Claims for Patent: 9,322,066
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Summary for Patent: 9,322,066
Title: | Predictors for cancer treatment |
Abstract: | The present invention provides methods of predicting a response to a cancer treatment by determining CD68 level or PSMB1 (P11A) polymorphism in a biological sample and the presence or quantity of a second biomarker in the patient. The invention also provides kits and methods for treating cancer. |
Inventor(s): | Ricci; Deborah (Ringoes, NJ), Li; Weimin (Radnor, PA), Henitz; Erin DeVay (Flemington, NJ) |
Assignee: | Janssen Pharmaceutica NV (Beerse, BE) |
Application Number: | 13/569,517 |
Patent Claims: | 1. A method for predicting response to a cancer treatment comprising bortezomib and rituximab in a non-Hodgkin's lymphoma cancer patient, comprising: detecting the
presence of a first predictor in a biological sample from said non-Hodgkin's lymphoma cancer patient, wherein said first predictor is low CD68; detecting the presence of a second predictor in said non-Hodgkin's lymphoma cancer patient, wherein said
second predictor is a PSMB1 (P11A) polymorphism comprising a C/G heterozygote; wherein the presence of a biomarker pair comprising the low CD68 and the PSMB1 (P11A) polymorphism is correlated with at least one positive outcome; and selecting the
non-Hodgkin's lymphoma cancer patients that have an increased chance for a favorable outcome to the cancer treatment comprising bortezomib and rituximab based on the presence of the biomarker pair comprising the first and second predictor; and treating
the selected non-Hodgkin's lymphoma cancer patients with the cancer treatment comprising bortezomib and rituximab.
2. The method of claim 1, wherein low CD68 is 50% or less CD68-positive cells, as determined by immunohistochemistry. 3. The method of claim 1, wherein the non-Hodgkin lymphoma is follicular B-cell non-Hodgkin lymphoma. |
Details for Patent 9,322,066
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Genentech, Inc. | RITUXAN | rituximab | Injection | 103705 | 11/26/1997 | ⤷ Try a Trial | 2031-08-11 |
Idec Pharmaceuticals Corp. | RITUXAN | rituximab | Injection | 103737 | 02/19/2002 | ⤷ Try a Trial | 2031-08-11 |
Genentech, Inc. | RITUXAN HYCELA | rituximab and hyaluronidase human | Injection | 761064 | 06/22/2017 | ⤷ Try a Trial | 2031-08-11 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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