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Last Updated: March 28, 2024

Claims for Patent: 9,346,862


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Summary for Patent: 9,346,862
Title:Canine babesiosis vaccine antigen
Abstract: The present invention relates to the field of veterinary parasitology, especially of canine Babesiosis. In particular the invention relates to a polypeptide being a novel canine Babesia antigen (CBA), or fragments thereof, and to compositions comprising this antigen, to nucleic acids encoding the antigen, antibodies against the antigen, and medical uses of this antigen, fragments, antibodies, or encoding nucleic acids. In particular the invention relates to the use of such components in vaccines against canine Babesiosis.
Inventor(s): Schetters; Theodorus Petrus Maria (Cujik, NL), Moubri-Menage; Karina (Mauguio, FR), Kleuskens; Jos (Gennep, NL), Rohwer; Andreas Walter Claudius (Worms, DE)
Assignee: Intervet Inc. (Madison, NJ)
Application Number:14/557,833
Patent Claims:1. An isolated nucleic acid comprising a nucleotide sequence encoding a polypeptide or an immunogenic fragment thereof that is at least 8 amino acids in length; wherein said polypeptide comprises an amino acid sequence having a sequence identity selected from the group consisting of greater than 76% with the amino acid sequence of SEQ ID NO: 1, greater than 68% with the amino acid sequence of SEQ ID NO: 3, or greater than 76% with the amino acid sequence of SEQ ID NO: 1 and greater than 68% with the amino acid sequence of SEQ ID NO: 3; wherein said polypeptide and said immunogenic fragment thereof individually induce an immune response against a canine Babesia parasite; wherein said nucleotide sequence is under the control of a functionally linked heterologous promoter and does not comprise an intron.

2. The isolated nucleic acid of claim 1, wherein the polypeptide comprises an amino acid sequence comprising the amino acid sequence of SEQ ID NO: 1.

3. The isolated nucleic acid of claim 1, wherein the polypeptide comprises an amino acid sequence comprising the amino acid sequence of SEQ ID NO: 3.

4. A vaccine for canines against Babesiosis, comprising the nucleic acid of claim 1, and a pharmaceutically acceptable carrier.

5. A diagnostic test kit comprising the nucleic acid of claim 1.

6. A method for the preparation of a vaccine for canines against Babesiosis, said method comprising expressing the nucleic acid of claim 1 in a recombinant expression system admixing the resulting expressed product with a pharmaceutically acceptable carrier.

Details for Patent 9,346,862

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 ⤷  Try a Trial 2030-12-29
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try a Trial 2030-12-29
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 ⤷  Try a Trial 2030-12-29
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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