Claims for Patent: 9,446,079

Summary for Patent: 9,446,079

Title:	Honey and silver nitrate composition, composition dressing and methods of making same
Abstract:	A composition of medical grade honey and silver nitrate is described for treatment of burns, ulcers, and open wounds. The disclosed composition is a gel of medical grade honey and silver nitrate in a ratio of about 211 to 1, with a moisture level of no greater than 20 percent and wherein the medical grade honey contains about 300 kg/mg of methylglyoxal. Also described are methods of making and using the honey and silver nitrate mixture for treatment of burns, ulcers and wounds including direct application to a treatment area as well as impregnating a gauze fabric with a composition of medical grade honey and silver nitrate for application to a treatment area.
Inventor(s):	Buckley; Thomas L. (Laguna Niguel, CA), Thain; Andrew (Staffordshire, GB)
Assignee:	Links Medical Products, Incorporated (Irvine, CA)
Application Number:	14/824,134
Patent Claims:	1. A composition for treating burns, ulcers and wounds, comprising: a mixture of sterilized honey and a dissolved silver ion salt in a preferred sterilized honey to silver ion salt ratio of between 200 to 1 and 250 to 1, wherein the sterilized honey has a moisture content of between one and twenty percent; and wherein the sterilized honey contains a preferred amount of methylglyoxal of between 83 milligrams of methylglyoxal per 1.0 kilogram of sterilized honey and 1000 milligrams of methylglyoxal per 1.0 kilogram of sterilized honey. 2. The composition, according to claim 1, wherein a more preferred sterilized honey to silver salt ion ratio is 211 to 1; and a more preferred amount of methylglyoxal is between 300 milligrams of methylglyoxal per 1.0 kilogram of sterilized honey and 350 milligrams of methylglyoxal per 1.0 kilogram of sterilized honey. 3. The composition, according to claim 1, wherein the dissolved silver ion salt is a dissolved silver nitrate salt. 4. The composition, according to claim 2, wherein the dissolved silver ion salt is a dissolved silver nitrate salt. 5. The composition, according to claim 3, wherein the mixture of sterilized honey and dissolved silver nitrate salt is a gel. 6. The composition, according to claim 1, wherein the sterilized honey is selected from a group consisting of: Manuka, Pasture, Ling Kahami, Portobello, Greek Pine, Yorkshire, Chilean Ulmo, Chilean Rain Forrest, Australian Eucalyptus, Himalayan, Scottish Heather, Scottish Wild Flower, English Heather, English Wildflower, New Zealand Clover, Australian Clover, Cuban Comparitan, Acacia, Spanish Blossom, Tasmanian Leatherwood, Organic Honey All, New Zealand Beach, Kanuka, New Zealand Bush, New Zealand Honey Dew, Jarrah, Thyme, Kamahi and Leptospermum honeys of all varieties. 7. A method of preparing a sterilized honey and silver nitrate composition for treating wounds, comprising the steps of: heating an amount of sterilized honey, wherein the sterilized honey contains a preferred amount of methylglyoxal of between 83 milligrams of methylglyoxal per 1.0 kilograms of sterilized honey and 1000 milligrams of methylglyoxal per 1.0 kilogram of sterilized honey; mixing an amount of sterile water with an amount of silver nitrate to dissolve the amount of silver nitrate in the sterile water; blending the mixture of dissolved silver nitrate and sterile water with the amount of heated sterilized honey while maintaining, a honey moisture content of between one and twenty percent; placing the blended sterilized honey and the silver nitrate into a high speed mixer; and mixing the blended sterilized honey and the silver nitrate in the mixer until a fully homogenized composition of sterilized honey and silver nitrate is achieved. 8. The method of preparing a sterilized honey and silver nitrate composition, according to claim 7, wherein the step of blending includes: maintaining a preferred ratio of sterilized honey and silver nitrate of between 200 to 1 and 250 to 1. 9. The method of preparing a sterilized honey and silver nitrate composition, according to claim 8, wherein a more preferred sterilized honey to silver nitrate ratio is 211 to 1; and wherein a more preferred amount of methylglyoxal is between 300 milligrams of methylglyoxal per 1.0 kilogram of sterilized honey and 350 milligrams of methylglyoxal per 1.0 kilogram of sterilized honey. 10. The method of preparing a sterilized honey and silver nitrate composition, according to claim 9, wherein the step of heating includes: heating the amount of sterilized honey to about 30.degree. C. 11. The method of preparing a sterilized honey and silver nitrate composition, according to claim 7, wherein the step of heating includes: heating the amount of sterilized honey to about 30.degree. C. 12. The method of preparing a sterilized honey and silver nitrate composition, according to claim 7, wherein the sterilized honey is selected from a group consisting of: Manuka, Pasture, Ling Kahami, Portobello, Greek Pine, Yorkshire, Chilean Ulmo, Chilean Rain Forrest, Australian Eucalyptus, Himalayan, Scottish Heather, Scottish Wild Flower, English Heather, English Wildflower, New Zealand Clover, Australian Clover, Cuban Comparitan, Acacia, Spanish Blossom, Tasmanian Leatherwood, Organic Honey All, New Zealand Beach, Kanuka, New Zealand Bush, New Zealand Honey Dew, Jarrah, Thyme, Kamahi and Leptospermum honeys of all varieties. 13. A composition for treating burns, ulcers and wounds, comprising: a volume of sterilized honey containing a preferred amount of methylglyoxal of between 83 milligrams of methylglyoxal per 1.0 kilogram of sterilized honey and 1000 milligrams of methylglyoxal per 1.0 kilogram of sterilized honey; a volume of dissolved silver nitrate in a sufficient volume to provide a mixture of sterilized honey and silver nitrate in a ratio of between 200 to 1 to 250 to 1 and; wherein the sterilized honey has a moisture content of between one and twenty percent to facilitate inhibiting the growth of mold, mildew, fungus and yeast. 14. The composition for treating burns, ulcers and wounds, according to claim 13, wherein a more preferred sterilized honey to silver nitrate ratio is 211 to 1; and a more preferred amount of methylglyoxal is between 300 milligrams of methylglyoxal per 1.0 kilogram of sterilized honey and 350 milligrams of methylglyoxal per 1.0 kilogram of sterilized honey. 15. The composition for treating burns, ulcers and wounds, according to claim 13, wherein the sterilized honey is selected from a group consisting of: Manuka, Pasture, Ling Kahami, Portobello, Greek Pine, Yorkshire, Chilean Ulmo, Chilean Rain Forrest, Australian Eucalyptus, Himalayan, Scottish Heather, Scottish Wild Flower, English Heather, English Wildflower, New Zealand Clover, Australian Clover, Cuban Comparitan, Acacia, Spanish Blossom, Tasmanian Leatherwood, Organic Honey All, New Zealand Beach, Kanuka, New Zealand Bush, New Zealand Honey Dew, Jarrah, Thyme, Kamahi and Leptospermum honeys of all varieties. 16. The composition for treating burns, ulcers and wounds, according to claim 13, wherein the mixture of sterilized honey and silver nitrate is a gel.

Details for Patent 9,446,079

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	ZOSTAVAX	zoster vaccine live	For Injection	125123	05/25/2006		2039-09-22