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Generated: September 22, 2017

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Title:Degradable material for use in three dimensional printing and method for preparing the same
Abstract: A liquid composition for producing a self-destructible temporary structure by additive manufacturing is provided. The liquid composition includes a biosynthetic copolymer as a degradable component and an enzyme as a disintegrating agent, the disintegrating agent is capable of disintegrating the degradable component, wherein after exposure to an external trigger, the disintegrating agent gradually degrades the degradable component.
Inventor(s): Dikovsky; Daniel (Rehovot, IL), Napadensky; Eduardo (Netanya, IL)
Assignee: STRATASYS LTD. (Rehovot, IL)
Application Number:13/926,489
Patent Claims:1. A 3-dimensional self-destructible temporary structure for supporting an object during a layer-by layer printing process, the structure comprising: hydrogel layers, wherein each hydrogel layer comprises a polymerized copolymer, and enzyme which is capable of disintegrating the polymerized copolymer, wherein the hydrogel layers form a 3-dimensional self-destructible temporary structure.

2. The 3-dimensional self-destructible temporary structure of claim 1, wherein the copolymer comprises a protein or a peptide.

3. The 3-dimensional self-destructible temporary structure of claim 1, wherein the copolymer comprises any one or more of poly(ethyleneglycol) (PEG), poly(acrylic acid), poly(hyaluronic acid), poly(caprolactone) or poly(vinyl alcohol).

4. The 3-dimensional self-destructible temporary structure of claim 1, wherein the enzyme is an esterase, a trypsin, a collagenase, a cellulase or a dextranase.

5. The 3-dimensional self-destructible temporary structure of claim 4, wherein the esterase is lipase.

6. The 3-dimensional self-destructible temporary structure of claim 1 wherein the enzyme is encapsulated by nanoparticles.

7. The 3-dimensional self-destructible temporary structure of claim 1, wherein the layers of self-destructible temporary structure are formed by inkjet printing.

8. The 3-dimensional self-destructible temporary structure of claim 1, wherein the enzyme comprises hydrogel particles that gradually release enzyme by diffusion.

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Inventors Patent Expiration Status Orphan Source
Advance Biofactures
SANTYL
collagenase
VIAL1019950011965-06-04► Subscribe STRATASYS LTD. (Rehovot, IL) Dikovsky; Daniel (Rehovot, IL), Napadensky; Eduardo (Netanya, IL) ► SubscribeRXsearch
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International Patent Family for Patent: ► Subscribe

Country Document Number Publication Date
United States of America2013337277Dec 19, 2013
United States of America2017106604Apr 20, 2017
United States of America8470231Jun 25, 2013
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Serving 500+ biopharmaceutical companies globally:

Fuji
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Deloitte
Daiichi Sankyo
Chinese Patent Office
Julphar
Boehringer Ingelheim
Farmers Insurance
US Department of Justice
Healthtrust

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