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Serving 500+ biopharmaceutical companies globally:

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Generated: September 19, 2017

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Title:Cancer therapy using beta glucan and antibodies
Abstract: The present invention relates to methods of using neutral soluble glucan and monoclonal antibodies for antitumor therapy. Neutral soluble Beta (1,3; 1,6) glucan (NSG) enhances the tumoricidal activity of the innate immune system by binding to the C3 complement protein receptor CR3. The glucan does not stimulate the induction of inflammatory cytokines. Also described are methods of using whole glucan particles (WGP) as an immunomodulator by inducing a shift from a Th2 response to the Th1 response, leading to an enhanced antitumor cytotoxic T-cell response.
Inventor(s): Ross; Gordon D. (Prospect, KY)
Assignee: University of Louisville Research Foundation, Inc. (Louisville, KY)
Application Number:14/528,900
Patent Claims:1. A method of suppressing or eliminating non-Hodgkin's lymphoma, comprising administering a yeast neutral soluble glucan and rituximab to a subject having non-Hodgkin's lymphoma, wherein the glucan does not induce systemic release of inflammatory cytokines, and the glucan and rituximab together synergistically suppress or eliminate non-Hodgkin's lymphoma.

2. The method of claim 1, wherein the yeast neutral soluble beta glucan is administered parenterally.

3. The method of claim 1, wherein the yeast neutral soluble glucan is in a single helix conformation, a triple helix conformation, or a combination thereof.

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Inventors Patent Expiration Status Orphan Source
VIAL1037050011997-11-26► Subscribe University of Louisville Research Foundation, Inc. (Louisville, KY) Ross; Gordon D. (Prospect, KY) ► SubscribeRXsearch
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International Patent Family for Patent: ► Subscribe

Country Document Number Publication Date
Austria462437Apr 15, 2010
Australia2003268486Mar 29, 2004
Australia2003295326Apr 23, 2004
Canada2496508Apr 15, 2004
Canada2496508Apr 22, 2014
Canada2496596Jun 28, 2016
Canada2496596Mar 18, 2004
China100363054Jan 23, 2008
China1694715Dec 01, 2010
China1694715Nov 09, 2005
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Serving 500+ biopharmaceutical companies globally:

Daiichi Sankyo
US Army
Express Scripts
Queensland Health

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