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Last Updated: March 28, 2024

Claims for Patent: 9,522,187


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Summary for Patent: 9,522,187
Title:Cancer therapy using beta glucan and antibodies
Abstract: The present invention relates to methods of using neutral soluble glucan and monoclonal antibodies for antitumor therapy. Neutral soluble Beta (1,3; 1,6) glucan (NSG) enhances the tumoricidal activity of the innate immune system by binding to the C3 complement protein receptor CR3. The glucan does not stimulate the induction of inflammatory cytokines. Also described are methods of using whole glucan particles (WGP) as an immunomodulator by inducing a shift from a Th2 response to the Th1 response, leading to an enhanced antitumor cytotoxic T-cell response.
Inventor(s): Ross; Gordon D. (Prospect, KY)
Assignee: University of Louisville Research Foundation, Inc. (Louisville, KY)
Application Number:14/528,900
Patent Claims:1. A method of suppressing or eliminating non-Hodgkin's lymphoma, comprising administering a yeast neutral soluble glucan and rituximab to a subject having non-Hodgkin's lymphoma, wherein the glucan does not induce systemic release of inflammatory cytokines, and the glucan and rituximab together synergistically suppress or eliminate non-Hodgkin's lymphoma.

2. The method of claim 1, wherein the yeast neutral soluble beta glucan is administered parenterally.

3. The method of claim 1, wherein the yeast neutral soluble glucan is in a single helix conformation, a triple helix conformation, or a combination thereof.

Details for Patent 9,522,187

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. RITUXAN rituximab Injection 103705 11/26/1997 ⤷  Try a Trial 2022-09-04
Idec Pharmaceuticals Corp. RITUXAN rituximab Injection 103737 02/19/2002 ⤷  Try a Trial 2022-09-04
Genentech, Inc. RITUXAN HYCELA rituximab and hyaluronidase human Injection 761064 06/22/2017 ⤷  Try a Trial 2022-09-04
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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