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Last Updated: April 19, 2024

Claims for Patent: 9,446,038

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Summary for Patent: 9,446,038

Title:	Method and composition for treating a serotonin receptor-mediated condition
Abstract:	A method and composition for treating serotonin receptor-mediated conditions.
Inventor(s):	Polymeropoulos; Mihael H. (Potomac, MD), Baroldi; Paolo (Potomac, MD), Wolfgang; Curt (Germantown, MD)
Assignee:	Vanda Pharmaceuticals, Inc. (Washington, DC)
Application Number:	14/088,877
Patent Claims:	1. A method comprising: internally administering to an animal suffering from platelet aggregation an effective amount of 4-[3-[4-(6-fluoro-1,2,-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methox- y-benzoic acid or pharmaceutically-acceptable salt thereof, thereby treating platelet aggregation in the animal. 2. The method of claim 1, wherein internally administering the effective amount of 4-[3-[4-(6-fluoro-1,2,-benzisoxazol-3-yl)-1-piperidinyl]propoxy- ]-3-methoxy-benzoic acid or pharmaceutically-acceptable salt thereof antagonizes a 5-HT.sub.2A receptor not located in the brain. 3. The method of claim 1, further comprising: administering to the animal at least one antithrombotic agent. 4. The method of claim 3, wherein the antithrombotic agent is selected from a group consisting of: clopidogrel bisulfate, streptokinase, alteplase, aprotinin, aspirin, and warfarin. 5. The method of claim 1, wherein the 4-[3-[4-(6-fluoro-1,2,-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methox- y-benzoic acid or pharmaceutically-acceptable salt thereof is in a controlled release pharmaceutical dosage form. 6. The method of claim 1, wherein the 4-[3-[4-(6-fluoro-1,2,-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methox- y-benzoic acid or pharmaceutically-acceptable salt thereof administered to the animal is between about 1 mg/day and about 500 mg/day. 7. The method of claim 6, wherein the amount is between about 5 mg/day and about 100 mg/day. 8. The method of claim 1, wherein the amount of 4-[3-[4-(6-fluoro-1,2,-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methox- y-benzoic acid or pharmaceutically-acceptable salt thereof administered to the animal is between about 0.01 mg/kg/day and about 10 mg/kg/day. 9. The method of claim 8, wherein the amount is between about 0.5 mg/kg/day and about 1.5 mg/kg/day. 10. The method of claim 1, wherein the animal is a human.

Details for Patent 9,446,038

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Bayer Healthcare Pharmaceuticals Inc.	TRASYLOL	aprotinin	Injection	020304	12/29/1993	⤷ Try a Trial	2039-02-26
Genentech, Inc.	ACTIVASE	alteplase	For Injection	103172	11/13/1987	⤷ Try a Trial	2039-02-26
Genentech, Inc.	CATHFLO ACTIVASE	alteplase	For Injection	103172	09/04/2001	⤷ Try a Trial	2039-02-26
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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