Claims for Patent: 9,452,219

Summary for Patent: 9,452,219

Title:	Anti-nucleolin agent-conjugated nanoparticles
Abstract:	A composition comprises an anti-nucleolin agent conjugated to nanoparticles. The nanoparticles are non-magnetic, not iron oxide and not polyacrylamide. Furthermore, a pharmaceutical composition for treating cancer comprises a composition including an anti-nucleolin agent conjugated to nanoparticles, and a pharmaceutically acceptable carrier.
Inventor(s):	Bates; Paula J. (Louisville, KY), Malik; Mohammad Tariq (Prospect, KY), Kang; Kyung A. (Louisville, KY)
Assignee:	University of Louisville Research Foundation, Inc. (Louisville, KY)
Application Number:	14/122,617
Patent Claims:	1. A composition, comprising an anti-nucleolin agent conjugated to nanoparticles, wherein the nanoparticles comprise gold and wherein the anti-nucleolin agent is AS1411 (SEQ ID NO: 10). 2. The composition of claim 1, further comprising a cyanine dye. 3. The composition of claim 1, wherein the nanoparticles have an average diameter of 1 to 50 nm. 4. The composition of claim 1, wherein the nanoparticles have an average diameter of 1 to 20 nm. 5. A pharmaceutical composition, comprising the composition of claim 1 and a pharmaceutically acceptable carrier. 6. A method of treating cancer, comprising administering an effective amount of the pharmaceutical composition of claim 5, to a patient in need thereof. 7. The method of claim 6, wherein the cancer is selected from the group consisting of melanoma, lymphoma, plasmocytoma, sarcoma, glioma, thymoma, leukemia, breast cancer, prostate cancer, colon cancer, liver cancer, esophageal cancer, brain cancer, lung cancer, ovary cancer, endometrial cancer, bladder cancer, kidney cancer, cervical cancer and hepatoma. 8. The method of claim 7, wherein the cancer is selected from the group consisting of breast cancer, prostate cancer, colon cancer and lung cancer. 9. The method of claim 6, further comprising administering a second cancer treatment selected from the group consisting of vinorelbine, mytomycin, camptothecin, cyclyphosphamide, methotrexate, tamoxifen citrate, 5-fluorouracil, irinotecan, doxorubicin, flutamide, paclitaxel, docetaxel, vinblastine, imatinib mesylate, anthracycline, letrozole, arsenic trioxide, anastrozole, triptorelin pamoate, ozogamicin, irinotecan hydrochloride, BCG live, leuprolide acetate implant, bexarotene, exemestane, topotecan hydrochloride, gemcitabine HCL, daunorubicin hydrochloride, toremifene citrate, carboplatin, cisplatin, oxaliplatin and any other platinum-containing oncology drug, trastuzumab, lapatinib, gefitinb, cetuximab, panitumumab, temsirolimus, everolimus, vandetanib, vemurafenib, crizotinib, vorinostat, bevacizumab, radiation therapy, hyperthermia, gene therapy and photodynamic therapy. 10. A pharmaceutical composition, comprising the composition of claim 2 and a pharmaceutically acceptable carrier. 11. A pharmaceutical composition, comprising the composition of claim 3 and a pharmaceutically acceptable carrier. 12. A pharmaceutical composition, comprising the composition of claim 4 and a pharmaceutically acceptable carrier. 13. A method of treating cancer, comprising administering an effective amount of the pharmaceutical composition of claim 10, to a patient in need thereof. 14. A method of treating cancer, comprising administering an effective amount of the pharmaceutical composition of claim 11, to a patient in need thereof. 15. A method of treating cancer, comprising administering an effective amount of the pharmaceutical composition of claim 12, to a patient in need thereof. 16. The method of claim 15, wherein the cancer is selected from the group consisting of melanoma, lymphoma, plasmocytoma, sarcoma, glioma, thymoma, leukemia, breast cancer, prostate cancer, colon cancer, liver cancer, esophageal cancer, brain cancer, lung cancer, ovary cancer, endometrial cancer, bladder cancer, kidney cancer, cervical cancer and hepatoma. 17. The method of claim 16, wherein the cancer is selected from the group consisting of breast cancer, prostate cancer, colon cancer and lung cancer. 18. The method of claim 15, further comprising administering a second cancer treatment selected from the group consisting of vinorelbine, mytomycin, camptothecin, cyclyphosphamide, methotrexate, tamoxifen citrate, 5-fluorouracil, irinotecan, doxorubicin, flutamide, paclitaxel, docetaxel, vinblastine, imatinib mesylate, anthracycline, letrozole, arsenic trioxide, anastrozole, triptorelin pamoate, ozogamicin, irinotecan hydrochloride, BCG live, leuprolide acetate implant, bexarotene, exemestane, topotecan hydrochloride, gemcitabine HCL, daunorubicin hydrochloride, toremifene citrate, carboplatin, cisplatin, oxaliplatin and any other platinum-containing oncology drug, trastuzumab, lapatinib, gefitinb, cetuximab, panitumumab, temsirolimus, everolimus, vandetanib, vemurafenib, crizotinib, vorinostat, bevacizumab, radiation therapy, hyperthermia, gene therapy and photodynamic therapy. 19. The method of claim 14, wherein the cancer is selected from the group consisting of breast cancer, prostate cancer, colon cancer and lung cancer. 20. The method of claim 14, further comprising administering a second cancer treatment selected from the group consisting of vinorelbine, mytomycin, camptothecin, cyclyphosphamide, methotrexate, tamoxifen citrate, 5-fluorouracil, irinotecan, doxorubicin, flutamide, paclitaxel, docetaxel, vinblastine, imatinib mesylate, anthracycline, letrozole, arsenic trioxide, anastrozole, triptorelin pamoate, ozogamicin, irinotecan hydrochloride, BCG live, leuprolide acetate implant, bexarotene, exemestane, topotecan hydrochloride, gemcitabine HCL, daunorubicin hydrochloride, toremifene citrate, carboplatin, cisplatin, oxaliplatin and any other platinum-containing oncology drug, trastuzumab, lapatinib, gefitinb, cetuximab, panitumumab, temsirolimus, everolimus, vandetanib, vemurafenib, crizotinib, vorinostat, bevacizumab, radiation therapy, hyperthermia, gene therapy and photodynamic therapy.

Details for Patent 9,452,219

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Teknika Llc	TICE BCG	bcg live	For Injection	102821	06/21/1989		2039-02-26
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	09/25/1998		2039-02-26
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	02/10/2017		2039-02-26
Eli Lilly And Company	ERBITUX	cetuximab	Injection	125084	02/12/2004		2039-02-26
Eli Lilly And Company	ERBITUX	cetuximab	Injection	125084	03/28/2007		2039-02-26
Genentech, Inc.	AVASTIN	bevacizumab	Injection	125085	02/26/2004		2039-02-26