Claims for Patent: 9,408,916

Summary for Patent: 9,408,916

Title:	Polymer films
Abstract:	Biodegradable, cross-linked polymer films and methods of making the same are described. The polymer films can be used for preventing adhesions following surgery and/or delivering therapeutic agents.
Inventor(s):	Cruise; Gregory M. (Rancho Santa Margaria, CA), Hincapie; Gloria (Tustin, CA), Harris; Clayton (Tustin, CA), Wu; Yue (Tustin, CA)
Assignee:	MicroVention, Inc. (Tustin, CA)
Application Number:	14/491,813
Patent Claims:	1. A polymer film comprising: at least one monomer including at least one functional group; and at least one crosslinker selected from bis-glycidyl amino alcohol, bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate, ##STR00029## ##STR00030## wherein a, b, c, d, e, and f are each independently 1-20; wherein the polymer film has a thickness between about 40 .mu.m and about 1,200 .mu.m and is biodegradable. 2. The polymer film of claim 1, wherein the polymer film has a shape selected from a circle, square, rectangle, triangle, ellipse, or pentagon. 3. The polymer film of claim 1, wherein the at least one functional group is acrylate, acrylamide, methacrylate, or methacrylamide. 4. The polymer film of claim 1, wherein the at least one monomer includes an ionizable functional group. 5. The polymer film of claim 4, wherein the ionizable functional group is basic. 6. The polymer film of claim 4, wherein the ionizable functional group is acidic. 7. The polymer film of claim 1, wherein the at least one crosslinker includes at least two functional groups. 8. The polymer film of claim 1, wherein the crosslinker includes at least one linkage susceptible to degradation through hydrolysis or enzymatic action. 9. The polymer film of claim 8, wherein the at least one linkage is an ester, a thioester, a carbonate, a carbamate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenase, a peptide cleavable by matrix elastase, a peptide cleavable by matrix cathepsin, or a combination thereof. 10. The polymer film of claim 9, including a second crosslinker including a second linkage selected from an ester, a thioester, a carbonate, a carbamate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, and a peptide cleavable by matrix cathepsins. 11. The polymer film of claim 1, wherein the polymer film is substantially degraded within about 6 months of implantation. 12. The polymer film of claim 1, wherein the polymer film is substantially degraded within about 1 month of implantation. 13. The polymer film of claim 1, wherein the at least one monomer is acrylamide and the at least one crosslinker is bis-glycidyl amino alcohol. 14. The polymer film of claim 1, wherein the at least one monomer is acrylamide and the at least one crosslinker is bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate. 15. A method of making a polymer film comprising: reacting a prepolymer solution including at least one monomer including at least one functional group, at least one crosslinker susceptible to degradation, and an initiator; and forming the polymer film, wherein the polymer film has a thickness between about 40 .mu.m and about 1,200 .mu.m, wherein the at least one crosslinker is selected from bis-glycidyl amino alcohol, bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate, ##STR00031## ##STR00032## wherein a, b, c, d, e, and f are each independently 1-20. 16. The method of claim 15, wherein the film is formed between two plates including at least one spacer. 17. The method of claim 15, wherein the initiator is N,N,N',N'-tetramethylethylenediamine. 18. The method of claim 15, wherein the polymer film has a shape selected from a circle, square, rectangle, triangle, ellipse, or pentagon. 19. The method of claim 15, wherein the at least one functional group is acrylate, acrylamide, methacrylate, or methacrylamide. 20. The method of claim 15, wherein the polymer film is biodegradable. 21. The method of claim 20, wherein the polymer film is substantially degraded within about 1 month of implantation. 22. The method of claim 20, wherein the at least one monomer is acrylamide and the at least one crosslinker is bis-glycidyl amino alcohol. 23. The method of claim 20, wherein the at least one monomer is acrylamide and the at least one crosslinker is bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate.

Details for Patent 9,408,916

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2033-09-19