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Last Updated: March 28, 2024

Claims for Patent: 9,506,924


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Summary for Patent: 9,506,924
Title:Compositions and methods for characterizing a myopathy
Abstract: The invention provides compositions, methods, and kits for diagnosing, monitoring, and otherwise characterizing a myopathy and for detecting the presence of autoantibodies in a biological sample.
Inventor(s): Casciola-Rosen; Livia A. (Pikesville, MD), Christopher-Stine; Lisa (Baltimore, MD), Mammen; Andrew (Baltimore, MD), Rosen; Antony (Pikesville, MD)
Assignee: The Johns Hopkins University (Baltimore, MD)
Application Number:15/143,728
Patent Claims:1. A method for treating an autoimmune-mediated myopathy in a subject, the method comprising: detecting an autoimmune response in the subject by detecting an autoantibody that recognizes a 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) protein; and administering to the subject an immunosuppressive agent to thereby treat the autoimmune-mediated myopathy.

2. The method of claim 1, wherein the immunosuppressant agent is a member selected from the group consisting of a glucocorticoid, a cytostatic agent, and a drug acting on immunophilins.

3. The method of claim 2, wherein the glucocorticoid is prednisone.

4. The method of claim 2, wherein the cytostatic agent is a member selected from the group consisting of azathioprine and methotrexate.

5. The method of claim 2, wherein the drug acting on immunophilins is a member selected from the group consisting of cyclosporine and tacrolimus.

6. The method of claim 2, wherein the immunosuppressant is a member selected from the group consisting of hydroxychloroquine, intravenous immunoglobulin, mycophenylate mofetil, and rituximab.

7. The method of claim 1, wherein the myopathy is an autoimmune-mediated myopathy is associated with statin therapy.

8. The method of claim 1, wherein the HMGCR protein is the full length protein or a fragment thereof having HMGCR antibody binding activity.

9. The method of claim 8, wherein the HMGCR protein fragment comprises amino acids 340-888 of the HMGCR protein.

10. A method for treating an autoimmune-mediated myopathy in a subject, the method comprising: administering to the subject an immunosuppressive agent to treat the autoimmune-mediated myopathy, wherein an autoantibody that recognizes a 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) protein has been detected from said subject.

11. The method of claim 10, wherein the immunosuppressant agent is a member selected from the group consisting of a glucocorticoid, a cytostatic agent, and a drug acting on immunophilins.

12. The method of claim 11, wherein the glucocorticoid is prednisone.

13. The method of claim 11, wherein the cytostatic agent is a member selected from the group consisting of azathioprine and methotrexate.

14. The method of claim 11, wherein the drug acting on immunophilins is a member selected from the group consisting of cyclosporine and tacrolimus.

15. The method of claim 11, wherein the immunosuppressant is a member selected from the group consisting of hydroxychloroquine, intravenous immunoglobulin, mycophenylate mofetil, and rituximab.

16. The method of claim 10, wherein the myopathy is an autoimmune-mediated myopathy is associated with statin therapy.

17. The method of claim 10, wherein the HMGCR protein is the full length protein or a fragment thereof having HMGCR antibody binding activity.

18. The method of claim 17, wherein the HMGCR protein fragment comprises amino acids 340-888 of the HMGCR protein.

Details for Patent 9,506,924

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. RITUXAN rituximab Injection 103705 11/26/1997 ⤷  Try a Trial 2030-04-16
Idec Pharmaceuticals Corp. RITUXAN rituximab Injection 103737 02/19/2002 ⤷  Try a Trial 2030-04-16
Genentech, Inc. RITUXAN HYCELA rituximab and hyaluronidase human Injection 761064 06/22/2017 ⤷  Try a Trial 2030-04-16
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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