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Last Updated: April 25, 2024

Claims for Patent: 9,351,961

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Summary for Patent: 9,351,961

Title:	Method of treating multiple sclerosis
Abstract:	The invention provides methods for treating multiple sclerosis by administering biotin. The invention also provides methods for treating sequelae after multiple sclerosis attacks by administering biotin.
Inventor(s):	Sedel; Frederic (Paris, FR)
Assignee:	Assistance Publique Hopitaux De Paris (Paris, FR)
Application Number:	14/458,625
Patent Claims:	1. A method of treating a patient suffering from multiple sclerosis, comprising administering biotin to a patient in need thereof, wherein said multiple sclerosis is a progressive form of multiple sclerosis, wherein treatment with biotin has a duration of at least 3 months, and to said patient at a dose of at least 1 mg/kg/day. 2. The method of claim 1, wherein said biotin is in a form suitable for oral administration. 3. The method of claim 1, wherein said biotin is in the form of a composition containing biotin and excipients, without any other active ingredient. 4. The method of claim 1, wherein said biotin is in the form of an injectable composition. 5. A method of treating sequelae attributable to multiple sclerosis attacks in a patient, comprising administering biotin to a patient in need thereof, wherein treatment with biotin has a duration of at least 3 months, and to said patient at a dose of at least 1 mg/kg/day. 6. The method of claim 5, wherein said biotin is in a form suitable for oral administration. 7. The method of claim 5, wherein said biotin is in the form of a composition containing biotin and excipients, without any other active ingredient. 8. The method of claim 5, wherein said biotin is in the form of an injectable composition. 9. The method of claim 1, wherein the biotin is administered with one or more of interferon beta, glatiramer acetate, natalizumab, fingolimod, fampridine and mitoxantrone. 10. The method of claim 5, wherein the biotin is administered with one or more of interferon beta, glatiramer acetate, natalizumab, fingolimod, fampridine and mitoxantrone. 11. The method of claim 1, wherein the biotin is administered in combination with fampridine. 12. The method of claim 1, wherein the biotin administered is between 100 and 500 mg/day. 13. The method of claim 1, wherein the biotin administered is at least 300 mg/day. 14. The method of claim 5, wherein the biotin is administered in combination with fampridine. 15. The method of claim 5, wherein the biotin administered is between 100 and 500 mg/day. 16. The method of claim 5, wherein the biotin administered is at least 300 mg/day. 17. The method of claim 1, wherein the biotin administered is at least 100 mg/day. 18. The method of claim 5, wherein the biotin administered is at least 100 mg/day.

Details for Patent 9,351,961

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Biogen Inc.	TYSABRI	natalizumab	Injection	125104	11/23/2004	⤷ Try a Trial	2032-07-26
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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