition according to claim 5, further comprising an adjuvant.

7. A method of inducing an immune response against Plasmodium falciparum in a female human being, comprising administering to said female human being an effective amount of the immunogenic composition of claim 4.

8. The method according to claim 7, wherein the female human being is a prepubertal girl, a postpupertal girl, or a primigravidae woman.

9. A method of inducing an immune response against Plasmodium falciparum in a female human being, comprising administering to said female human being an effective amount of the immunogenic composition of claim 6.

10. The method according to claim 9, wherein the female human being is a prepubertal girl, a postpupertal girl, or a primigravidae woman.

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