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Last Updated: March 28, 2024

Claims for Patent: 9,434,947


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Summary for Patent: 9,434,947
Title:Modulation of KCNH2 isoform expression by oligonucleotides as a therapeutic approach for long QT syndrome
Abstract: Oligonucleotides with activity in preventing poly(A) adenylation at intron 9 of the KCNH2 gene, as well as pharmaceutical compositions comprising the oligonucleotides and methods of using the oligonucleotides to treat long QT syndrome in a subject are disclosed. The oligonucleotides include antisense sequences corresponding to sites termed DSE-1 and DSE-2 in intron 9.
Inventor(s): Zhou; Zhengfeng (Portland, OR), Gong; Qiuming (Portland, OR), Stump; Matthew (Portland, OR)
Assignee: OREGON HEALTH & SCIENCE UNIVERSITY (Portland, OR)
Application Number:14/600,958
Patent Claims:1. An isolated oligonucleotide comprising SEQ ID NO: 4 that inhibits the formation of a poly(A) signal in intron 9 of KCNH2, wherein the oligonucleotide is no more than 30 nucleotides in length and wherein the oligonucleotide comprises a modified nucleotide, a locked nucleotide, a G-clamp nucleotide, a nucleotide base analog, a 3'-terminal cap moiety, or a phosphate backbone modification.

2. The oligonucleotide of claim 1 comprising SEQ ID NO: 5.

3. The oligonucleotide of claim 2 consisting of a sequence of SEQ ID NO: 5.

4. The oligonucleotide of claim 1 comprising a morpholino nucleotide.

5. The oligonucleotide of claim 4 wherein all of the nucleic acids in the oligonucleotide are morpholino nucleotides.

6. A pharmaceutical composition comprising an effective amount of the oligonucleotide of claim 1 and a pharmaceutically acceptable carrier.

7. A method of treating long-QT syndrome caused by mutations in the KCNH2 gene, the method comprising: administering to the subject the pharmaceutical composition of claim 6, thereby treating the long-QT syndrome.

Details for Patent 9,434,947

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 ⤷  Try a Trial 2039-02-26
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try a Trial 2039-02-26
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 ⤷  Try a Trial 2039-02-26
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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